Yıl: 2023 Cilt: 9 Sayı: 3 Sayfa Aralığı: 529 - 535 Metin Dili: İngilizce DOI: 10.18621/eurj.1149697 İndeks Tarihi: 03-05-2023

Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients

Öz:
Objectives: Breast cancer is the second leading cause of cancer deaths among women. Therefore, there is a need for new approaches that increase the success of treatment in breast cancer. Cancer stem cells (CSCs) are associated with treatment resistance and metastasis, which are important problems in cancer treatment including breast tumors. In this study, the Hematopoietic- and neurologic-expressed sequence 1-like (HN1L), also known as Jupiter microtubule associated homolog 2 (JPT2) protein levels which is involved in the self-renewal of CSCs were evaluated in common and rare breast tumor types. Methods: In this context, HN1L protein levels were measured from plasma of 17 patients and from tumor and normal tissues of 9 patients by enzyme linked immunosorbent assay method. Results: Mean HN1L levels were measured as 1.63 ± 0.88 ng/mL in plasma samples, 2.18 ± 0.75 ng/mL in tumor tissue samples and 2.71 ± 0.88 ng/mL in normal tissue samples. A significant difference was observed between mean HN1L levels in plasma and normal tissue (p < 0.05). Correlation of HN1L protein levels with clinicopathological characteristics were analyzed. Accordingly, HN1L levels were positively correlated with tumor size and invasion status (r=0.425; p < 0.05 and r=0.449; p < 0.05, respectively). Conclusions: We believe that the importance of HN1L in management of breast cancers will be demonstrated more thoroughly when further studies are conducted with increased number of patients.
Anahtar Kelime: HN1L JPT2 breast cancer cancer stem cell

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Ertürk E, Sarimahmut M, Gökgöz M, Tolunay Ş (2023). Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients. , 529 - 535. 10.18621/eurj.1149697
Chicago Ertürk Elif,Sarimahmut Mehmet,Gökgöz Mustafa Şehsuvar,Tolunay Şahsine Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients. (2023): 529 - 535. 10.18621/eurj.1149697
MLA Ertürk Elif,Sarimahmut Mehmet,Gökgöz Mustafa Şehsuvar,Tolunay Şahsine Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients. , 2023, ss.529 - 535. 10.18621/eurj.1149697
AMA Ertürk E,Sarimahmut M,Gökgöz M,Tolunay Ş Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients. . 2023; 529 - 535. 10.18621/eurj.1149697
Vancouver Ertürk E,Sarimahmut M,Gökgöz M,Tolunay Ş Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients. . 2023; 529 - 535. 10.18621/eurj.1149697
IEEE Ertürk E,Sarimahmut M,Gökgöz M,Tolunay Ş "Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients." , ss.529 - 535, 2023. 10.18621/eurj.1149697
ISNAD Ertürk, Elif vd. "Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients". (2023), 529-535. https://doi.org/10.18621/eurj.1149697
APA Ertürk E, Sarimahmut M, Gökgöz M, Tolunay Ş (2023). Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients. The European Research Journal, 9(3), 529 - 535. 10.18621/eurj.1149697
Chicago Ertürk Elif,Sarimahmut Mehmet,Gökgöz Mustafa Şehsuvar,Tolunay Şahsine Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients. The European Research Journal 9, no.3 (2023): 529 - 535. 10.18621/eurj.1149697
MLA Ertürk Elif,Sarimahmut Mehmet,Gökgöz Mustafa Şehsuvar,Tolunay Şahsine Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients. The European Research Journal, vol.9, no.3, 2023, ss.529 - 535. 10.18621/eurj.1149697
AMA Ertürk E,Sarimahmut M,Gökgöz M,Tolunay Ş Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients. The European Research Journal. 2023; 9(3): 529 - 535. 10.18621/eurj.1149697
Vancouver Ertürk E,Sarimahmut M,Gökgöz M,Tolunay Ş Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients. The European Research Journal. 2023; 9(3): 529 - 535. 10.18621/eurj.1149697
IEEE Ertürk E,Sarimahmut M,Gökgöz M,Tolunay Ş "Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients." The European Research Journal, 9, ss.529 - 535, 2023. 10.18621/eurj.1149697
ISNAD Ertürk, Elif vd. "Evaluation of hematopoietic- and neurologic-expressed sequence 1-like (HN1L) protein levels in tissue and plasma of breast cancer patients". The European Research Journal 9/3 (2023), 529-535. https://doi.org/10.18621/eurj.1149697