Yıl: 2023 Cilt: 15 Sayı: 2 Sayfa Aralığı: 307 - 322 Metin Dili: İngilizce DOI: 10.18863/pgy.1110989 İndeks Tarihi: 22-04-2023

Transdiagnostic Approach and Obsessive Compulsive Disorder

Öz:
The categorical approach of traditional psychiatric nosology has been a forceful approach for a very long time for explaining psychological disorders which are defined by symptom based diagnostic categories. However, in recent years, the importance of the "transdiagnostic" approach which is a new classification system is increasing. The transdiagnostic approach aims to examine dimensionally the common cognitive, behavioral, interpersonal and biological processes underlying many psychopathologies away from the categorical approach that classifies psychopathologies according to observable symptoms. This approach intends to treat the disorders through the common underlying processes and risk factors, thus heterogeneous and comorbid symptoms are better addressed and diagnostic categories that may change during treatment are avoided. In this review study, the current problems in diagnosing based on classification and gaps in the field were examined, and the approach itself was proposed as a solution. RDoC (Research Domain Criteria) which is a new classification system for psychiatric disorders within the scope of the approach, has created a new structure using modern research approaches in genetics, neuroscience and behavioral sciences. In the present study, the definition and emergence of the transdiagnostic approach, obsessive compulsive disorder and RDoC in the context of transdiagnostic approach and transdiagnostic treatment are explained. This review is intended to be a resource for both basic psychopathology research and the development of treatment methods within the framework of a transdiagnostic approach.
Anahtar Kelime: Transdiagnostic approach RDoC comorbidity obsessive compulsive disorder

Tanılar Üstü Yaklaşım ve Obsesif Kompulsif Bozukluk

Öz:
Psikiyatrik bozuklukların açıklanmasında geleneksel psikiyatrik nozolojinin kategorik yaklaşımı uzunca bir süredir hakim yaklaşım olmuş ve bozukluklar belirtilere dayalı tanı kategorileriyle tanımlanmıştır. Ancak son yıllarda geleneksel tanı sınırlarının ötesine uzanan yeni sınıflandırma sistemi olan "transdiagnostic" yani “tanılar üstü” yaklaşımın önemi giderek artmaktadır. Yaklaşım, psikopatolojileri gözlemlenebilir belirtilere göre sınıflandıran kategorik yaklaşımdan uzaklaşıp boyutsal olarak pek çok psikopatolojinin altında yatan ortak bilişsel, davranışsal, kişilerarası ve biyolojik süreçlerin incelenmesini amaçlamaktadır. Belirtilerin ötesinde bozuklukların altında yatan ortak süreçler ve risk faktörleri üzerinden tedavi etmeyi böylelikle heterojen ve eştanı belirtileri daha iyi ele alabilmeyi ve tedavi sırasında değişebilen tanı kategorilerinden uzak kalmayı hedeflemektedir. Bu derleme makalesi ile sınıflandırmaya dayalı tanı konmasındaki mevcut sorunların ne olduğu ve alandaki boşluklar incelenmiş, yaklaşımın kendisi bir çözüm önerisi olarak sunulmuştur. Bu kapsamda psikiyatrik bozukluklar için yeni bir sınıflandırma sistemi girişimi olan RDoC (Research Domain Criteria - Araştırma Alanı Ölçütleri); genetik, sinirbilim ve davranış bilimlerindeki modern araştırma yaklaşımlarını kullanarak yeni yapı ortaya koymuştur. Bu çalışmada tanılar üstü yaklaşımın tanımı ve ortaya çıkışı, tanılar üstü yaklaşım bağlamında obsesif kompulsif bozukluk ve RDoC, tanılar üstü tedavi yaklaşımı aktarılmıştır. Bu derleme çalışmasının tanılar üstü yaklaşım çerçevesinde hem temel psikopatoloji araştırmalarında hem de tedavi yöntemlerinin geliştirilmesinde kaynak olması amaçlanmıştır.
Anahtar Kelime: Tanılar üstü yaklaşım araştırma alanı ölçütleri eştanı obsesif kompulsif bozukluk

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • Adam Y, Meinlschmidt G, Gloster AT, Lieb R (2012) Obsessive- compulsive disorder in the community, 12- month prevalence, comorbidity and impairment. Soc Psychiatry Psychiatr Epidemiol, 47:339–349.
  • Admon R, Bleich-Cohen M, Weizmant R, Poyurovsky M, Faragian S, Hendler T (2012) Functional and structural neural indices of risk aversion in obsessive-compulsive disorder (OCD). Psychiatry Res, 203:207–213
  • Allen LB, Tsao JC, Seidman LC, Ehrenreich-May J, Zeltze LK (2012) A unified, transdiagnostic treatment for adolescents with chronic pain and comorbid anxiety and depression. Cogn Behav Pract, 19:56-67.
  • APA (2013) Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Washington, DC, American Psychiatric Association.
