TY  - JOUR
TI  - Efficacy of Colistin Therapy in Patients with Hematological Malignancies: What if There is Colistin Resistance?
AB  - Objective: The objective of this study was to evaluate the clinical efficacy and appropriateness of colistin therapy in patients with  hematological malignancies. Methods: Age, gender, type of hematologic malignancy, and potential carbapenem-resistant microorganism risk factors were  all noted in this retrospective study. In empirical and agent-specific treatment groups, differences in demographic features, risk  factors, treatment responses, and side effects were compared. Results: Sixty-three patients were included, 54% were male, and the median age was 49. In the last three months, the hospital ization rate history was 68%, and four patients had a hospitalization history in the ICU. Carbapenem-resistant K. pneumoniae col onization was present in 22 patients (35%). Gram-negative microorganisms were isolated in 34 patients (54%). The carbapenem,  quinolone, and colistin resistance rates were 82%, 76%, and 4% respectively. Clinical and microbiological response rates were 60%  and 69%. 7 and 28-day mortality rates were 17% and 35%. There was no significant difference in demographic data and comorbid ities in empirical (n=48) and agent-specific (n=15) treatment groups. The rate of carbapenem and glycopeptide treatments before  colistin was higher in the empirical treatment group (p = 0.004; p = 0.001). The rate of starting combined antibiotics was higher in  the empirical treatment group (p = 0.016). Two of the patients developed renal failure in the first week after treatment. Conclusion: The use of empirical colistin may be unavoidable given the risk considerations. Shortly, colistin-resistant strains may  also be a factor affecting treatment success negatively.
AU  - kahveci, hüseyin nadir
AU  - TÜRE, Zeynep Ture
AU  - Ulu Kılıç, Aysegul
AU  - Kalin Unuvar, Gamze
AU  - Keklik, Muzaffer
DO  - 10.58600/eurjther-340
PY  - 2023
JO  - European Journal of Therapeutics
VL  - 29
IS  - 1
SN  - 2564-7784
SP  - 17
EP  - 22
DB  - TRDizin
UR  - http://search/yayin/detay/1163270
ER  -