Yıl: 2023 Cilt: 30 Sayı: 2 Sayfa Aralığı: 248 - 251 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2022.11.335 İndeks Tarihi: 05-04-2023

Heart rate recovery in patients with inflammatory bowel disease in clinical remission

Öz:
Aim: The purpose of this report was to assess Heart Rate Recovery (HRR) which is known to be a predictor of cardiovascular diseases in patients diagnosed with Inflammatory Bowel Disease (IBD). Materials and Methods: Fifty-two patients (41 patients with Ulcerative Colitis (UC) and 11 patients with Crohn’s Disease (CD)) in remission and 50 healthy volunteers were enrolled in the study. All participants was performed treadmill exercise testing. HRR was expressed as the decrease in the heart rate from peak exercise value to 1 min and 2 min after the exercise. The HRR index was calculated for the first (HRR1) and the second (HRR2) minutes of the recovery phase. Results: The maximal and baseline heart rate during exercise stress test were the same in control groups ,UC and CD (156.6±13.3 vs. 153.8±12.7 vs 152.7±13.6, p=0.432; 93.18±16.37, 94.05±14.8 vs. 86.5±13.9, p=0.313, respectively). Also, there was no difference between the groups in means of the first and the second minute HRR in- dices (HRR1: 30.7±11.8, 34.5±8.8, 33.9±13.5, p=0.403; HRR2: 51.4±15.4, 54.1±14.6, 55.1±16.9, p=0.807). Conclusion: Many systemic inflammatory diseases are thought to be related to an in- creased risk of cardiovascular diseases. This association has not been well determined in patients with IBD. We found that the HRR index was not different between the CD and UC patients in remission in this report. Further studies may be needed in this way, and all IBD patients should be suspected of the presence of cardiovascular risk factors to reduce mortality and morbidity.
Anahtar Kelime: Inflammatory bowel disease Ulcerative colitis Crohn’s disease Heart rate recovery Remission

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Lichtenstein GR, Goldman L, Schafer AI. Inflammatory Bowel Disease. Goldman’s Cecil Medicine 2015; 1 (24): 913-4.
  • 2. Maule S, Pierangeli G, Cevoli S, et al. Sympathetic hyperactivity in patients with ulcerative colitis. Clin Auton Res 2007; 17: 217- 20. doi: 10.1007/s10286-007-0425-0.
  • 3. Goyal RK, Hirano I. The enteric nervous system. N england J Med 1996; 334, 1106-15. doi: 10.1056/NEJM199604253341707.
  • 4. Tougas G. The autonomic nervous system in functional bowel disorders, Can J Gastroenterol 1996; 13, 15-7. doi: 10.1155/1999/707105.
  • 5. McCafferty DM, Wallace JL, Sharkey KA. Effects of chemi- cal sympathectomy and sensory nerve ablation on experimen- tal colitis in the rat, Am J Physiol 1997; 272: 272-80. doi: 10.1152/ajpgi.1997.272.2.G272.
  • 6. Furlan R, Ardizzone S, Palazzolo L, et al. Sympathetic over- activity in active ulcerative colitis: effects of clonidine, Am J Physiol Regul Integr Comp Physiol 2006; 290, 224-32. doi: 10.1152/ajpregu.00442.2005.
  • 7. Eliakim R, Karmeli F, Rachmilewitz, et al. Effect of chronic nico- tine administration on trinitrobenzene sulphonic acid induced colitis, Eur J Gastroenterol Hepatol 1998; 10, 1013.
  • 8. Bernik TR, Friedman SG, Ochani M, et al. Pharmacological stimulation of the cholinergic antiinflammatory pathway, J Exp Med 2002; 195, 781-8. doi: 10.1084/jem.20011714.
  • 9. Bigeh A, Sanchez A, Maestas C, Gulati M. Inflammatory bowel disease and the risk for cardiovascular disease: Does all inflam- mation lead to heart disease? Trends Cardiovasc Med. 2020 Nov; 30(8): 463-9. doi: 10.1016/j.tcm.2019.10.001.