  • Anderzhanova E, Kirmeier T, Wotjak CT (2017) Animal models in psychiatric research: The RDOC system as a new framework for endophenotype-oriented translational neuroscience. Neurobiol Stress, 7:47–56.
  • Avery SN, Clauss JA, Blackford JU (2016) T he human BNST: Functional role in anxiety and addiction. Neuropsychopharmacology. 41:126–141.
  • Barlow DH, Allen LB, Choate ML (2004) Toward a unified treatment for emotional disorders. Behav Ther, 35:205-230.
  • Barlow DH, Ellard KK, Fairholme CP, Farchione TJ, Boisseau CL, Allen LB et al. (2011) The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: Client Workbook. New York, Oxford University Press.
  • Barlow DH, Farchione TJ, Bullis JR, Gallagher MW, Murray-Latin H, Sauer-Zavala S et al. (2017) The unified protocol for transdiagnostic treatment of emotional disorders compared with diagnosis-specific protocols for anxiety disorders: A randomized clinical trial. JAMA psychiatry, 74:875-884.
  • Barlow DH, Farchione TJ, Fairholme CP, Ellard KK, Boisseau CI, Allen LB et al. (2011) Unified protocol for transdiagnostic treatment of emotional disorders (therapist guide) New York, Oxford University Press.
  • Barlow DH, Lehman CL (1996) Advances in the psychosocial treatment of anxiety disorders, Implications for national health care. Arch Gen Psychiatry, 53:727–735.
  • Barlow DH, Sauer-Zavala S, Carl JR, Bullis JR, Ellard KK (2014) The nature, diagnosis, and treatment of neuroticism: Back to the future. Clin Psychol Sci, 2:344–365.
  • Bennett-Levy J, Butler G, Fennel M, Hackmann A, Mueller M, Westbrook D (2004) The Oxford Guide to Behavioural Experiments in Cognitive Therapy. New York, Oxford University Press.
  • Berking M, Wupperman P (2012) Emotion regulation and mental health, recent findings, current challenges, and future directions. Curr Opin Psychiatry, 25, 128-134.
  • Bersani G, Bersani FS, Valeriani G, Robiony M, Anastasia A, Colletti C. et al. (2012) Comparison of facial expression in patients with obsessive-compulsive disorder and schizophrenia using the Facial Action Coding System: A preliminary study. Neuropsychiatr Dis Treat, 8:537-547.
  • Bolton D, Gibb W, Lees A, Raven P, Gray JA, Chen E et al. (1998) Neurological soft signs in obsessive compulsive disorder: standardised assessment and comparison with schizophrenia. Behav Neurol, 11:197-204
  • Boswell JF, Anderson LM, Barlow DH (2014) An idiographic analysis of change processes in the unified transdiagnostic treatment of depression. J Consult Clin Psychol, 82:1060-1071.
  • Buckner JD, Keough ME, Schmidt NB (2007) Problematic alcohol and cannabis use among young adults, The roles of depression and discomfort and distress tolerance. Addict Behav, 32:1957–1963
  • Calhoon GG, Tye KM (2015) Resolving the neural circuits of anxiety. Nat Neurosci, 18:1394–1404.
  • Carpenter RW, Trul TJ (2013) Components of emotion dysregulation in borderline personality disorder, A review. Curr Psychiatry Rep, 15:335.
  • Cavanagh J, Shackman A. (2014) Frontal midline theta reflects anxiety and cognitive control: meta-analytic evidence. J Physiol Paris, 109:3–15.
  • Chen YW, Dilsaver SC (1995) Comorbidity for obsessivecompulsive disorder in bipolar and unipolar disorders. Psychiatry Res, 59:57–64
  • Craske MG (2012) Transdiagnostic treatment for anxiety and depression. Depress Anxiety, 29:749–753.
  • Cuthbert BN (2005) Dimensional models of psychopatholgy, Research agenda and clinical utility. J Abnorm Psychol, 114:565–569.
  • Cuthbert BN, Kozak MJ (2013) Constructing constructs for psychopathology, the NIMH research domain criteria. J Abnorm Psychol, 122:928–937.
  • Davis M, Walker DL, Miles L, Grillon C (2010) Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology, 35:105–135.
  • Dear BF, Staples LG, Terides MD, Karin E, Zou J, Johnston L et al. (2015) Transdiagnostic disorder-specific and clinician- guided, versus self-guided internet-delivered treatment for generalized anxiety disorder and comorbid disorders, a randomized controlled trial. J Anxiety Disord, 36,63-77.
  • DeRubeis RJ, Brotman MA, Gibbons CJ (2005) A conceptual and methodological analysis of the nonspecifics argument. Clin Psychol (New York), 12:174−183.
  • DeVeaugh-Geiss J (1993) Diagnosis and treatment of obsessive compulsive disorder. Annu Rev Med, 44:53-61.
  • Dickinson A. (1985) Actions and habits: The development of behavioral autonomy. Philos Trans R Soc Lond B Biol Sci, 308:67–78.
