The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease

ÇETİN, Aslı; ATICI, BUĞRAHAN; Uyumlu, Ayşe Burçin

doi:10.5455/annalsmedres.2022.04.118

The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease

Buğrahan ATICI, (İnönü Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalı, Malatya, Türkiye)

Ayşe Burçin UYUMLU, (İnönü Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalı, Malatya, Türkiye)

Aslı TAŞDEMİR (İnönü Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Malatya, Türkiye)

Annals of Medical Research

4 1

Yıl: 2022 Cilt: 29 Sayı: 12 Sayfa Aralığı: 1348 - 1353 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2022.04.118 İndeks Tarihi: 03-05-2023

The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease

Öz:

Aim: We intended to assess the hepatoprotective effects of phenethyl isothiocyanate (PEITC) against oxidative liver injury induced by a high-fat diet (HFD) and streptozotocin (STZ) diabetes through the Nuclear Factor E2-Related Factor 2 (Nrf2) and Sirtuin 1 (SIRT1) pathways in rats. Materials and Methods: Thirty male Wistar Albino rats were separated into three groups: the control group, the second group (HFD+STZ) fed HFD and injected with STZ (35mg/kg b.w.), and the third group (HFD+ STZ+PEITC) fed an HFD, injected with STZ (35mg/kg b.w.), and given PEITC (40mg/kg b.w. by oral gavage). Feeding with HFD and PEITC was given for two weeks and continued one more week following STZ. Serum ALT and lipids levels, antioxidant enzyme activities, MDA, GST, SIRT1, NF-κβ, and Nrf2 levels were measured. Liver histological changes were detected. Results: In comparison with the control group, in the HFD+STZ group, serum HDL levels, activities of hepatic antioxidant enzymes, Nrf2 activity, levels of GST, SIRT1, and NF-κβ reduced and besides, serum ALT, TG, TC, LDL / VLDL, and hepatic MDA levels increased (p <0.05). PEITC pre-administration led to improvement in these changes made by HFD-STZ (p <0.05). Conclusion: Our data presented that PEITC ameliorated hepatic injury and serum lipid profile induced by HFD and STZ via the activation of Nrf2 and SIRT1 pathways. We can suggest that PEITC could be a possible candidate agent against liver diseases.

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APA	ATICI B, Uyumlu A, ÇETİN A (2022). The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease. , 1348 - 1353. 10.5455/annalsmedres.2022.04.118
Chicago	ATICI BUĞRAHAN,Uyumlu Ayşe Burçin,ÇETİN Aslı The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease. (2022): 1348 - 1353. 10.5455/annalsmedres.2022.04.118
MLA	ATICI BUĞRAHAN,Uyumlu Ayşe Burçin,ÇETİN Aslı The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease. , 2022, ss.1348 - 1353. 10.5455/annalsmedres.2022.04.118
AMA	ATICI B,Uyumlu A,ÇETİN A The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease. . 2022; 1348 - 1353. 10.5455/annalsmedres.2022.04.118
Vancouver	ATICI B,Uyumlu A,ÇETİN A The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease. . 2022; 1348 - 1353. 10.5455/annalsmedres.2022.04.118
IEEE	ATICI B,Uyumlu A,ÇETİN A "The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease." , ss.1348 - 1353, 2022. 10.5455/annalsmedres.2022.04.118
ISNAD	ATICI, BUĞRAHAN vd. "The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease". (2022), 1348-1353. https://doi.org/10.5455/annalsmedres.2022.04.118

APA	ATICI B, Uyumlu A, ÇETİN A (2022). The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease. Annals of Medical Research, 29(12), 1348 - 1353. 10.5455/annalsmedres.2022.04.118
Chicago	ATICI BUĞRAHAN,Uyumlu Ayşe Burçin,ÇETİN Aslı The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease. Annals of Medical Research 29, no.12 (2022): 1348 - 1353. 10.5455/annalsmedres.2022.04.118
MLA	ATICI BUĞRAHAN,Uyumlu Ayşe Burçin,ÇETİN Aslı The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease. Annals of Medical Research, vol.29, no.12, 2022, ss.1348 - 1353. 10.5455/annalsmedres.2022.04.118
AMA	ATICI B,Uyumlu A,ÇETİN A The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease. Annals of Medical Research. 2022; 29(12): 1348 - 1353. 10.5455/annalsmedres.2022.04.118
Vancouver	ATICI B,Uyumlu A,ÇETİN A The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease. Annals of Medical Research. 2022; 29(12): 1348 - 1353. 10.5455/annalsmedres.2022.04.118
IEEE	ATICI B,Uyumlu A,ÇETİN A "The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease." Annals of Medical Research, 29, ss.1348 - 1353, 2022. 10.5455/annalsmedres.2022.04.118
ISNAD	ATICI, BUĞRAHAN vd. "The role of Nrf2/SIRT1 pathway in the hepatoprotective effect of PEITC against HFD/STZ-induced diabetic liver disease". Annals of Medical Research 29/12 (2022), 1348-1353. https://doi.org/10.5455/annalsmedres.2022.04.118