TY  - JOUR
TI  - High SNAIL Expression Reflects Of Recurrence After Resection Colorectal Cancer Liver Metastasis
AB  - Introduction: Metastasectomy is one of the effective treatment methods for liver metastases developing from primary colorectal cancer (CRC). However, recurrence after metastasectomy is the biggest problem in these cancers.  The present study aimed to examine the role of Epithelial-Mesenchymal Transition (EMT) in the development of recurrence after metastasectomy in liver metastases from primary CRCs. Materials and Methods: In the study, 85 patients were evaluated. RNA was isolated from archive tumors and normal tissues of the patients. Expression profiles of 7 different EMT markers were examined using qRT-PCR. Results: Metastasis to the liver developed in 24.7% (n=21) of 85 CRC. Recurrence was observed in 42.3% (n=9) of liver metastases after metastasectomy. Statistically significant increases were detected in the expression of EMT markers TWIST and SNAIL in the development of mCC in primary CRC (p
AU  - KARAMUSTAFAOĞLU, AHMET
AU  - Tunca, Berrin
AU  - Ercelik, melis
AU  - Tekin, Cagla
AU  - Ugras, Nesrin
AU  - Yerci, Ömer
AU  - Aksoy, Fuat
AU  - Kaya, Ekrem
AU  - Aksoy, Seçil
DO  - 10.31832/smj.1128434
PY  - 2022
JO  - Sakarya Tıp Dergisi
VL  - 12
IS  - 4
SN  - 2146-409X
SP  - 672
EP  - 679
DB  - TRDizin
UR  - http://search/yayin/detay/1160568
ER  -