  • Douglas HM, Moffi TE, Dar R, McGee R, Silva P (1995) Obsessive- compulsive disorder in a birth cohort of 18- year- olds, prevalence and predictors. J Am Acad Child Adolesc Psychiatry, 34:1424 – 1431.
  • Dudley R, Kuyken W, Padesky CA (2011) Disorder specific and trans-diagnostic case conceptualisation. Clin Psychol Rev, 31:213-224.
  • Eaton NR, Rodriguez-Seijas C, Carragher N, Krueger RF (2015) Transdiagnostic factors of psychopathology and substanc use disorders, a review. J Affect Disord, 188:22-27.
  • Ellis A (1962) Reason and Emotion in Psychotherapy. Oxford, Lyle Stuart. Ellis AJ, Vanderlind WM, Beevers CG (2013) Enhanced anger reactivity and reduced distress tolerance in major depressive disorder. Cognit Ther Res, 37:498–509.
  • Elnazer HY, Baldwin DS (2014) Investigation of cortisol levels in patients with anxiety disorders: a structured review. Curr Top Behav Neurosci, 18:191–216.
  • Endrass T, Ullsperger M (2014) Specificity of performance monitoring changes in obsessive-compulsive disorder. Neurosci Biobehav Rev, 46: 124–138.
  • Enns MW, Cox BJ, Borger SC (2001) Correlates of analogue and clinical depression, A further test of the phenomenological continuity hypothesis. J Affect Disord, 66:175−183.
  • Fairburn CG, Cooper Z, Doll HA, O’Connor ME, Bohn K, Hawker DM (2009) Transdiagnostic cognitive-behavioral therapy for patients with eating disorders, a two-site trial with 60-week follow-up. Am J Psychiatry, 166:311–319.
  • Farchione TJ, Fairholme CP, Ellard KK, Boisseau CL, Thompson-Hollands J, Carl JR et al. (2012) Unified protocol for transdiagnostic treatment of emotional disorders, A randomized controlled trial. Behav Ther, 43:666-678.
  • Figee M, Pattij T, Willuhn I, Luigjes J, van den Brink W, Goudriaan A et al. (2016) Compulsivity in obsessive-compulsive disorder and addictions. Eur Neuropsychopharmacol, 26:856–868.
  • Fineberg NA, Apergis-Schoute AM, Vaghi MM, Banca P, Gillan CM, Voon V (2018) Mapping compulsivity in the DSM-5 obsessive compulsive and related disorders: cognitive domains, neural circuitry, and treatment. Int J Neuropsychopharmacol, 21:42-58.
  • Fink P, Ørnbøl E, Toft T, Sparle KC, Frostholm L, Olesen F (2004) A new, empirically established hypochondriasis diagnosis. Am J Psychiatry, 161:1680–1691.
  • Foa EB, Grayson JB, Steketee GS, Doppelt HG, Turner RM, Latimer PR (1983) Success and failure in the behavioral treatment of obsessive-compulsives. J Consult Clin Psychol, 51:287–297.
  • Fontenelle LF, Oldenhof E, Moreira-de-Oliveira ME, Abramowitz JS, Antony MM, Cath D et al. (2020) A transdiagnostic perspective of constructs underlying obsessive-compulsive and related disorders, an international Delphi consensus study Aust N Z J Psychiatry, 54:719-731.
  • Frank MJ, Woroch BS, Curran T (2005) Error-related negativity predicts reinforcement learning and conflict biases. Neuron, 47:495-501.
  • Fujisato H, Kato N, Namatame H, Ito M, Usami M, Nomura T et al. (2021) The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders among Japanese children: A pilot study. Front Psychol, 25:12.
  • Fusar-Poli P, Solmi M, Brondino N, Davies C, Chae C, Politi P et al. (2019) Transdiagnostic psychiatry, a systematic review. World Psychiatry, 18:192-207.
  • Glashouwer KA, Vroling MS, de Jong PJ, Lange WG, de Keijser J (2013) Low implicit self-esteem and dysfunctional automatic associations in social anxiety disorder. J Behav Ther Exp Psychiatry, 44:262–270.
  • Gillan CM, Fineberg NA, Robbins TW (2017) A trans-diagnostic perspective on obsessive-compulsive disorder. Psychol Med, 47:1528–1548.
  • Gillan C (2017) Habits and goals in OCD. In Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment (Ed C Pittenger):161-170. New York, Oxford University Press.
  • Goldner EM, Cockell SJ, Srikameswaran S (2002) Perfectionism and eating disorders. In Perfectionism, Theory, research, and treatment (Eds GL Flett, PL Hewitt):319–340. Washington DC, American Psychological Association.
  • Gorka SM, Ali B, Daughters SB (2012) The role of distress tolerance in the relationship between depressive symptoms and problematic alcohol use. Psychol Addict Behav, 26:621–626.
  • Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry, 160:636-45.
  • Graybiel AM (2008) Habits, rituals, and the evaluative brain. Annu Rev Neurosci, 31:359–387.
