Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results

Mehmet SEVİM, (Kütahya Sağlık Bilimleri Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Kütahya, Türkiye)
Sibel Canbaz KABAYA, (Kütahya Sağlık Bilimleri Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Kütahya,)
Bekir ARAS, (Kütahya Sağlık Bilimleri Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Kütahya, Türkiye)
Şahin KABAY (Altınbaş Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)
Grand journal of urology (Online)
8 1
Yıl: 2023 Cilt: 3 Sayı: 1 Sayfa Aralığı: 19 - 25 Metin Dili: İngilizce DOI: 10.5505/GJU.2023.73644 İndeks Tarihi: 05-04-2023

Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results

Öz:
Objective: In this study, it was aimed to determine the effectiveness of percutaneous tibial nerve stimulation (PTNS) treatment in neurogenic overactive bladder (NOAB) due to multiple sclerosis (MS) by extending the application interval for 24 months from the beginning. Materials and Methods: Patients completed the PTNS treatment with tapering protocols applied for 6, 9, 12, and 24 months. After 12 weeks of therapy, PTNS was applied at 14 day intervals for 3, at 21 day intervals for 3, and at 28 day intervals for 3 months. The patients completed a 3-day voiding diary at the 3rd, 6th, 9th, 12th, and 24th months. The patients were requested to complete validated questionnaires (ICIQ-SF, OAB-V8, OAB-q SF) within 3-month intervals thereafter during their enrolment in the study. Results: The mean age of 57 patients who completed the PTNS treatment protocol and were included in the study was 42.6 ± 8.2 (23-64) years. Fifteen (26.3%) patients were male and 42 (73.6%) were female. The improvements for all voiding diary parameters were significant at 3rd, 6th, 9th, 12th, and 24th months when compared with the baseline. After 24 months, the daily frequencies of voiding decreased by 6.7 (p<0.001), urge urinary incontinence by 4.2 (p<0.001), urge by 8.4 (p<0.001), nocturia by 2.2 (p<0.001), and the mean voiding volume increased by 85.8 cc (p<0.001). No treatment-related side effects were reported in the patients for 24 months. Conclusion: This study showed that the symptoms of the patients with NOAB due to MS improved after 24 months of PTNS treatment.
Anahtar Kelime: multiple sclerosis percutaneous tibial nerve stimulation neurogenic overactive bladder detrusor overactivity posterior tibial nerve

Multiple Skleroza Bağlı Gelişen Nörojenik Aşırı Aktif Mesane Tedavisinde Kullanılan Perkütan Tibial Sinir Stimülasyonunun 24 Aylık Uzun Dönem Sonuçları

Öz:
Amaç: Bu çalışmada multiple skleroz (MS)’a bağlı gelişen nörojenik aşırı aktif mesanede (NAAM) perkütan tibial sinir stimulasyonu (PTNS) tedavisinin başlangıçtan itibaren 24 ay boyunca uygulama süre aralığının uzatılarak etkinliğinin belirlenmesi amaçlanmıştır. Gereçler ve Yöntemler: PTNS tedavisinde 24 aylık tedavi protokolü başlangıçta 12 hafta süresince her hafta, sonraki 3 ay boyunca 14 günde bir, devam eden 3 ay boyunca 21 günde bir uygulandıktan sonra 24 aya kadar 28 günde bir olacak şekilde uygulandı. Hastalar 3 günlük işeme günlüğü ile gündüz işeme sıklığı, sıkışma, sıkışma tipi idrar kaçırma, noktüri, işeme hacimlerini belirlemek için başlangıçta ve daha sonra 3, 6, 9, 12 ve 24’üncü aylarda değerlendirildiler. Ayrıca hastalar başlangıçta ve 3 aylık aralıklarla valide edilmiş anketler (ICIQ-SF, OAB-V8, OAB-q SF) ile değerlendirildiler. Bulgular: PTNS tedavi protokolünü tamamlayan ve çalışmaya dahil edilen 57 hastanın yaş ortalaması 42.6 ± 8.2 (23-64) idi. Çalışmadaki hastaların 15’i (%26,3) erkek, 42’si (%73,6) kadındı. İşeme günlüğü parametrelerindeki başlangıç, 6, 9, 12 ve 24’üncü aylardaki iyileşmeler anlamlı olarak gözlendi. Başlangıç değerine göre 6, 9, 12 ve 24’üncü aylardaki ICIQ-SF, OAB-V8 ve OAB-q’da gösterilen semptom şiddetinde ve sağlıkla ilişkili yaşam kalitesinde istatistiksel olarak anlamlı iyileşmeler görüldü. 24 ay sonunda işeme sıklığı günlük 6.7 (p<0.001), sıkışma tipi idrar kaçırma 4.2 (p<0.001), sıkışma 8.4 (p<0.001), noktüri günlük 2.2 (p<0.001) azalmış ve işeme hacmi ortalama 85.8 cc (p<0.001) artmıştır. Hastalarda 24 ay boyunca tedaviye bağlı yan etki bildirilmemiştir. Sonuç: Bu çalışma, MS hastalığına bağlı gelişen NAAM’ye sahip hastalarda, 24 aylık PTSS tedavileriyle semptomlarında iyileşme gözlendiğini göstermiştir.
Anahtar Kelime: multiple skleroz perkütan tibial sinir stimülasyonu nörojenik aşırı aktif mesane detrüsör aşırı aktivitesi posterior tibial sinir

