Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features
Yıl: 2022 Cilt: 12 Sayı: 4 Sayfa Aralığı: 830 - 834 Metin Dili: İngilizce DOI: 10.33808/clinexphealthsci.1055921 İndeks Tarihi: 08-04-2023
Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features
Öz: Objective: In this study, it was aimed to prepare nanoparticle formulations using chitosan, a cationic natural polymer, and tripoly phosphate, and to perform mechanical characterization and in vitro cell culture studies. In addition, the cytotoxic effects of nanoparticles containing indenopyrazol derivatives against human glioma cells (C6) and human cervical cancer cells (HeLa) were investigated. Methods: Within the scope of the study, nanoparticles containing indenopyrazole derivative were prepared and characterization of particle size, zeta potential and morphological properties were performed. XTT cytotoxicity test was applied to evaluate the antiproliferative activities of nanoparticles containing these components. Results: Particle size, zeta potential and morphological properties of nanoparticles were observed to be suitable for application. In vitro cell culture studies showed that nanoparticles containing indenopyrazol derivatives showed better cytotoxic effects in both cell lines. Conclusion: The results showed that the mechanical properties of nanoparticles containing indenopyrazol derivatives are suitable and can be applied in anticancer activity studies.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Doğan M, Kocyigit U, Gezegen H (2022). Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features. , 830 - 834. 10.33808/clinexphealthsci.1055921 |
| Chicago | Doğan Murat,Kocyigit Umit Muhammet,Gezegen Hayreddin Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features. (2022): 830 - 834. 10.33808/clinexphealthsci.1055921 |
| MLA | Doğan Murat,Kocyigit Umit Muhammet,Gezegen Hayreddin Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features. , 2022, ss.830 - 834. 10.33808/clinexphealthsci.1055921 |
| AMA | Doğan M,Kocyigit U,Gezegen H Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features. . 2022; 830 - 834. 10.33808/clinexphealthsci.1055921 |
| Vancouver | Doğan M,Kocyigit U,Gezegen H Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features. . 2022; 830 - 834. 10.33808/clinexphealthsci.1055921 |
| IEEE | Doğan M,Kocyigit U,Gezegen H "Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features." , ss.830 - 834, 2022. 10.33808/clinexphealthsci.1055921 |
| ISNAD | Doğan, Murat vd. "Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features". (2022), 830-834. https://doi.org/10.33808/clinexphealthsci.1055921 |
| APA | Doğan M, Kocyigit U, Gezegen H (2022). Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features. Clinical and Experimental Health Sciences, 12(4), 830 - 834. 10.33808/clinexphealthsci.1055921 |
| Chicago | Doğan Murat,Kocyigit Umit Muhammet,Gezegen Hayreddin Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features. Clinical and Experimental Health Sciences 12, no.4 (2022): 830 - 834. 10.33808/clinexphealthsci.1055921 |
| MLA | Doğan Murat,Kocyigit Umit Muhammet,Gezegen Hayreddin Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features. Clinical and Experimental Health Sciences, vol.12, no.4, 2022, ss.830 - 834. 10.33808/clinexphealthsci.1055921 |
| AMA | Doğan M,Kocyigit U,Gezegen H Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features. Clinical and Experimental Health Sciences. 2022; 12(4): 830 - 834. 10.33808/clinexphealthsci.1055921 |
| Vancouver | Doğan M,Kocyigit U,Gezegen H Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features. Clinical and Experimental Health Sciences. 2022; 12(4): 830 - 834. 10.33808/clinexphealthsci.1055921 |
| IEEE | Doğan M,Kocyigit U,Gezegen H "Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features." Clinical and Experimental Health Sciences, 12, ss.830 - 834, 2022. 10.33808/clinexphealthsci.1055921 |
| ISNAD | Doğan, Murat vd. "Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features". Clinical and Experimental Health Sciences 12/4 (2022), 830-834. https://doi.org/10.33808/clinexphealthsci.1055921 |