  • Goschke T (2014) of decision-making and cognitive control as transdiagnostic mechanisms of mental disorders, Advances, gaps, and needs in current research. Int J Methods Psychiatry, 23:41–57.
  • Gratz KL, Weiss NH, Tull MT (2015) Examining emotion regulation as an outcome, mechanism, or target of psychological treatments. Curr Opin Psychology, 3:85-90.
  • Grupe DW, Nitschke JB (2013) Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective. Nat Rev Neurosci, 14:488–501.
  • Haber SN (2017) Neurocircuitry underlying obsessive-compulsive disorder: Neural networks underlying reward and action selection. In Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment (Ed C Pittenger):201-211. New York, Oxford University Press.
  • Harvey AG (2002) Trouble in bed, The role of pre–sleep worry and intrusions in the maintenance of insomnia. J Cogn Psychother, 16:161–177.
  • Harvey A, Murray G, Chandler R., Soehner A. (2011) Sleep disturbance as transdiagnostic, Consideration of neurobiological mechanisms. Clin Psychol Rev, 31:225–235.
  • Harvey AG, Watkins E, Mansell W, Shafran R (2004) Cognitive Behavioural Processes Across Psychological Disorders: A Transdiagnostic Approach to Research and Treatment. New York, Oxford University Press.
  • Hewitt PL, Flett GL (1991) Perfectionism in the self and social contexts, Conceptualization, assessment and association with psychopathology. J Pers Soc Psychol, 60:456−470.
  • Hewitt PL, Flett GL (1993) Dimensions of perfectionism, daily stress, and depression, a test of the specific vulnerability hypothesis. J Abnorm Psychol, 102:58-65.
  • Hogue A, Dauber S (2013) Diagnostic profiles among urban adolescents with unmet treatment needs, comorbidity and perceived need for treatment. J Emot Behav Disord, 21:18-32.
  • Hohagen F, Lis S, Krieger S, Winkelmann G, Riemann D, Fritsch-Montero R et al. (1994) Sleep EEG of patients with obsessive- compulsive disorder. Eur Arch Psychiatry Clin Neurosci, 243:273–8.
  • Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K et al. (2010) Research domain criteria (RDOC): toward a new classification framework for research on mental disorders. Am J Psychiatry, 167:748–751.
  • Jackson PL, Meltzoff AN, Decety J (2005) How do we perceive the pain of others? A window into the neural processes involved in empathy. Neuroimage, 24:771–779.
  • Jacoby RJ, Abramowitz JS (2017) Intolerance of uncertainty. In Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment (Ed C Pittenger):171-178. New York, Oxford University Press.
  • Juster HR, Heimberg RG, Frost RO, Holt CS, Mattia JI, Faccenda K (1996) Social phobia and perfectionism. Pers Individ Dif, 21:403–410.
  • Kalanthroff E, Anholt GE & Simpson HB(2017) Research domain criteria and OCD: An oxymoron? In Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment (Ed C Pittenger):689-702. New York, Oxford University Press.
  • Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age- of- onset distributions of DSM- IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry, 62:593–602.
  • Kluge M, Schüssler P, Dresler M, Yassouridis A, Steiger A (2007) Sleep onset REM periods in obsessive compulsive disorder. Psychiatry Res, 30:29-35.
  • Kring AM, Sloan DS (2009) Emotion Regulation and Psychopathology, A Transdiagnostic Approach to Etiology and Treatment. New York, Guilford Press.
  • Kozak MJ, Cuthbert BN (2016) The NIMH Research Domain Criteria initiative: Background, issues, and pragmatics. Psychophysiology, 53:286–297.
  • Laposa JM, Mancuso E, Abraham G. & Loli-Dano L (2017) Unified protocol transdiagnostic treatment in group format, A preliminary investigation with anxious individuals. Behav Modif, 4:253-268.
  • Lopez ME, Stoddard JA, Noorollah A, Zerbi G, Payne LA, Hitchcock CA et al. (2015) Examining the efficacy of the unified protocol for transdiagnostic treatment of emotional disorders in the treatment of individuals with borderline personality disorder. Cogn Behav Pract, 22:522-533.
  • Macatee RJ, Capron DW, Schmidt NB, Cougle JR (2013) An examination of low distress tolerance and life stressors as factors underlying obsessions. J Psychiatr Res, 47:1462–1468.
  • Maj M (2016) Narrowing the gap between ICD/ DSM and RDOC constructs, possible steps and caveats. World Psychiatry. 15:193-194.
  • Mancusi L, McKay D, & Olatunji B. (2017) Disgust and obsessive-compulsive disorder In Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment (Ed C Pittenger):101-112. New York, Oxford University Press.
  • Manoach DS, Agam Y (2013) Neural markers of errors as endophenotypes in neuropsychiatric disorders. Front Human Neurosci, 7:350.
  • Mansell W, Harvey A, Watkins E, Shafran R (2009) Conceptual foundations of the transdiagnostic approach to CBT. J Cogn Psychother, 23:6–19.
