The impact of antiphospholipid antibodies in Takayasu arteritis

Background/aim: The significance of antiphospholipid antibodies (aPL) is controversial in Takayasu arteritis (TA). This study was conducted to explore the frequency of aPL and their association with disease-related complications in TA. Materials and methods: This cross-sectional study was conducted to investigate the presence of anti-cardiolipin (aCL), anti-beta 2 glycoprotein- 1(aβ2G1) antibodies, and lupus anticoagulant (LA) in TA patients. TA patients admitted to the Department of Rheumatology of Hacettepe University Faculty of Medicine between December 2015 and September 2016 who fulfilled the American College of Rheumatology (ACR) classification criteria for TA were consecutively enrolled in the study. Patients were grouped according to aPL positivity and compared in terms of disease manifestations, type of vascular involvement at diagnosis, and vascular complications/interventions attributable to TA. Results: Fifty-three TA (49 female) patients were enrolled in the study. We detected 9 (16.9%) patients with IgM and/or IgG aβ2G1 and/or LA positivity. There were no patients with positive aCL. All aβ2G1 titers were low. There were no differences in terms of symptoms, signs, type of vascular involvement, the number of patients with disease-related complications or vascular interventions/surgery between aPL (+) and aPL(-) groups (p > 0.05 for all). The number of patients with thrombotic lesions was similar between the groups (p > 0.05). There were no patients with a history of venous thrombosis or on anticoagulant treatment in the aPL(+) group. Only 1 patient with IgM aβ2G1 (+) had a history of pregnancy loss. Conclusion: Our results indicate that aPL positivity is not rare in TA. On the other hand, all aPL titers were low and no differences were found in the frequency of disease-related complications between aPL(+) and aPL(-) patient groups. Only TA patients with atypical manifestations with high suspicion of aPL-related complications should be considered to be investigated for aPL.

Anahtar Kelime: Takayasu arteritis anti-beta 2 glycoprotein-1 antibodies anti-cardiolipin antibody lupus anticoagulant antiphospholipid antibody syndrome

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	fırat şentürk e, erden a, Sari A, Armagan B, Kılıç L, Kalyoncu U, Karadag O, Apras Bilgen S, KİRAZ S, Ertenli I, akdogan a (2023). The impact of antiphospholipid antibodies in Takayasu arteritis. , 199 - 205. 10.55730/1300-0144.5573
Chicago	fırat şentürk esra,erden abdulsamet,Sari Alper,Armagan Berkan,Kılıç Levent,Kalyoncu Umut,Karadag Omer,Apras Bilgen Sule,KİRAZ SEDAT,Ertenli Ihsan,akdogan ali The impact of antiphospholipid antibodies in Takayasu arteritis. (2023): 199 - 205. 10.55730/1300-0144.5573
MLA	fırat şentürk esra,erden abdulsamet,Sari Alper,Armagan Berkan,Kılıç Levent,Kalyoncu Umut,Karadag Omer,Apras Bilgen Sule,KİRAZ SEDAT,Ertenli Ihsan,akdogan ali The impact of antiphospholipid antibodies in Takayasu arteritis. , 2023, ss.199 - 205. 10.55730/1300-0144.5573
AMA	fırat şentürk e,erden a,Sari A,Armagan B,Kılıç L,Kalyoncu U,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,akdogan a The impact of antiphospholipid antibodies in Takayasu arteritis. . 2023; 199 - 205. 10.55730/1300-0144.5573
Vancouver	fırat şentürk e,erden a,Sari A,Armagan B,Kılıç L,Kalyoncu U,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,akdogan a The impact of antiphospholipid antibodies in Takayasu arteritis. . 2023; 199 - 205. 10.55730/1300-0144.5573
IEEE	fırat şentürk e,erden a,Sari A,Armagan B,Kılıç L,Kalyoncu U,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,akdogan a "The impact of antiphospholipid antibodies in Takayasu arteritis." , ss.199 - 205, 2023. 10.55730/1300-0144.5573
ISNAD	fırat şentürk, esra vd. "The impact of antiphospholipid antibodies in Takayasu arteritis". (2023), 199-205. https://doi.org/10.55730/1300-0144.5573

APA	fırat şentürk e, erden a, Sari A, Armagan B, Kılıç L, Kalyoncu U, Karadag O, Apras Bilgen S, KİRAZ S, Ertenli I, akdogan a (2023). The impact of antiphospholipid antibodies in Takayasu arteritis. Turkish Journal of Medical Sciences, 53(1), 199 - 205. 10.55730/1300-0144.5573
Chicago	fırat şentürk esra,erden abdulsamet,Sari Alper,Armagan Berkan,Kılıç Levent,Kalyoncu Umut,Karadag Omer,Apras Bilgen Sule,KİRAZ SEDAT,Ertenli Ihsan,akdogan ali The impact of antiphospholipid antibodies in Takayasu arteritis. Turkish Journal of Medical Sciences 53, no.1 (2023): 199 - 205. 10.55730/1300-0144.5573
MLA	fırat şentürk esra,erden abdulsamet,Sari Alper,Armagan Berkan,Kılıç Levent,Kalyoncu Umut,Karadag Omer,Apras Bilgen Sule,KİRAZ SEDAT,Ertenli Ihsan,akdogan ali The impact of antiphospholipid antibodies in Takayasu arteritis. Turkish Journal of Medical Sciences, vol.53, no.1, 2023, ss.199 - 205. 10.55730/1300-0144.5573
AMA	fırat şentürk e,erden a,Sari A,Armagan B,Kılıç L,Kalyoncu U,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,akdogan a The impact of antiphospholipid antibodies in Takayasu arteritis. Turkish Journal of Medical Sciences. 2023; 53(1): 199 - 205. 10.55730/1300-0144.5573
Vancouver	fırat şentürk e,erden a,Sari A,Armagan B,Kılıç L,Kalyoncu U,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,akdogan a The impact of antiphospholipid antibodies in Takayasu arteritis. Turkish Journal of Medical Sciences. 2023; 53(1): 199 - 205. 10.55730/1300-0144.5573
IEEE	fırat şentürk e,erden a,Sari A,Armagan B,Kılıç L,Kalyoncu U,Karadag O,Apras Bilgen S,KİRAZ S,Ertenli I,akdogan a "The impact of antiphospholipid antibodies in Takayasu arteritis." Turkish Journal of Medical Sciences, 53, ss.199 - 205, 2023. 10.55730/1300-0144.5573
ISNAD	fırat şentürk, esra vd. "The impact of antiphospholipid antibodies in Takayasu arteritis". Turkish Journal of Medical Sciences 53/1 (2023), 199-205. https://doi.org/10.55730/1300-0144.5573