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA sevim m, canbaz kabay s, Aras B, KABAY S (2023). Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results. , 19 - 25. 10.5505/GJU.2023.73644
Chicago sevim mehmet,canbaz kabay sibel,Aras Bekir,KABAY SAHIN Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results. (2023): 19 - 25. 10.5505/GJU.2023.73644
MLA sevim mehmet,canbaz kabay sibel,Aras Bekir,KABAY SAHIN Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results. , 2023, ss.19 - 25. 10.5505/GJU.2023.73644
AMA sevim m,canbaz kabay s,Aras B,KABAY S Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results. . 2023; 19 - 25. 10.5505/GJU.2023.73644
Vancouver sevim m,canbaz kabay s,Aras B,KABAY S Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results. . 2023; 19 - 25. 10.5505/GJU.2023.73644
IEEE sevim m,canbaz kabay s,Aras B,KABAY S "Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results." , ss.19 - 25, 2023. 10.5505/GJU.2023.73644
ISNAD sevim, mehmet vd. "Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results". (2023), 19-25. https://doi.org/10.5505/GJU.2023.73644
APA sevim m, canbaz kabay s, Aras B, KABAY S (2023). Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results. Grand journal of urology (Online), 3(1), 19 - 25. 10.5505/GJU.2023.73644
Chicago sevim mehmet,canbaz kabay sibel,Aras Bekir,KABAY SAHIN Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results. Grand journal of urology (Online) 3, no.1 (2023): 19 - 25. 10.5505/GJU.2023.73644
MLA sevim mehmet,canbaz kabay sibel,Aras Bekir,KABAY SAHIN Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results. Grand journal of urology (Online), vol.3, no.1, 2023, ss.19 - 25. 10.5505/GJU.2023.73644
AMA sevim m,canbaz kabay s,Aras B,KABAY S Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results. Grand journal of urology (Online). 2023; 3(1): 19 - 25. 10.5505/GJU.2023.73644
Vancouver sevim m,canbaz kabay s,Aras B,KABAY S Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results. Grand journal of urology (Online). 2023; 3(1): 19 - 25. 10.5505/GJU.2023.73644
IEEE sevim m,canbaz kabay s,Aras B,KABAY S "Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results." Grand journal of urology (Online), 3, ss.19 - 25, 2023. 10.5505/GJU.2023.73644
ISNAD sevim, mehmet vd. "Long-Term Effects of Percutaneous Tibial Nerve Stimulation Treatment for Neurogenic Overactive Bladder Due to Multiple Sclerosis: 24-Month Results". Grand journal of urology (Online) 3/1 (2023), 19-25. https://doi.org/10.5505/GJU.2023.73644
Sayfa Oluşturulma Tarihi
24-04-2024 6:17

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