Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting

KALYONCU, MUKADDES; Kısaoğlu, Hakan; Baba, Ozge

doi:10.55730/1300-0144.5572

Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting

Özge ÖZİŞ BABA, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Romatoloji Anabilim Dalı, Trabzon, Türkiye)

Hakan KISAOĞLU, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Romatoloji Anabilim Dalı, Trabzon, Türkiye)

Mukaddes KALYONCU (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Romatoloji Anabilim Dalı, Trabzon, Türkiye)

Turkish Journal of Medical Sciences

14 5

Yıl: 2023 Cilt: 53 Sayı: 1 Sayfa Aralığı: 193 - 198 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5572 İndeks Tarihi: 24-03-2023

Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting

Öz:

Background/aim: Antinuclear antibody (ANA) is among the most frequently ordered tests in paediatric rheumatology setting. Diseases like systemic lupus erythematosus and Sjögren syndrome is closely related with a positive ANA and classified as ANA associated diseases. Besides, ANA test is ordered in patients with juvenile idiopathic arthritis (JIA) to assess the risk for uveitis and a positive ANA could be detected in children with nonrheumaticrheumatic conditions. In this study, we aimed to investigate frequency of positive ANA in paediatric rheumatology setting and the association of immunofluorescence staining patterns and titres of ANA with rheumatic diseases. Materials and methods: Immunofluorescence staining patterns, and titres of the ANA and diagnoses of children who tested for ANA between January 2016 and December 2021 were retrospectively analysed. Results: Among 2477 patients with ANA tested, 28.1% had a positive ANA result. Among them, 39.2% had a diagnosis of a rheumatic disease. Most common rheumatic diagnosis was JIA (43.8%) and ANA associated diseases were observed in 24.5% of the patients with a rheumatic diagnosis. While ANA associated diseases had significantly more frequent homogenous staining, dense fine speckled pattern was significantly more common in children with nonrheumatic diagnoses. Despite ANA associated diseases was found to be significantly associated with higher titres, no difference was observed between patients with JIA and nonrheumatic conditions. Conclusion: Our study showed that the majority of children with a positive ANA test were not diagnosed with a rheumatic disease. While titres and patterns of ANA were found to be important in diagnosis of rheumatic diseases, ordering ANA test with solid indications might give improved probability of rheumatic diagnoses in children with a positive test.

Anahtar Kelime: Antinuclear antibody ANA associated diseases dense fine speckled pattern immunofluorescence staining pattern titre

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Baba O, Kısaoğlu H, KALYONCU M (2023). Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting. , 193 - 198. 10.55730/1300-0144.5572
Chicago	Baba Ozge,Kısaoğlu Hakan,KALYONCU MUKADDES Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting. (2023): 193 - 198. 10.55730/1300-0144.5572
MLA	Baba Ozge,Kısaoğlu Hakan,KALYONCU MUKADDES Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting. , 2023, ss.193 - 198. 10.55730/1300-0144.5572
AMA	Baba O,Kısaoğlu H,KALYONCU M Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting. . 2023; 193 - 198. 10.55730/1300-0144.5572
Vancouver	Baba O,Kısaoğlu H,KALYONCU M Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting. . 2023; 193 - 198. 10.55730/1300-0144.5572
IEEE	Baba O,Kısaoğlu H,KALYONCU M "Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting." , ss.193 - 198, 2023. 10.55730/1300-0144.5572
ISNAD	Baba, Ozge vd. "Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting". (2023), 193-198. https://doi.org/10.55730/1300-0144.5572

APA	Baba O, Kısaoğlu H, KALYONCU M (2023). Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting. Turkish Journal of Medical Sciences, 53(1), 193 - 198. 10.55730/1300-0144.5572
Chicago	Baba Ozge,Kısaoğlu Hakan,KALYONCU MUKADDES Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting. Turkish Journal of Medical Sciences 53, no.1 (2023): 193 - 198. 10.55730/1300-0144.5572
MLA	Baba Ozge,Kısaoğlu Hakan,KALYONCU MUKADDES Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting. Turkish Journal of Medical Sciences, vol.53, no.1, 2023, ss.193 - 198. 10.55730/1300-0144.5572
AMA	Baba O,Kısaoğlu H,KALYONCU M Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting. Turkish Journal of Medical Sciences. 2023; 53(1): 193 - 198. 10.55730/1300-0144.5572
Vancouver	Baba O,Kısaoğlu H,KALYONCU M Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting. Turkish Journal of Medical Sciences. 2023; 53(1): 193 - 198. 10.55730/1300-0144.5572
IEEE	Baba O,Kısaoğlu H,KALYONCU M "Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting." Turkish Journal of Medical Sciences, 53, ss.193 - 198, 2023. 10.55730/1300-0144.5572
ISNAD	Baba, Ozge vd. "Significance of the immunofluorescence staining patterns and titres of the antinuclear antibody test in paediatric rheumatology setting". Turkish Journal of Medical Sciences 53/1 (2023), 193-198. https://doi.org/10.55730/1300-0144.5572