PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE
Yıl: 2023 Cilt: 6 Sayı: 1 Sayfa Aralığı: 49 - 54 Metin Dili: İngilizce DOI: 10.53446/actamednicomedia.1164931 İndeks Tarihi: 16-06-2023
PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE
Öz: Objective: Progress in therapy of childhood non-Hodgkin lymphoma (NHL) is one of the stunning success stories of the past two decades. In developed countries, more than 80% of children with NHL can now be cured with modern therapy, even patients with widely disseminated disease. The aim of this study is to analyze all NHL patients who were treated in a single tertiary center in Turkiye. Methods: An analysis of data of children with NHL, diagnosed and treated between 2003 and 2012 according to the original BerlinFrankfurt-Munster (BFM) protocol in Kocaeli University Pediatric Oncology Department was carried out. Results: Forty-seven children were eligible for analysis. Mean age at diagnosis was 9.6 years with a male: female ratio of 1.9. Thirtyone patients (66%) were mature B-cell NHL with 23 patients (48.9%) Burkitt lymphoma, 7 patients (14.8%) diffuse large B-cell lymphoma, one patient (%2) primary mediastinal large B-cell lymphoma; 13 patients (27.6%) were lymphoblastic lymphoma with 11 patients (23.3%) T-lymphoblastic lymphoma and 2 patients (4.2%) B-lymphoblastic lymphoma, and also 3 patients (6.3%) were mature-T cell lymphoma-anaplastic large cell lymphoma. Four-year event-free survival was 78.7% and overall survival was 80.8%. Conclusion: These results with BFM protocol management reflect good treatment outcomes in our patients.
Anahtar Kelime: PEDİATRİK NON-HODGKİN LENFOMA: TÜRKİYE'DE ÜÇÜNCÜ BASAMAK MERKEZİ'NDEN BERLİN-FRANKFURT-MUNSTER (BFM) PROTOKOLLERİ İLE ON YILLIK DENEYİM
Öz: Amaç: Çocukluk çağı Non-Hodgkin lenfoma (NHL) tedavisindeki ilerleme, son yirmi yılın çarpıcı başarı öykülerinden biridir. Gelişmiş ülkelerde, NHL'li çocukların %80'inden fazlası, yaygın hastalık durumunda bile modern terapi ile tedavi edilebilmektedir. Bu çalışmanın amacı, Türkiye'de tek bir üçüncü basamak merkezde tedavi edilen tüm NHL hastalarını analiz etmektir. Yöntem: Kocaeli Üniversitesi Pediatrik Onkoloji Anabilim Dalı'nda 2003-2012 yılları arasında orijinal Berlin-Frankfurt-Munster (BFM) protokolüne göre teşhis ve tedavi edilen NHL'li çocukların verilerinin analizi yapıldı. Bulgular: Kırk yedi çocuk analiz için uygun bulundu. Ortalama tanı yaşı 9,6, erkek/kız oranı 1,9 idi. 31 hasta (%66) matür B hücreli NHL, bunların 23’ü (%48.9) Burkitt lenfoma, 7’si (%14.8) diffüz büyük B hücreli lenfoma, biri (%2) primer mediastinal büyük B hücreli lenfoma idi; 13 hasta (%27,6) lenfoblastik lenfoma, bunların 11’i (%23,3) T-lenfoblastik lenfoma ve 2’si (%4,2) B- lenfoblastik lenfoma ve ayrıca 3 hasta (%6,3) matür T hücreli lenfoma-anaplastik büyük hücreli lenfoma idi. Dört yıllık olaysız sağkalım %78,7 ve genel sağkalım %80,8 idi. Sonuç: BFM protokolü uygulamasıyla elde edilen bu sonuçlar, hastalarımızda iyi tedavi sonuçlarını yansıtmaktadır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | karadoğan M, Demirsoy U, ANIK Y, Aksu G, corapcioglu f (2023). PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE. , 49 - 54. 10.53446/actamednicomedia.1164931 |
| Chicago | karadoğan Meriban,Demirsoy Ugur,ANIK YONCA,Aksu Gorkem,corapcioglu funda PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE. (2023): 49 - 54. 10.53446/actamednicomedia.1164931 |
| MLA | karadoğan Meriban,Demirsoy Ugur,ANIK YONCA,Aksu Gorkem,corapcioglu funda PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE. , 2023, ss.49 - 54. 10.53446/actamednicomedia.1164931 |
| AMA | karadoğan M,Demirsoy U,ANIK Y,Aksu G,corapcioglu f PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE. . 2023; 49 - 54. 10.53446/actamednicomedia.1164931 |
| Vancouver | karadoğan M,Demirsoy U,ANIK Y,Aksu G,corapcioglu f PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE. . 2023; 49 - 54. 10.53446/actamednicomedia.1164931 |
| IEEE | karadoğan M,Demirsoy U,ANIK Y,Aksu G,corapcioglu f "PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE." , ss.49 - 54, 2023. 10.53446/actamednicomedia.1164931 |
| ISNAD | karadoğan, Meriban vd. "PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE". (2023), 49-54. https://doi.org/10.53446/actamednicomedia.1164931 |
| APA | karadoğan M, Demirsoy U, ANIK Y, Aksu G, corapcioglu f (2023). PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE. Acta Medica Nicomedia, 6(1), 49 - 54. 10.53446/actamednicomedia.1164931 |
| Chicago | karadoğan Meriban,Demirsoy Ugur,ANIK YONCA,Aksu Gorkem,corapcioglu funda PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE. Acta Medica Nicomedia 6, no.1 (2023): 49 - 54. 10.53446/actamednicomedia.1164931 |
| MLA | karadoğan Meriban,Demirsoy Ugur,ANIK YONCA,Aksu Gorkem,corapcioglu funda PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE. Acta Medica Nicomedia, vol.6, no.1, 2023, ss.49 - 54. 10.53446/actamednicomedia.1164931 |
| AMA | karadoğan M,Demirsoy U,ANIK Y,Aksu G,corapcioglu f PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE. Acta Medica Nicomedia. 2023; 6(1): 49 - 54. 10.53446/actamednicomedia.1164931 |
| Vancouver | karadoğan M,Demirsoy U,ANIK Y,Aksu G,corapcioglu f PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE. Acta Medica Nicomedia. 2023; 6(1): 49 - 54. 10.53446/actamednicomedia.1164931 |
| IEEE | karadoğan M,Demirsoy U,ANIK Y,Aksu G,corapcioglu f "PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE." Acta Medica Nicomedia, 6, ss.49 - 54, 2023. 10.53446/actamednicomedia.1164931 |
| ISNAD | karadoğan, Meriban vd. "PEDIATRIC NON-HODGKIN LYMPHOMA: TEN-YEAR EXPERIENCE WITH BERLIN-FRANKFURT-MUNSTER (BFM) PROTOCOLS FROM A TERTIARY CARE HOSPITAL IN TURKIYE". Acta Medica Nicomedia 6/1 (2023), 49-54. https://doi.org/10.53446/actamednicomedia.1164931 |
