TY  - JOUR
TI  - Risk factors for ICU mortality in patients with hematological malignancies: a single- center, retrospective cohort study from Turkey
AB  - Background/aim: Patients with hematological malignancies (HM) often require admission to the intensive care unit (ICU) due to organ failure, disease progression or treatment-related complications, and they generally have a poor prognosis. Therefore, understanding the factors affecting ICU mortality in HM patients is important. In this study, we aimed to identify the risk factors for ICU mortality in our critically ill HM patients. Materials and methods: We retrospectively reviewed the medical records of HM patients who were hospitalized in our medical ICU between January 1, 2010 and December 31, 2018. We recorded some parameters of these patients and compared these parameters by statistically between survivors and nonsurvivors to determine the risk factors for ICU mortality. Results: The study included 368 critically ill HM patients who were admitted to our medical ICU during a 9-year period. The median age was 58 (49–67) years and 63.3% of the patients were male. Most of the patients (43.2%) had acute leukemia. Hematopoietic stem cell transplantation (HSCT) was performed in 153 (41.6%) patients. The ICU mortality rate was 51.4%. According to univariable analyses, a lot of parameters (e.g., admission APACHE II and SOFA scores, length of ICU stay, some laboratory parameters at the ICU admission, the reason for ICU admission, comorbidities, type of HM, type of HSCT, infections on ICU admission and during ICU stay, etc.) were significantly different between survivors and nonsurvivors. However, only high SOFA scores at ICU admission (OR:1.281, p = 0.004), presence of septic shock (OR:17.123, p = 0.0001), acute kidney injury (OR:48.284, p = 0.0001), and requirement of invasive mechanical ventilation support during ICU stay (OR:23.118, p = 0.0001) were independent risk factors for ICU mortality. Conclusion: In our cohort, critically ill HM patients had high ICU mortality. We found four independent predictors for ICU mortality. Yet, there is still a need for further research to better understand poor outcome predictors in critically ill HM patients.
AU  - ÖZKURT, Zübeyde Nur
AU  - DÜNDAR, Nazlıhan BOYACI
AU  - Turkoglu, Melda
AU  - Aygencel, Gulbin
AU  - GÖKÇE, Onur
AU  - HAŞİMOĞLU, Merve
AU  - yegin, zeynep arzu
AU  - YAĞCI, Münci
DO  - 10.55730/1300-0144.5590
PY  - 2023
JO  - Turkish Journal of Medical Sciences
VL  - 53
IS  - 1
SN  - 1300-0144
SP  - 340
EP  - 351
DB  - TRDizin
UR  - http://search/yayin/detay/1161061
ER  -