TY  - JOUR
TI  - Expression and prognostic value of ING3 in advanced laryngeal squamous cell carcinoma
AB  - Objectives: Laryngeal squamous cell carcinomas (LSCC) is one of the most common aggressive neoplasms of the head and neck region. There is a significant need for identification of successful and accurate prognostic markers to better estimate the clinical outcomes for LSCC patients. In this study, we aimed at analyzing the differential expressions of inhibitor growth (ING) family members and to evaluate the prognostic values of deregulated ING genes in LSCC.  Methods: We investigated the relative expressions of ING genes in laryngeal tumor-normal tissue pairs in the mRNA level using quantitative real-time polymerase chain reaction and relative expression of ING3 in the protein level using Western Blot analysis.  Results: The rate of genetic alterations of ING3 was relatively higher in head and neck cancer including LSCC. ING3 expression was significantly upregulated in LSCC tissue samples in both mRNA and protein level. Higher expression of ING3 was also correlated with poor disease-free survival of patients with head and neck cancer.  Conclusions: Our findings assigned an oncogenic feature for ING3 in laryngeal cancer with a significant upregulation detected in advanced cases and suggested a vital prognostic potential for ING3.
AU  - Kuşdemir, Gülnur
AU  - BARLAK, Neslisah
AU  - Şahin, Abdulkadir
AU  - GÜNDOĞDU, BETÜL
AU  - Karatas, Omer
AU  - Tatar, Arzu
AU  - GÜMÜŞ, Rasim
DO  - 10.18621/eurj.1108404
PY  - 2023
JO  - The European Research Journal
VL  - 9
IS  - 3
SN  - 2149-3189
SP  - 517
EP  - 528
DB  - TRDizin
UR  - http://search/yayin/detay/1165317
ER  -