  • McEvoy PM. & Nathan P (2007) Effectiveness of cognitive behavior therapy for diagnostically heterogeneous groups, A benchmarking study. J Consult Clin Psychol, 75:344−350.
  • McEvoy PM, Nathan P, Norton PJ (2009) Efficacy of transdiagnostic treatments, A review of published outcome studies and future research directions. J Cogn Psychother, 23:20–33.
  • McEvoy PM, Watson H, Watkins, ER, Nathan P (2013) The relationship between worry, rumination, and comorbidity, Evidence for repetitive negative thinking as a transdiagnostic construct. J Affect Disord, 151:313–320.
  • McManus F, Shafran R., Cooper Z. (2010) What does a “transdiagnostic” approach have to offer the treatment of anxiety disorders? Br J Clin Psychol, 49:491–505.
  • Mills RK, Murray HW, Barlow DH (2009) Balancing fidelity and adaptation in the dissemination of empirically-supported treatments, The promise of transdiagnostic interventions. Behav Res Ther, 47:946-953.
  • Miles L, Davis M, Walker D (2011) Phasic and sustained fear are pharmacologically dissociable in rats. Neuropsychopharmacology, 36:1563–1574.
  • Mills K, Marel C (2013) International data on the prevalence and correlates of comorbid substance use and psychiatric disorders. In Principles of Addition, Comprehensive Addictive Behaviours and Disorders Vol.1 (Ed P Miller):481-488. London, UK, Academic Press.
  • Minzenberg MJ, Gomes GC, Yoon JH, Swaab TY, Carter CS (2014) Disrupted action monitoring in recent-onset psychosis patients with schizophrenia and bipolar disorder. Psychiatry Res, 221:114–121
  • Mirdamadi M, Izadi F (2022) The effectiveness of transdiagnostic treatment on anxiety sensitivity, thought fusion and reduction of symptoms in people w ith obsessive-compulsive disorder. Research in Clinical Psychology and Counseling, 11:57-76.
  • Moor S, Vartanian LR, Touyz SW, Beumont PJV (2004) Psychopathology of EDNOS patients: To whom do they compare? Clin Psychol (Aust Psychol Soc), 8:70−75.
  • Moser JS, Moran TP, Schroder HS, Donnellan MB, Yeung N (2013) On the relationship between anxiety and error monitoring: a meta-analysis and conceptual framework. Front Hum Neurosci, 7:466.
  • Mowrer OH (1947) On the dual nature of learning—A re-interpretation of conditioning and problem-solving. Harv Educ Rev, 17:102–148.
  • Newby JM, Mackenzie A, Williams AD, McIntyre K, Watts S, Wong A et al. (2013) Internet cognitive behavioural therapy for mixed anxiety and depression, a randomized controlled trial and evidence of effectiveness in primary care. Psychol Med, 43:2635–2648.
  • Newby JM, McKinnon A, Kuyken W, Gilbody S, Dalgleish T (2015) Systematic review and meta analysis of transdiagnostic psychological treatments for anxiety and depressive disorders in adulthood. Clin Psychol Rev, 40:91 110.
  • NIHM (2018) The National Institute of Mental Health. RDOC Matrix. https://www.nimh.nih.gov/research/research- funded-by-nimh/RDoC/constructs/RDOC-matrix (Accessed 3.2.2022)
  • NIHM (2019) The National Institute of Mental Health. RDoC Matrix. https://www.nimh.nih.gov/research/research-funded- by-nimh/RDOC/constructs/sensorimotor-systems. (Accessed 3.2.2022)
  • Norton PJ (2008) An open trial of transdiagnostic cognitive–behavioral group therapy for anxiety disorders. Behav Ther, 39:242−250.
  • Norton PJ (2012) A randomized clinical trial of transdiagnostic CBT for anxiety disorder by comparison to relaxation training. Behav Ther, 43:506–517
  • Norton PJ, Barrera TL (2012) Transdiagnostic,versus diagnosis-specific CBT for anxiety disorders, A preliminary randomized controlled trial. Depress Anxiety, 29:874–882.
  • Norton PJ, Hayes SA, Hope DA (2004) Effects of a transdiagnostic group treatment for anxiety on secondary depressive disorders. Depression and Anxiety, 20:198−202
  • Norton PJ, Hayes SA, Springer JR (2008) Transdiagnostic cognitive-behavioral group therapy for anxiety, Outcome and process. Int J Cogn Ther, 1:266−279.
  • Norton PJ, Paulus DJ (2016) Towards a unified treatment for emotional disorders, Update on the science and practice. Behav Ther, 47:854–868.
  • Norton PJ, Philipp LM (2008) Transdiagnostic approaches to the treatment of anxiety disorders, A quantitative review. Psychotherapy (Chic), 45:214−226.
  • Nota JA, SharkeyKM, Coles ME (2015) Sleep, arousal, and circadian rhythms in adults with obsessive–compulsive disorder: A meta-analysis. Neurosci Biobehav Rev, 51:100–107.
  • Obsessive Compulsive Cognitions Working Group (1997) Cognitive assessment of obsessivecompulsive disorder. Behav Res Ther, 35:667-681.
