Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?
Yıl: 2022 Cilt: 12 Sayı: 4 Sayfa Aralığı: 793 - 798 Metin Dili: İngilizce DOI: 10.33808/clinexphealthsci.832112 İndeks Tarihi: 08-04-2023
Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?
Öz: Objective: To compare serum uric acid concentrations, pain and well-being in patients having chronic musculoskeletal pain with and without MetS, and investigate cut-off values. Methods: Patients having chronic musculoskeletal pain with (MetS group, n=48) and without MetS (control group, n=52) were included. The serum uric acid concentration, pain intensity, body composition, physical activity level, quality of life, and psychological status were evaluated by a uric acid blood test, Visual Analogue Scale, Bio-impedance Analyzer, International Physical Activity Questionnaire-7 (IPAQ-7), Nottingham Health Profile, and Hospital Anxiety and Depression Scale, respectively. Results: Uric acid level, fat mass, waist/hip ratio were found higher in the MetS group in comparison to the control group (P<0.05). It was seen that patients in the MetS group had lower physical activity levels than those in the control group (P<0.05). The cut-off points of the uric acid level, fat mass, waist/hip ratio, and physical activity level for detecting MetS were found as 5.25 mg/dl, 37.50 kg, 0.91, and 247.25 METs- minutes/week, respectively. Conclusion: Patients with MetS had a greater uric acid level, fat mass, waist/hip ratio, and a lower physical activity level than those without MetS. The increase of uric acid level, fat mass, and waist/hip ratio, and the decrease of physical activity may be critical for patients having musculoskeletal pain with MetS. These results should be considered for the management of these patients.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Alberti KGM, Zimmet P, Shaw J. The metabolic syndrome-a new worldwide definition. The Lancet 2005;366(9491):1059-1062.
- De Raaij EJ, Ostelo RW, Maissan F, Mollema J, Wittink H. The association of illness perception and prognosis for pain and physical function in patients with noncancer musculoskeletal pain: A systematic literature review. J Orthop Sports Phys Ther. 2018;48(10):789-800.
- Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D. Metabolic syndrome and risk of cancer: a systematic review and metaanalysis. Diabetes Care. 2012;35(11):2402-2411.
- Li H, George DM, Jaarsma RL, Mao X. Metabolic syndrome and components exacerbate osteoarthritis symptoms of pain, depression and reduced knee function. Ann Transl Med. 2016;4(7):133.
- Loevinger BL, Muller D, Alonso C, Coe CL. Metabolic syndrome in women with chronic pain. Metabolism 2007;56(1):87-93.
- Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H,Oka H, Minamide A, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M. Metabolic syndrome components are associated with intervertebral disc degeneration: The wakayama spine study. PloS One 2016;11(2):e0147565.
- Pietrzak M. Adhesive capsulitis: An age related symptom of metabolic syndrome and chronic low-grade inflammation? Med Hypotheses. 2016;88:12-17.
- Collins KH, Herzog W, MacDonald GZ, Reimer RA, Rios JL, Smith IC, Zernicke RF, Hart DA. Obesity, metabolic syndrome, and musculoskeletal disease: Common inflammatory pathways suggest a central role for loss of muscle integrity. Front Physiol. 2018;9:112.
- Kawamoto R, Ninomiya D, Kasai Y, Senzaki K, Kusunoki T, Ohtsuka N, Kumagi T. Baseline and changes in serum uric acid independently predict 11-year incidence of metabolic syndrome among community-dwelling women. J Endocrinol Invest. 2018;41(8):959-968.
- Sautin YY, Johnson RJ. Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids 2008;27(6):608-619.
- Kaushal N, Vohora D, Jalali RK, Jha S. Raised serum uric acid is associated with higher bone mineral density in a crosssectional study of a healthy Indian population. Ther Clin Risk Manag. 2018;14:75-82.
- Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Abeles M, Clark P, Fam AG, Farber SJ, Fiechtner JJ, Franklin CM, Gatter RA, Hamaty D, Lessard J, Lichtbroun AS, Masi AT, Mccain GA, Reynolds WJ, Romano TJ, Russell IJ, Sheon RP. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33(2):160-172.
- Mitani G, Nakamura Y, Miura T, Harada Y, Sato M, Watanabe M. Evaluation of the association between locomotive syndrome and metabolic syndrome. J Orthop Sci. 2018;23(6):1056-1062.
- Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486-2497.
- Meeuwsen S, Horgan GW, Elia M. The relationship between BMI and percent body fat, measured by bioelectrical impedance, in a large adult sample is curvilinear and influenced by age and sex. Clin Nutr. 2010;29(5):560-566.
- Saglam M, Arikan H, Savci S, Inal-Ince D, Bosnak-Guclu M, Karabulut E, Tokgozoglu L. International physical activity questionnaire: reliability and validity of the Turkish version. Percept Mot Skills. 2010;111(1):278-284.
- Clark P, Lavielle P, Martínez H. Learning from pain scales: patient perspective. J Rheumatol. 2003;30(7):1584-1588
- Kücükdeveci AA, McKenna SP, Kutlay S, Gürsel Y, Whalley D, Arasil T. The development and psychometric assessment of the Turkish version of the Nottingham Health Profile. Int J Rehabil Res. 2000;23(1):31-38.
- Aydemir Ö, Guvenir T, Kuey L, Kultur S. Validity and reliability of Turkish version of hospital anxiety and depression scale. Turk Psikiyatri Derg. 1997;8(4):280-287.
