TY  - JOUR
TI  - Safety Profiles of Biological Therapies Used in Asthma Treatment
AB  - The reliability of the biologics used in the treatment of severe asthma is as important as their effectiveness. There are currently six mAbs approved for the treatment of severe asthma (omalizumab, mepolizumab, benralizumab, reslizumab, dupilumab, and tezepelumab). In this review, the safety data obtained from clinical phase studies and real-life studies of these biologics are presented in detail together with our clinical experience. More real-life studies have been done with omalizumab and mepolizumab. It has been shown in these studies that their reliability profiles are quite good. A real-life study with tezepelumab has not been published so far. There are few real-life studies on benralizumab, dupilumab, and reslizumab. However, safety profiles in RCTs with these biologics have been reported similar to placebo. In clinical phase studies, it is seen that the safety profiles of all six biological treatments are quite good.
AU  - arslan, bahar
AU  - Yilmaz, Insu
AU  - ÇETİN, gülden
DO  - 10.21911/aai.091
PY  - 2022
JO  - Astım Allerji İmmünoloji
VL  - 20
IS  - 3
SN  - 1308-9234
SP  - 127
EP  - 141
DB  - TRDizin
UR  - http://search/yayin/detay/1165184
ER  -