  • O’Cleirigh CO, Ironson G (2007) Does distress tolerance moderate the impact of major life events on psychosocial variables and behaviors important in the management of HIV? Behav Ther, 38:314–323.
  • Olatunji BO, Wolitzky-Taylor KB (2009) Anxiety sensitivity and the anxiety disorders, A meta-analytic review and synthesis. Psychol Bull, 135:974–999.
  • Padesky CA, Greenberger D (1995) Clinician's Guide to Mind Over Mood. New York, Guilford Press.
  • Pallanti S, Barnes J, Pittenger C, & Eisen J (2017) Incompleteness and harm avoidance. In Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment (Ed C Pittenger):93-100. New York, Oxford University Press.
  • Pallanti S, Grassi G, Sarrecchia ED, Cantisani A, Pellegrini M (2011) Obsessive-compulsive disorder comorbidity, clinical assessment and therapeutic implications. Front Psychiatry, 2:70.
  • Paterson JL, Reynolds AC, Ferguson, SA, Dawson D (2013) Sleep and obsessive-compulsive disorder (OCD) Sleep Med Rev, 17:465-474.
  • Paulus DJ, Talkovsky AM, Heggeness LF, Norton PJ (2015) Beyond negative affectivity, A hierarchical model of global and transdiagnostic vulnerabilities for emotional disorders. Cogn Behav Ther, 44:389–405.
  • Pearl SB, Norton PJ (2017) Transdiagnostic,versus diagnosis specific cognitive behavioural therapies for anxiety, a meta- analysis. J Anxiety Disord, 46:11–24.
  • Pino MC, De Berardis D, Mariano Mallante F, Serroni N, Valchera A. et al. (2016) Two systems for empathy in obsessive- compulsive disorder: mentalizing and experience sharing. Braz J Psychiatry. 38:307-313.
  • Pittenger C, Gruner P, Adams TA, Kelmendi B (2017) Etiological models of OCD: Anxiety, obsession, compulsion, completeness. In Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment (Ed C Pittenger):669- 682. New York, Oxford University Press.
  • Pushkarskaya H, Tolin D, Ruderman L, Kirshenbaum A, Kelly JM, Pittenger C, Levy I. (2015) Decision-making under uncertainty in obsessive-compulsive disorder. J Psychiatr Res, 69:166–173.
  • Raines AM, Capron DW, Bontempo AC, Dane BF, Schmidt NB (2014) Obsessive compulsive symptom dimensions and suicide, The moderating role of anxiety sensitivity cognitive concerns. Cognit Ther Res, 38:660–669.
  • Rasmussen SA, Eisen JL (1992) The epidemiology and clinical features of obsessive compulsive disorder. Psychiatr Clin, 15:743-758.
  • Rector NA, Szacun-Shimizu K, Leybman M (2007) Anxiety sensitivity within the anxiety disorders, Disorder-specific sensitivities and depression comorbidity. Behav Res Ther, 25:1967– 1975.
  • Rector NA, Man V, Lerman B (2014) The expanding cognitive-behavioural therapy treatment umbrella for the anxiety disorders, Disorder-specific and transdiagnostic approaches. Can J Psychiatry, 59:301–309.
  • Reinholt N, Krogh J (2014) Efficacy of transdiagnostic cognitive behaviour therapy for anxiety disorders, a systematic review and meta-analysis of published outcome studies. Cogn Behav Ther, 43:171-184.
  • Reinholt N, Aharoni R, Winding C, Rosenberg N, Rosenbaum B, Arnfred S (2017) Transdiagnostic group CBT for anxiety disorders, The unified protocol in mental health services. Cogn Behav Ther, 46:29-43.
  • Riesel A, Klawohn J, Grützmann R, Kaufmann C, Heinzel S, Bey K et al. (2019) Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder. Psychol Med, 49:1207–1217.
  • Robbins TW, Gillan CM, Smith DG, de Wit S, Ersche KD (2012) Neurocognitive endophenotypes of impulsivity and compulsivity, towards dimensional psychiatry. Trends Cogn Sci 16: 81–91.
  • Robinson D, Walsleben J, Pollack S, Lerner G. (1998) Nocturnal polysomnography in obsessive-compulsive disorder. Psychiatry Res, 80:257–63.
  • Roemer L, Lee JK, Salters-Pedneault K, Erisman SM, Orsillo SM, Mennin DS (2009) Mindfulness and emotion regulation difficulties in generalized anxiety disorder, Preliminary evidence for independent and overlapping contributions. Behav Ther, 40:142–154.
  • Ruscio AM, Stein DJ, Chiu WT, Kessler RC (2010) The epidemiology of obsessive- compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry, 15:53-63.
  • Russo M, Naro A, Mastroeni C, Morgante F, Terranova C, Muscatello MR et al. (2014) Obsessive-compulsive disorder: A "sensory-motor" problem? Int J Psychophysiol, 92:74-78.
