Purpose: The purpose of the study is to analyze the neurological manifestations and to determine the association between these symptoms and mortality in hospitalized patients with coronavirus disease 2019 (COVID 19). Materials and Methods: Five hundred and forty seven hospitalized patients with positive reverse transcriptase polymerase chain reaction tests for severe acute respiratory syndrome coronavirus in a nasopharyngeal swab were included in this study. The demographic features, laboratory data, and radiologic imaging, neurological symptoms of hospitalized patients with COVID 19 were collected. Results: Of 547 hospitalized COVID 19 patients, the median age was 61 (range 18–93), 61.4% were male. Three hundred and forty seven (63.4%) patients had a severe infection and 200 (36.6%) patients had a mild infection. Eighty eight patients (16.1%) died during hospitalization. One hundred and fifty four (28.2%) patients had at least one neurological symptom. Thirty five (6.4%) patients manifested with only neurological symptoms at hospital admission. The most frequent neurological symptoms were headache (15.2%), taste and smell disorders (9.1%), and myalgia (6.6%). The other initial neurological manifestations were acute cerebral ischemic stroke, impaired consciousness, epileptic seizure, and posterior reversible encephalopathy. The late onset neurological complications were autoimmune encephalitis and Guillain Barre syndrome. The neurological manifestation was linked to the severity of disease (P = 0.005) but not correlated with mortality (P = 0.137). Conclusion: Neurological symptoms were frequent in COVID 19 patients. The neurological symptoms can be the initial symptoms or can be late onset complications of COVID 19.