  • 10. Filimon AM, Negreanu L, Doca M, et al. Cardiovascular involvement in inflammatory bowel disease: Dangerous li- aisons, World J Gastroenterol 2015; 21 (33), 9688-92. doi: 10.3748/wjg.v21.i33.9688.
  • 11. Arai Y, Saul JP, Albrecht P, et al. Modulation of car- diac autonomic activity during and immediately after exer- cise. Am J Physiol 1989; 256: 132-41. doi: 10.1152/ajp- heart.1989.256.1.H132.
  • 12. Imai K, Sato H, Hori M, et al. Vagally mediated heart rate re- covery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. J Am Coll Cardiol 1994;24: 1529-35. doi: 10.1016/0735-1097(94)90150-3.
  • 13. Schwartz PJ, La Rovere MT, Vanoli E. Autonomic nervous sys- tem and sudden cardiac death: experimental basis and clini- cal observations for post-myocardial infarction risk stratification. Circulation 1992; 85:Suppl I:I-77.
  • 14. Cole CR, Blackstone EH, Pashkow FJ, et al. Heart-rate re- covery immediately after exercise as a predictor of mor- tality. N Engl J Med. 1999 Oct 28; 341(18):1351-7. doi: 10.1056/NEJM199910283411804.
  • 15. Magro F, Gionchetti P, Eliakim R, et al, Third European Evidence-based Consensus on Diagnosis and Management of Ul- cerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders. ECCO Guidelines 2017.
  • 16. Andersen NN, Jess T. Risk of cardiovascular disease in inflam- matory bowel disease. World J Gastrointest Pathophysiol 2014; 5(3): 359-65. doi: 10.4291/wjgp.v5.i3.359.
  • 17. Ganguli SC, Kamath MV, Redmond, et al. A comparison of autonomic function in patients with inflammatory bowel disease and in healthy controls. Neurogastroenterol Motil 2007; 12: 961- 7. doi: 10.1111/j.1365-2982.2007.00987.x.
  • 18. Coruzzi P, Castiglioni P, Parati G, et al, Autonomic cardiovas- cular regulation in quiescent ulcerative colitis and Crohn’s dis- ease. Eur J Clin Invest 2007; 37: 964-70. doi: 10.1111/j.1365- 2362.2007.01887.x.
  • 19. Mouzas IA, Pallis AG, Kochiadakis GE, et al. Autonomic im- balance during the day in patients with inflammatory bowel disease in remission, Evidence from spectral analysis of heart rate variability over 24 h. Dig Liver Dis 2002; 34, 775-80. doi: 10.1016/s1590-8658(02)80070-6.
  • 20. Straub RH, Antoniou E, Zeuner M, et al. Association of auto- nomic nervous hyperreflexia and systemic inflammation in pa- tients with Crohn’s disease and ulcerative colitis. J Neuroim- munol 1997; 80: 149-57. doi: 10.1016/s0165-5728(97)00150-1.
  • 21. Pierpont GL, Voth EJ. Assessing autonomic function by analysis of heart rate recovery from exercise in healthy subjects. Am J Cardiol. 2004; 94: 64-8. doi: 10.1016/j.amjcard.2004.03.032.
  • 22. Jouven X, Empana JP, Schwartz PJ, et al. Heart rate profile during exercise as a predictor of sudden death, N Engl J Med 2005; 352, 1951-8. doi: 10.1056/NEJMoa043012.
  • 23. Sarli B, Dogan Y, Poyrazoglu O, et al. Heart rate recovery is im- paired in patients with inflammatory bowel diseases. Med Princ Pract. 2016; 25: 363–7. doi: 10.1159/000446318.
