Yıl: 2023 Cilt: 30 Sayı: 4 Sayfa Aralığı: 481 - 485 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2023.02.043 İndeks Tarihi: 03-05-2023

Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning

Öz:
Aim: To classify angina pectoris (AP) in women by applying the Bagged CART approach, which is one of the machine learning (ML) methods, to the open-access AP dataset. Another aim is to reveal the risk factors associated with AP in women through modeling. Materials and Methods: In the current study, modeling was done with the Bagged CART technique utilizing an open-access data set containing the factors associated with AP. Model results were assessed with accuracy (ACC), sensitivity (Sen), balanced accu racy (BACC), positive predictive value (PPV), specificity (Spe), negative predictive value (NPV), and F1-score performance criteria. In addition, a 5-fold cross-validation approach was applied in the modeling phase. Finally, variable importance was derived with model ing. Results: ACC, BACC, Sen, Spe, PPV, NPV, and F1-score from Bagged CART modeling were 98.5%, 98.5%, 99.0%, 98.0%, 98.0%, 99.0%, and 98.5%, respectively. Depending on the variable importance values calculated for the input variables investigated in the current study, age, family history of myocardial infarction: yes, the average number of cigarettes smoked per day smoking status: current, family history of angina: yes, hypertensive condition: moderate, smoking status: ex, hypertensive condition: mild, family history of stroke: yes, whether the woman has diabetes: yes were obtained as the most important variables associated with AP. Conclusion: With the ML model used, the AP dataset was classified successfully, and the associated risk factors were revealed. ML models can be used as clinical decision support systems for early diagnosis and treatment.
Anahtar Kelime: Angina pectoris Machine learning Bagged CART Modeling

