Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey

ÖZKURT, Zübeyde Nur; DÜNDAR, Nazlıhan BOYACI; Turkoglu, Melda; Aygencel, Gulbin; GÖKÇE, Onur; HAŞİMOĞLU, Merve; yegin, zeynep arzu; YAĞCI, Münci

doi:10.55730/1300-0144.5590

Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey

Gülbin AYGENCEL, (Gazi Üniversitesi, Tıp Fakültesi, Yoğun Bakım Anabilim Dalı, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Onur GÖKÇE, (Gazi Üniversitesi, Tıp Fakültesi, Yoğun Bakım Anabilim Dalı, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Merve HAŞİMOĞLU, (Gazi Üniversitesi, Tıp Fakültesi, Yoğun Bakım Anabilim Dalı, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Nazlıhan BOYACI DÜNDAR, (Gazi Üniversitesi, Tıp Fakültesi, Yoğun Bakım Anabilim Dalı, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Melda TÜRKOĞLU, (Gazi Üniversitesi, Tıp Fakültesi, Yoğun Bakım Anabilim Dalı, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Zeynep Arzu YEĞİN, (Gazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Anabilim Dalı, Ankara, Türkiye)

Zübeyde Nur ÖZKURT, (Gazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Anabilim Dalı, Ankara, Türkiye)

Münci YAĞCI (Gazi Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Medical Sciences

17 10

Yıl: 2023 Cilt: 53 Sayı: 1 Sayfa Aralığı: 340 - 351 Metin Dili: Türkçe DOI: 10.55730/1300-0144.5590 İndeks Tarihi: 29-03-2023

Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey

Öz:

Background/aim: Patients with hematological malignancies (HM) often require admission to the intensive care unit (ICU) due to organ failure, disease progression or treatment-related complications, and they generally have a poor prognosis. Therefore, understanding the factors affecting ICU mortality in HM patients is important. In this study, we aimed to identify the risk factors for ICU mortality in our critically ill HM patients. Materials and methods: We retrospectively reviewed the medical records of HM patients who were hospitalized in our medical ICU between January 1, 2010 and December 31, 2018. We recorded some parameters of these patients and compared these parameters by statistically between survivors and nonsurvivors to determine the risk factors for ICU mortality. Results: The study included 368 critically ill HM patients who were admitted to our medical ICU during a 9-year period. The median age was 58 (49–67) years and 63.3% of the patients were male. Most of the patients (43.2%) had acute leukemia. Hematopoietic stem cell transplantation (HSCT) was performed in 153 (41.6%) patients. The ICU mortality rate was 51.4%. According to univariable analyses, a lot of parameters (e.g., admission APACHE II and SOFA scores, length of ICU stay, some laboratory parameters at the ICU admission, the reason for ICU admission, comorbidities, type of HM, type of HSCT, infections on ICU admission and during ICU stay, etc.) were significantly different between survivors and nonsurvivors. However, only high SOFA scores at ICU admission (OR:1.281, p = 0.004), presence of septic shock (OR:17.123, p = 0.0001), acute kidney injury (OR:48.284, p = 0.0001), and requirement of invasive mechanical ventilation support during ICU stay (OR:23.118, p = 0.0001) were independent risk factors for ICU mortality. Conclusion: In our cohort, critically ill HM patients had high ICU mortality. We found four independent predictors for ICU mortality. Yet, there is still a need for further research to better understand poor outcome predictors in critically ill HM patients.

Anahtar Kelime: Outcome prognostic factors hematological malignancy patients intensive care unit acute renal failure invasive mechanical ventilation septic shock SOFA score

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Aygencel G, GÖKÇE O, HAŞİMOĞLU M, DÜNDAR N, Turkoglu M, yegin z, ÖZKURT Z, YAĞCI M (2023). Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey. , 340 - 351. 10.55730/1300-0144.5590
Chicago	Aygencel Gulbin,GÖKÇE Onur,HAŞİMOĞLU Merve,DÜNDAR Nazlıhan BOYACI,Turkoglu Melda,yegin zeynep arzu,ÖZKURT Zübeyde Nur,YAĞCI Münci Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey. (2023): 340 - 351. 10.55730/1300-0144.5590
MLA	Aygencel Gulbin,GÖKÇE Onur,HAŞİMOĞLU Merve,DÜNDAR Nazlıhan BOYACI,Turkoglu Melda,yegin zeynep arzu,ÖZKURT Zübeyde Nur,YAĞCI Münci Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey. , 2023, ss.340 - 351. 10.55730/1300-0144.5590
AMA	Aygencel G,GÖKÇE O,HAŞİMOĞLU M,DÜNDAR N,Turkoglu M,yegin z,ÖZKURT Z,YAĞCI M Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey. . 2023; 340 - 351. 10.55730/1300-0144.5590
Vancouver	Aygencel G,GÖKÇE O,HAŞİMOĞLU M,DÜNDAR N,Turkoglu M,yegin z,ÖZKURT Z,YAĞCI M Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey. . 2023; 340 - 351. 10.55730/1300-0144.5590
IEEE	Aygencel G,GÖKÇE O,HAŞİMOĞLU M,DÜNDAR N,Turkoglu M,yegin z,ÖZKURT Z,YAĞCI M "Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey." , ss.340 - 351, 2023. 10.55730/1300-0144.5590
ISNAD	Aygencel, Gulbin vd. "Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey". (2023), 340-351. https://doi.org/10.55730/1300-0144.5590

APA	Aygencel G, GÖKÇE O, HAŞİMOĞLU M, DÜNDAR N, Turkoglu M, yegin z, ÖZKURT Z, YAĞCI M (2023). Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey. Turkish Journal of Medical Sciences, 53(1), 340 - 351. 10.55730/1300-0144.5590
Chicago	Aygencel Gulbin,GÖKÇE Onur,HAŞİMOĞLU Merve,DÜNDAR Nazlıhan BOYACI,Turkoglu Melda,yegin zeynep arzu,ÖZKURT Zübeyde Nur,YAĞCI Münci Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey. Turkish Journal of Medical Sciences 53, no.1 (2023): 340 - 351. 10.55730/1300-0144.5590
MLA	Aygencel Gulbin,GÖKÇE Onur,HAŞİMOĞLU Merve,DÜNDAR Nazlıhan BOYACI,Turkoglu Melda,yegin zeynep arzu,ÖZKURT Zübeyde Nur,YAĞCI Münci Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey. Turkish Journal of Medical Sciences, vol.53, no.1, 2023, ss.340 - 351. 10.55730/1300-0144.5590
AMA	Aygencel G,GÖKÇE O,HAŞİMOĞLU M,DÜNDAR N,Turkoglu M,yegin z,ÖZKURT Z,YAĞCI M Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey. Turkish Journal of Medical Sciences. 2023; 53(1): 340 - 351. 10.55730/1300-0144.5590
Vancouver	Aygencel G,GÖKÇE O,HAŞİMOĞLU M,DÜNDAR N,Turkoglu M,yegin z,ÖZKURT Z,YAĞCI M Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey. Turkish Journal of Medical Sciences. 2023; 53(1): 340 - 351. 10.55730/1300-0144.5590
IEEE	Aygencel G,GÖKÇE O,HAŞİMOĞLU M,DÜNDAR N,Turkoglu M,yegin z,ÖZKURT Z,YAĞCI M "Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey." Turkish Journal of Medical Sciences, 53, ss.340 - 351, 2023. 10.55730/1300-0144.5590
ISNAD	Aygencel, Gulbin vd. "Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey". Turkish Journal of Medical Sciences 53/1 (2023), 340-351. https://doi.org/10.55730/1300-0144.5590