- Afzal N, Mahmud TE, Jahan SS, Kundi S. Uric acid profile in patients with chronic nonspecific musculoskeletal pain. J Ayub Med Coll Abbottabad:JAMC 2003;15(4):5-9.
- Fu YQ, Yang H, Zheng JS, Zeng XY, Zeng W , Fan ZF, Chen M, Wang L, Li D. Positive association between metabolic syndrome and serum uric acid in Wuhan. Asia Pac J Clin Nutr. 2017;26(2):343-350.
- Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med. 2003;163(4):427-436.
- Lee DH, Kim YM, Jekal Y, Park S, Kim KC, Naruse M, Kim SH, Kim SH, Park JH, Lee MK, Chu SH, Jeon JY. Low levels of physical activity are associated with increased metabolic syndrome risk factors in korean adults. Diabetes Metab J. 2013;37(2):132-139.
- Han JH, Park HS, Shin CI, Chang HM, Yun KE, Cho SH, Choi EY, Lee SY, Kim JH, Sung HN, Kim JH, Choi SI, Yoon YS , Lee ES, Song HR, Bae SC. Metabolic syndrome and quality of life (QOL) using generalised and obesity-specific QOL scales. Int J Clin Pract. 2009;63(5):735-741.
- Miettola J, Niskanen LK, Viinamäki H, Sintonen H, Kumpusalo E. Metabolic syndrome is associated with impaired healthrelated quality of life: Lapinlahti 2005 study. Qual Life Res. 2008;17(8):1055-1062.
- Vetter ML, Wadden TA, Lavenberg J, Moore RH, Volger S, Perez JL, Sarwer DB, Tsai AG. Relation of health-related quality of life to metabolic syndrome, obesity, depression and comorbid illnesses. Int J Obes. 2011;35(8):1087-1094.
- Akbaraly TN, Kivimäki M, Brunner EJ, Chandola T, Marmot MG, Singh-Manoux A, Ferrie JE. Association between metabolic syndrome and depressive symptoms in middleaged adults: results from the Whitehall II study. Diabetes Care 2009;32(3):499-504.
- Räikkönen K, Matthews KA, Kuller LH. Depressive symptoms and stressful life events predict metabolic syndrome among middle-aged women: A comparison of World Health Organization, Adult Treatment Panel III, and International Diabetes Foundation Definitions. Diabetes Care 2007;30(4):872-877.
- Skilton MR, Moulin P, Terra JL, Bonnet F. Associations between anxiety, depression, and the metabolic syndrome. Biol Psychiatry 2007;62(11):1251-1257.
- Hildrum B, Mykletun A, Midthjell K, Ismail K, Dahl AA. No association of depression and anxiety with the metabolic syndrome: the Norwegian HUNT study. Acta Psychiatr Scand. 2009;120(1):14-22.
| APA | Toprak Celenay S, Ozer Kaya D, Sas S (2022). Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?. , 793 - 798. 10.33808/clinexphealthsci.832112 |
| Chicago | Toprak Celenay Seyda,Ozer Kaya Derya,Sas Senem Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?. (2022): 793 - 798. 10.33808/clinexphealthsci.832112 |
| MLA | Toprak Celenay Seyda,Ozer Kaya Derya,Sas Senem Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?. , 2022, ss.793 - 798. 10.33808/clinexphealthsci.832112 |
| AMA | Toprak Celenay S,Ozer Kaya D,Sas S Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?. . 2022; 793 - 798. 10.33808/clinexphealthsci.832112 |
| Vancouver | Toprak Celenay S,Ozer Kaya D,Sas S Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?. . 2022; 793 - 798. 10.33808/clinexphealthsci.832112 |
| IEEE | Toprak Celenay S,Ozer Kaya D,Sas S "Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?." , ss.793 - 798, 2022. 10.33808/clinexphealthsci.832112 |
| ISNAD | Toprak Celenay, Seyda vd. "Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?". (2022), 793-798. https://doi.org/10.33808/clinexphealthsci.832112 |
| APA | Toprak Celenay S, Ozer Kaya D, Sas S (2022). Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?. Clinical and Experimental Health Sciences, 12(4), 793 - 798. 10.33808/clinexphealthsci.832112 |
| Chicago | Toprak Celenay Seyda,Ozer Kaya Derya,Sas Senem Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?. Clinical and Experimental Health Sciences 12, no.4 (2022): 793 - 798. 10.33808/clinexphealthsci.832112 |
| MLA | Toprak Celenay Seyda,Ozer Kaya Derya,Sas Senem Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?. Clinical and Experimental Health Sciences, vol.12, no.4, 2022, ss.793 - 798. 10.33808/clinexphealthsci.832112 |
| AMA | Toprak Celenay S,Ozer Kaya D,Sas S Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?. Clinical and Experimental Health Sciences. 2022; 12(4): 793 - 798. 10.33808/clinexphealthsci.832112 |
| Vancouver | Toprak Celenay S,Ozer Kaya D,Sas S Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?. Clinical and Experimental Health Sciences. 2022; 12(4): 793 - 798. 10.33808/clinexphealthsci.832112 |
| IEEE | Toprak Celenay S,Ozer Kaya D,Sas S "Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?." Clinical and Experimental Health Sciences, 12, ss.793 - 798, 2022. 10.33808/clinexphealthsci.832112 |
| ISNAD | Toprak Celenay, Seyda vd. "Does the Presence of Metabolic Syndrome Alter Serum Uric Acid Concentrations, Pain, and Well-Being in Patient with Chronic Musculoskeletal Pain?". Clinical and Experimental Health Sciences 12/4 (2022), 793-798. https://doi.org/10.33808/clinexphealthsci.832112 |