  • Saboonchi F, Lundh L, Ost L. (1999) Perfectionism and self-consciousness in social phobia and panic disorder with agoraphobia. Behav Res Ther, 37:799−808.
  • Saed O, Masjedi A, Taremian F, Bakhtyari M, Morsali Y (2015) The efficacy of Transdiagnostic Cognitive Behavior therapy on reducing symptoms severity of Obsessive Compulsive Disorder with co-occurring anxiety and mood disorders. International Journal of Applied Behavioral Sciences, 2(4):1-10.
  • Sassaroli S, Lauro LJR, Ruggiero GM, Mauri MC, Vinai P, Frost R (2008) Perfectionism in depression, obsessive–compulsive disorder and eating disorders. Behav Res Ther, 46:757−765.
  • Sauer-Zavala S, Gutner CA, Farchione TJ, Boettcher HT, Bullis JR, Barlow DH (2017) Current definitions of “transdiagnostic” in treatment development, A search for consensus. Behav Ther, 48:128-138.
  • Selby EA, Anestis M, Bender T, Joiner TE (2009) An exploration of the emotional cascade model in borderline personality disorder. J Abnorm Psychol, 118:375–387
  • Selby EA, Joiner TE (2009) Cascades of emotion, The emergence of borderline personality disorder from emotional and behavioral dysregulation. Rev Gen Psychol, 13:219–229.
  • Selby EA, Joiner TE (2013) Emotional cascades as prospective predictors of dysregulated behaviors in borderline personality disorder. Personal Disord, 4:168–174.
  • Shoan E, Hall K, Moulding R, Bryce S, Mildred H,Staiger PK (2017) Emotion regulation as a transdiagnostic treatment construct across anxiety, depression, substance, eating and borderlin personality disorders, A systematic review. Clin Psychol Rev, 57:141-163.
  • Smith KS, Graybiel AM (2016) Habit formation. Dialogues Clin Neurosci, 18:33–43.
  • Stiles WB, Barkham M, Mellor-Clark J, Connell J (2008) Effectivesss of cognitive behavioural, person-centered, and psychodynamic therapies in UK primary care routinepractice, Replicationwith a larger sample. Psychol Med, 38:677−688.
  • Storch EA, Wu MS, Small BJ, Crawford EA, Lewin AB, Horng B et al. (2014) Mediators and moderators of functional impairment in adults with obsessive– compulsive disorder. Compr Psychiatry, 55:489–496.
  • Şahin AE (2001) Eğitim araştırmalarında Delphi tekniği kullanımı. Hacettepe Üniversitesi Eğitim Fakültesi Dergisi, 20
  • Taylor S, Koch WJ, Woody S, McLean P (1996) Anxiety sensitivity and depression, How are they related. J Abnorm Psychol, 105:474–479.
  • Titov N, Andrews G, Johnston L, Robinson E, Spence J. (2010) Transdiagnostic internet treatment for anxiety disorders, A randomized controlled trial. Behav Res Ther, 48:890–899.
  • Tokimura H, Di Lazzaro V, Tokimura Y, Oliviero A, Profice P, Insola A et al. (2000) Short latency inhibition of human hand motor cortex by somatosensory input from the hand. J Physiol, 523:503-513.
  • Tolin DF, Worhunsky P, Maltby N (2006) Are “obsessive” beliefs specific to OCD?, A comparison across anxiety disorders. Behav Res Ther, 44:469-480.
  • Torres AR (2016) The road to improvement in obsessive-compulsive disorder. Lancet Psychiatry, 3:695–697.
  • Torres AR, Fontenelle LF, Shavitt RG, Ferrão YA, do Rosário MC, Storch EA et al. (2016) Comorbidity variation in patients with obsessive-compulsive disorder according to symptom dimensions, results from a large multicentre clinical sample. J Affect Disord, 190:508–516.
  • Tulbure BT, Rusu A, Sava FA, Sălăgean N, Farchione TJ (2018) A web-based transdiagnostic intervention for affective and mood disorders, Randomized controlled trial. JMIR Mental Health, 5:e36.
  • Tull MT, Gratz KL (2008) Further examination of the relationship between anxiety sensitivity and depression: The mediating role of experiential avoidance and difficulties engaging in g oal-directed behavior when distressed. J Anxiety Disord, 22:199–210.
  • Turk CL, Heimberg RG, Luterek JA, Mennin DS, Fresco DM (2005) Emotion dysregulation in generalized anxiety disorder, A comparison with social anxiety disorder. Cognit Ther Res, 29:89–106.
  • Ulaş H, Taşlıca S, Alptekin K (2008) Şizofrenide nörofizyolojik, nörokognitif genetik belirleyicilerin (endofenotip) yeri. Klinik Psikiyatri Dergisi, 11:12-19.
  • Valleni- Basile LA, Garrison CZ, Jackson KL, Waller JL, McKeown RE, Addy CL et al. (1994) Frequency of obsessive- compulsive disorder in a community sample of young adolescents. J Am Acad Child Adolesc Psychiatry. 33:782–791 .