APA Ünsal O, Beyan E, aydoğan ünsal y, Karakaya S, Bulur O, Dal K, Eser M, Uzman M (2023). Heart rate recovery in patients with inflammatory bowel disease in clinical remission. , 248 - 251. 10.5455/annalsmedres.2022.11.335
Chicago Ünsal Oktay,Beyan Esin,aydoğan ünsal yasemin,Karakaya Serdar,Bulur Oktay,Dal Kursat,Eser Murat,Uzman Metın Heart rate recovery in patients with inflammatory bowel disease in clinical remission. (2023): 248 - 251. 10.5455/annalsmedres.2022.11.335
MLA Ünsal Oktay,Beyan Esin,aydoğan ünsal yasemin,Karakaya Serdar,Bulur Oktay,Dal Kursat,Eser Murat,Uzman Metın Heart rate recovery in patients with inflammatory bowel disease in clinical remission. , 2023, ss.248 - 251. 10.5455/annalsmedres.2022.11.335
AMA Ünsal O,Beyan E,aydoğan ünsal y,Karakaya S,Bulur O,Dal K,Eser M,Uzman M Heart rate recovery in patients with inflammatory bowel disease in clinical remission. . 2023; 248 - 251. 10.5455/annalsmedres.2022.11.335
Vancouver Ünsal O,Beyan E,aydoğan ünsal y,Karakaya S,Bulur O,Dal K,Eser M,Uzman M Heart rate recovery in patients with inflammatory bowel disease in clinical remission. . 2023; 248 - 251. 10.5455/annalsmedres.2022.11.335
IEEE Ünsal O,Beyan E,aydoğan ünsal y,Karakaya S,Bulur O,Dal K,Eser M,Uzman M "Heart rate recovery in patients with inflammatory bowel disease in clinical remission." , ss.248 - 251, 2023. 10.5455/annalsmedres.2022.11.335
ISNAD Ünsal, Oktay vd. "Heart rate recovery in patients with inflammatory bowel disease in clinical remission". (2023), 248-251. https://doi.org/10.5455/annalsmedres.2022.11.335
APA Ünsal O, Beyan E, aydoğan ünsal y, Karakaya S, Bulur O, Dal K, Eser M, Uzman M (2023). Heart rate recovery in patients with inflammatory bowel disease in clinical remission. Annals of Medical Research, 30(2), 248 - 251. 10.5455/annalsmedres.2022.11.335
Chicago Ünsal Oktay,Beyan Esin,aydoğan ünsal yasemin,Karakaya Serdar,Bulur Oktay,Dal Kursat,Eser Murat,Uzman Metın Heart rate recovery in patients with inflammatory bowel disease in clinical remission. Annals of Medical Research 30, no.2 (2023): 248 - 251. 10.5455/annalsmedres.2022.11.335
MLA Ünsal Oktay,Beyan Esin,aydoğan ünsal yasemin,Karakaya Serdar,Bulur Oktay,Dal Kursat,Eser Murat,Uzman Metın Heart rate recovery in patients with inflammatory bowel disease in clinical remission. Annals of Medical Research, vol.30, no.2, 2023, ss.248 - 251. 10.5455/annalsmedres.2022.11.335
AMA Ünsal O,Beyan E,aydoğan ünsal y,Karakaya S,Bulur O,Dal K,Eser M,Uzman M Heart rate recovery in patients with inflammatory bowel disease in clinical remission. Annals of Medical Research. 2023; 30(2): 248 - 251. 10.5455/annalsmedres.2022.11.335
Vancouver Ünsal O,Beyan E,aydoğan ünsal y,Karakaya S,Bulur O,Dal K,Eser M,Uzman M Heart rate recovery in patients with inflammatory bowel disease in clinical remission. Annals of Medical Research. 2023; 30(2): 248 - 251. 10.5455/annalsmedres.2022.11.335
IEEE Ünsal O,Beyan E,aydoğan ünsal y,Karakaya S,Bulur O,Dal K,Eser M,Uzman M "Heart rate recovery in patients with inflammatory bowel disease in clinical remission." Annals of Medical Research, 30, ss.248 - 251, 2023. 10.5455/annalsmedres.2022.11.335
ISNAD Ünsal, Oktay vd. "Heart rate recovery in patients with inflammatory bowel disease in clinical remission". Annals of Medical Research 30/2 (2023), 248-251. https://doi.org/10.5455/annalsmedres.2022.11.335