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Mitka M. Heart disease a global health threat. Jama. 2004;291(21):2533-.
  • 2. Şahin B, İlgün G. Risk factors of deaths related to cardiovascular diseases in World Health Organization (WHO) member coun tries. Health & Social Care in the Community. 2022;30(1):73-80.
  • 3. Crea F, Camici PG, De Caterina R, Lanza GA. Chronic is chaemic heart disease. In: Camm AJ, Luescher TF, Serruys PW, Eds. The ESC Textbook of Cardiovascular Medicine, Blackwell Publishing Ltd., Oxford, 2006; 391-424.
  • 4. Kim HW, Klem I, Kim RJ. Detection of myocardial ischemia by stress perfusion cardiovascular magnetic resonance. Magnetic resonance imaging clinics of North America. 2007;15(4):527-40.
  • 5. Diamond GA. A clinically relevant classification of chest discom fort. Journal of the American College of Cardiology. 1983;1(2 Part 1):574-5.
  • 6. Timmis AD, Feder G, Hemingway H. Prognosis of stable angina pectoris: why we need larger population studies with higher end point resolution. Heart. 2007;93(7):786-91.
  • 7. Möller-Leimkühler AM. Gender differences in cardiovascular dis ease and comorbid depression. Dialogues in clinical neuroscience. 2022;71-83.
  • 8. Wenger NK. Angina in women. Current cardiology reports. 2010;12(4):307-14.
  • 9. Thabtah F. Machine learning in autistic spectrum disorder be havioral research: A review and ways forward. Informatics for Health and Social Care. 2019;44(3):278-97.
  • 10. Muhammad L, Algehyne EA, Usman SS. Predictive supervised machine learning models for diabetes mellitus. SN Computer Science. 2020;1(5):1-10.
  • 11. Muhammad L, Al-Shourbaji I, Haruna AA, Mohammed IA, Ah mad A, Jibrin MB. Machine learning predictive models for coro nary artery disease. SN Computer Science. 2021;2(5):1-11.
  • 12. Hamze-Ziabari S, Bakhshpoori T. Improving the prediction of ground motion parameters based on an efficient bagging ensem ble model of M5´ and CART algorithms. Applied Soft Comput ing. 2018;68:147-61.
  • 13. Deng H, Diao Y, Wu W, Zhang J, Ma M, Zhong X. A high-speed D-CART online fault diagnosis algorithm for rotor systems. Ap plied Intelligence. 2020;50(1):29-41.
  • 14. Choubin B, Abdolshahnejad M, Moradi E, Querol X, Mosavi A, Shamshirband S, et al. Spatial hazard assessment of the PM10 using machine learning models in Barcelona, Spain. Science of The Total Environment. 2020;701:134474.
  • 15. Breiman L, Friedman JH, Olshen RA, Stone CJ. Classification and regression trees: Chapman & Hall; 1984;358.
  • 16. Timofeev R. Classification and regression trees (CART) theory and applications. Humboldt University, Berlin. 2004;54.
  • 17. Murphree DH, Arabmakki E, Ngufor C, Storlie CB, McCoy RG. Stacked classifiers for individualized prediction of glycemic con trol following initiation of metformin therapy in type 2 diabetes. Computers in biology and medicine. 2018;103:109-15.
  • 18. Duan H, Deng Z, Deng F, Wang D. Assessment of groundwater potential based on multicriteria decision making model and de cision tree algorithms. Mathematical Problems in Engineering. 2016;2016.
  • 19. Rosamond W, Flegal K, Friday G, Furie K, Go A, Green lund K, et al. Heart disease and stroke statistics—2007 up date: a report from the American Heart Association Statis tics Committee and Stroke Statistics Subcommittee. Circulation. 2007;115(5):69-171.
  • 20. Allender S, Scarborough P, Peto V, Rayner M, Leal J, Luengo Fernandez R., & Gray A. European cardiovascular disease statis tics. European Heart Network. 2008;3:11-35.
  • 21. Hemingway H, Langenberg C, Damant J, Frost C, Pyörälä K, Barrett-Connor E. Prevalence of angina in women versus men: a systematic review and meta-analysis of international variations across 31 countries. Circulation. 2008;117(12):1526-36.
  • 22. Bairey Merz CN, Shaw LJ, Reis SE, Bittner V, Kelsey SF, Olson M, et al. Insights from the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study: Part II: gender differences in presentation, diagnosis, and outcome with regard to gender based pathophysiology of atherosclerosis and macrovascular and microvascular coronary disease. Journal of the American College of Cardiology. 2006;47(3S):21-9.
  • 23. Zuchi C, Tritto I, Ambrosio G. Angina pectoris in women: fo cus on microvascular disease. International journal of cardiology. 2013;163(2):132-40.
  • 24. Absar N, Das EK, Shoma SN, Khandaker MU, Miraz MH, Faruque MRI, Tamam N, Sulieman A, Pathan RK. The Effi cacy of Machine-Learning-Supported Smart System for Heart Disease Prediction. Healthcare (Basel). 2022;10(6):1137.
  • 25. Mohan S, Thirumalai C, Srivastava G. Effective heart disease prediction using hybrid machine learning techniques. IEEE ac cess. 2019;7:81542-54.
  • 26. Xue X, Liu Y, Yang M, Wang S, Huang M, Gao S, Xu Y, Gao S, Li L, Yu C. Effect of hypercholesterolemia alone or combined with hypertension on the degree of coronary artery stenosis in patients with coronary heart disease angina pectoris: A medi cal records based retrospective study protocol. Medicine (Balti more). 2020;99(38): e22225.
  • 27. Xu M, Li H-W, Chen H, Guo C-Y. Sex and age differences in patients with unstable angina pectoris: a single-center retro spective study. The American Journal of the Medical Sciences. 2020;360(3):268-78.
  • 28. Merry AH, Boer J, Schouten LJ, Feskens EJ, Verschuren W, Gorgels AP, et al. Smoking, alcohol consumption, physical activ ity, and family history and the risks of acute myocardial infarc tion and unstable angina pectoris: a prospective cohort study. BMC cardiovascular disorders. 2011;11(1):1-14.
  • 29. Çiçek İB, Küçükakçali Z, Güldoğan E. Comparison Of Differ ent Decision Tree Models In Classification Of Angina Pectoris Disease. The Journal Of Cognitive Systems.5(2):74-7.
APA Ozhan O, BALIKCI CICEK I, KÜÇÜKAKÇALI Z (2023). Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning. , 481 - 485. 10.5455/annalsmedres.2023.02.043
Chicago Ozhan Onural,BALIKCI CICEK IPEK,KÜÇÜKAKÇALI ZEYNEP Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning. (2023): 481 - 485. 10.5455/annalsmedres.2023.02.043
MLA Ozhan Onural,BALIKCI CICEK IPEK,KÜÇÜKAKÇALI ZEYNEP Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning. , 2023, ss.481 - 485. 10.5455/annalsmedres.2023.02.043
AMA Ozhan O,BALIKCI CICEK I,KÜÇÜKAKÇALI Z Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning. . 2023; 481 - 485. 10.5455/annalsmedres.2023.02.043
Vancouver Ozhan O,BALIKCI CICEK I,KÜÇÜKAKÇALI Z Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning. . 2023; 481 - 485. 10.5455/annalsmedres.2023.02.043
IEEE Ozhan O,BALIKCI CICEK I,KÜÇÜKAKÇALI Z "Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning." , ss.481 - 485, 2023. 10.5455/annalsmedres.2023.02.043
ISNAD Ozhan, Onural vd. "Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning". (2023), 481-485. https://doi.org/10.5455/annalsmedres.2023.02.043
APA Ozhan O, BALIKCI CICEK I, KÜÇÜKAKÇALI Z (2023). Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning. Annals of Medical Research, 30(4), 481 - 485. 10.5455/annalsmedres.2023.02.043
Chicago Ozhan Onural,BALIKCI CICEK IPEK,KÜÇÜKAKÇALI ZEYNEP Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning. Annals of Medical Research 30, no.4 (2023): 481 - 485. 10.5455/annalsmedres.2023.02.043
MLA Ozhan Onural,BALIKCI CICEK IPEK,KÜÇÜKAKÇALI ZEYNEP Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning. Annals of Medical Research, vol.30, no.4, 2023, ss.481 - 485. 10.5455/annalsmedres.2023.02.043
AMA Ozhan O,BALIKCI CICEK I,KÜÇÜKAKÇALI Z Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning. Annals of Medical Research. 2023; 30(4): 481 - 485. 10.5455/annalsmedres.2023.02.043
Vancouver Ozhan O,BALIKCI CICEK I,KÜÇÜKAKÇALI Z Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning. Annals of Medical Research. 2023; 30(4): 481 - 485. 10.5455/annalsmedres.2023.02.043
IEEE Ozhan O,BALIKCI CICEK I,KÜÇÜKAKÇALI Z "Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning." Annals of Medical Research, 30, ss.481 - 485, 2023. 10.5455/annalsmedres.2023.02.043
ISNAD Ozhan, Onural vd. "Analyzing and detecting risk factors for the diagnosis of angina pectoris with machine learning". Annals of Medical Research 30/4 (2023), 481-485. https://doi.org/10.5455/annalsmedres.2023.02.043