High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis
Yıl: 2022 Cilt: 12 Sayı: 4 Sayfa Aralığı: 672 - 679 Metin Dili: İngilizce DOI: 10.31832/smj.1128434 İndeks Tarihi: 27-03-2023
High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis
Öz: Introduction: Metastasectomy is one of the effective treatment methods for liver metastases developing from primary colorectal cancer (CRC). However, recurrence after metastasectomy is the biggest problem in these cancers. The present study aimed to examine the role of Epithelial-Mesenchymal Transition (EMT) in the development of recurrence after metastasectomy in liver metastases from primary CRCs. Materials and Methods: In the study, 85 patients were evaluated. RNA was isolated from archive tumors and normal tissues of the patients. Expression profiles of 7 different EMT markers were examined using qRT-PCR. Results: Metastasis to the liver developed in 24.7% (n=21) of 85 CRC. Recurrence was observed in 42.3% (n=9) of liver metastases after metastasectomy. Statistically significant increases were detected in the expression of EMT markers TWIST and SNAIL in the development of mCC in primary CRC (p
Anahtar Kelime: Yüksek Snail ekspresyonu Kolorektal Kanser Kökenli Karaciğer Metaztaslarında Rezeksiyon Sonrası Nüksü Yansıtır
Öz: Amaç: Cerrahi tedavi, primer kolorektal kanserden (KRK) gelişen karaciğer metastazları için etkili tedavi yöntemlerinden biridir. Bununla birlikte metastazektomi sonrası nüks bu kanserlerdeki en büyük problemdir. Mevcut çalışmada, primer KRK’lardan gelişen karaciğer metastazlarında Epitelyal-Mezenkimal Tranzisyon (EMT)’nin metastazektomi sonrası nüks gelişimindeki rolünün incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmada, 85 hasta, 12 normal kolon, 8 normal karaciğer dokusu değerlendirildi. Hastalara ait arşiv materyali tümör ve normal dokularından RNA izolasyonları yapıldı. qRT-PCR kullanılarak 7 farklı EMT belirtecinin ekspresyon profili incelendi. Bulgular: Seksen beş KRK’nın %24.7 (n=21)’sinde karaciğere metastazı gelişti. Karaciğer metastazı belirlenen hastaların %42.3’ünde (n=9) metastazektomi sonrası nüks gözlendi. Primer KRK’dan mKK gelişiminde EMT belirteçlerinden TWIST ve SNAIL ekspresyonlarında istatistiksel olarak anlamlı artış belirlendi (p
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KARAMUSTAFAOĞLU A, Aksoy S, Tunca B, Ercelik m, Tekin C, Ugras N, Yerci Ö, Aksoy F, Kaya E (2022). High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis. , 672 - 679. 10.31832/smj.1128434 |
| Chicago | KARAMUSTAFAOĞLU AHMET,Aksoy Seçil,Tunca Berrin,Ercelik melis,Tekin Cagla,Ugras Nesrin,Yerci Ömer,Aksoy Fuat,Kaya Ekrem High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis. (2022): 672 - 679. 10.31832/smj.1128434 |
| MLA | KARAMUSTAFAOĞLU AHMET,Aksoy Seçil,Tunca Berrin,Ercelik melis,Tekin Cagla,Ugras Nesrin,Yerci Ömer,Aksoy Fuat,Kaya Ekrem High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis. , 2022, ss.672 - 679. 10.31832/smj.1128434 |
| AMA | KARAMUSTAFAOĞLU A,Aksoy S,Tunca B,Ercelik m,Tekin C,Ugras N,Yerci Ö,Aksoy F,Kaya E High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis. . 2022; 672 - 679. 10.31832/smj.1128434 |
| Vancouver | KARAMUSTAFAOĞLU A,Aksoy S,Tunca B,Ercelik m,Tekin C,Ugras N,Yerci Ö,Aksoy F,Kaya E High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis. . 2022; 672 - 679. 10.31832/smj.1128434 |
| IEEE | KARAMUSTAFAOĞLU A,Aksoy S,Tunca B,Ercelik m,Tekin C,Ugras N,Yerci Ö,Aksoy F,Kaya E "High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis." , ss.672 - 679, 2022. 10.31832/smj.1128434 |
| ISNAD | KARAMUSTAFAOĞLU, AHMET vd. "High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis". (2022), 672-679. https://doi.org/10.31832/smj.1128434 |
| APA | KARAMUSTAFAOĞLU A, Aksoy S, Tunca B, Ercelik m, Tekin C, Ugras N, Yerci Ö, Aksoy F, Kaya E (2022). High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis. Sakarya Tıp Dergisi, 12(4), 672 - 679. 10.31832/smj.1128434 |
| Chicago | KARAMUSTAFAOĞLU AHMET,Aksoy Seçil,Tunca Berrin,Ercelik melis,Tekin Cagla,Ugras Nesrin,Yerci Ömer,Aksoy Fuat,Kaya Ekrem High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis. Sakarya Tıp Dergisi 12, no.4 (2022): 672 - 679. 10.31832/smj.1128434 |
| MLA | KARAMUSTAFAOĞLU AHMET,Aksoy Seçil,Tunca Berrin,Ercelik melis,Tekin Cagla,Ugras Nesrin,Yerci Ömer,Aksoy Fuat,Kaya Ekrem High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis. Sakarya Tıp Dergisi, vol.12, no.4, 2022, ss.672 - 679. 10.31832/smj.1128434 |
| AMA | KARAMUSTAFAOĞLU A,Aksoy S,Tunca B,Ercelik m,Tekin C,Ugras N,Yerci Ö,Aksoy F,Kaya E High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis. Sakarya Tıp Dergisi. 2022; 12(4): 672 - 679. 10.31832/smj.1128434 |
| Vancouver | KARAMUSTAFAOĞLU A,Aksoy S,Tunca B,Ercelik m,Tekin C,Ugras N,Yerci Ö,Aksoy F,Kaya E High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis. Sakarya Tıp Dergisi. 2022; 12(4): 672 - 679. 10.31832/smj.1128434 |
| IEEE | KARAMUSTAFAOĞLU A,Aksoy S,Tunca B,Ercelik m,Tekin C,Ugras N,Yerci Ö,Aksoy F,Kaya E "High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis." Sakarya Tıp Dergisi, 12, ss.672 - 679, 2022. 10.31832/smj.1128434 |
| ISNAD | KARAMUSTAFAOĞLU, AHMET vd. "High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis". Sakarya Tıp Dergisi 12/4 (2022), 672-679. https://doi.org/10.31832/smj.1128434 |
