TY  - JOUR
TI  - Does the plasma vitamin D level affect the severity of infection in COVID-19 patients of different age groups?
AB  - Purpose: SARS-CoV-2 has caused an on-going global pandemic of COVID-19 disease. Vitamin-D has an immunomodulatory effect on the disease by suppressing the adaptive immune system which can lead to a cytokine storm, and boosting the innate immune system. This study evaluated the relationship between both the clinical characteristics of COVID-19 patients and the severity of their infections, and their serum Vitamin D levels. Material and Methods: Forty COVID-19 patients from the period April to July, 2020, and 46 healthy subjects from a similar period in 2019, were included. Serum Vitamin-D level, Clinical findings, comorbidities, chest computed tomography findings, hematological and serum biochemistry analyzes of the patients were evaluated. Results: COVID-19 patients had a significantly lower mean serum 25(OH) Vitamin-D level (12·86 ± 6·27 ng/mL) than healthy subjects (25·4 ± 12·7 ng/mL) (p<<0·001). The prevalence of Vitamin D deficiency in COVID-19 patients was high, not only in the elderly, but also in middle age and young patients. Ground-glass opacification and paving stone sign were the most frequent patterns observed in chest-computed tomography (CT) images. There was a significant negative relationship between Vitamin-D deficiency and C-reactive protein (CRP) level (p=0·0243). In addition, a high CRP level was associated with abnormal CT findings (p=0·001).  Conclusion: The authors conclude that determining the Vitamin-D level in COVID-19 patients and administering it at the appropriate dosage can reduce the severity and progression of COVID-19 disease by contributing to the regulation of the cytokine storm and pulmonary inflammatory response.
AU  - Gökmen, Sedat
AU  - Uslu, Vedide Rezan
AU  - Kuruoglu, Tuba
AU  - Temoçin, Fatih
AU  - Güvenç, Dilek
AU  - atilla, aynur
AU  - AVCI, BAHATTIN
DO  - 10.31362/patd.1080912
PY  - 2022
JO  - Pamukkale Tıp Dergisi
VL  - 15
IS  - 3
SN  - 1309-9833
SP  - 499
EP  - 512
DB  - TRDizin
UR  - http://search/yayin/detay/1163611
ER  -