  • Valleni-Basile LA, Garrison CZ, Jackson KL, Waller JL, McKeown RE, Addy CLet al. (2015) Disorders of compulsivity: a common bias towards learning habits. Mol Psychiatry, 20:345–352.
  • Wahl K, Ehring T, Kley H, Lieb R, Meyer A, Kordon A et al. (2019) Is repetitive negative thinking a transdiagnosticprocess? A comparison of key processes of RNT in depression, gener-alized anxiety disorder, obsessive-compulsive disorder, and communitycontrols. J Behav Ther Exp Psychiatry, 64:45–53.
  • Weinberg A, Dieterich R, Riesel A (2015) Error-related brain activity in the age of RDOC: a review of the literature. Int J Psychophysiol, 98:276–299
  • Weinberg A, Kotov R, Proudfit GH (2015) Neural indicators of error processing in generalized anxiety disorder, obsessive- compulsive disorder, and major depressive disorder. J Abnorm Psychol, 124:172–185
  • Weissman MM, Bland RC, Canino GJ, Greenwald S, Hwu HG, Lee CK et al. (1998) Crossnational epidemiology of obsessive- compulsive disorder. CNS Spectr, 3:6–9 .
  • Wheaton MG, Mahaffey B, Timpano KR, Berman,NC., Abramowitz JS (2012) The relationship between anxiety sensitivity and obsessive-compulsive symptom dimensions. J Behav Ther Exp Psychiatry, 43:891–896
  • Widiger TA, Clark LA. (2000) Toward DSM-V and the classification of psychopathology. Psychol Bull, 126:946–963.
  • Zavos HMS, Rijsdijk FV, Eley TC (2012) A longitudinal, genetically informative, study of associations between anxiety sensitivity, anxiety and depression. Behav Genet, 42:592–602.
  • Zeitlin SB, McNally RJ (1993) Alexithymia and anxiety sensitivity in panic disorder and obsessive-compulsive disorder. Am J Psychiatry, 150:658–660.
APA ozdemir e, Kargı A (2023). Transdiagnostic Approach and Obsessive Compulsive Disorder. , 307 - 322. 10.18863/pgy.1110989
Chicago ozdemir emre,Kargı A. Bikem Transdiagnostic Approach and Obsessive Compulsive Disorder. (2023): 307 - 322. 10.18863/pgy.1110989
MLA ozdemir emre,Kargı A. Bikem Transdiagnostic Approach and Obsessive Compulsive Disorder. , 2023, ss.307 - 322. 10.18863/pgy.1110989
AMA ozdemir e,Kargı A Transdiagnostic Approach and Obsessive Compulsive Disorder. . 2023; 307 - 322. 10.18863/pgy.1110989
Vancouver ozdemir e,Kargı A Transdiagnostic Approach and Obsessive Compulsive Disorder. . 2023; 307 - 322. 10.18863/pgy.1110989
IEEE ozdemir e,Kargı A "Transdiagnostic Approach and Obsessive Compulsive Disorder." , ss.307 - 322, 2023. 10.18863/pgy.1110989
ISNAD ozdemir, emre - Kargı, A. Bikem. "Transdiagnostic Approach and Obsessive Compulsive Disorder". (2023), 307-322. https://doi.org/10.18863/pgy.1110989
APA ozdemir e, Kargı A (2023). Transdiagnostic Approach and Obsessive Compulsive Disorder. Psikiyatride Güncel Yaklaşımlar, 15(2), 307 - 322. 10.18863/pgy.1110989
Chicago ozdemir emre,Kargı A. Bikem Transdiagnostic Approach and Obsessive Compulsive Disorder. Psikiyatride Güncel Yaklaşımlar 15, no.2 (2023): 307 - 322. 10.18863/pgy.1110989
MLA ozdemir emre,Kargı A. Bikem Transdiagnostic Approach and Obsessive Compulsive Disorder. Psikiyatride Güncel Yaklaşımlar, vol.15, no.2, 2023, ss.307 - 322. 10.18863/pgy.1110989
AMA ozdemir e,Kargı A Transdiagnostic Approach and Obsessive Compulsive Disorder. Psikiyatride Güncel Yaklaşımlar. 2023; 15(2): 307 - 322. 10.18863/pgy.1110989
Vancouver ozdemir e,Kargı A Transdiagnostic Approach and Obsessive Compulsive Disorder. Psikiyatride Güncel Yaklaşımlar. 2023; 15(2): 307 - 322. 10.18863/pgy.1110989
IEEE ozdemir e,Kargı A "Transdiagnostic Approach and Obsessive Compulsive Disorder." Psikiyatride Güncel Yaklaşımlar, 15, ss.307 - 322, 2023. 10.18863/pgy.1110989
ISNAD ozdemir, emre - Kargı, A. Bikem. "Transdiagnostic Approach and Obsessive Compulsive Disorder". Psikiyatride Güncel Yaklaşımlar 15/2 (2023), 307-322. https://doi.org/10.18863/pgy.1110989