TY  - JOUR
TI  - The effect of subclinical hypothyroidism on ovarian  volume in prepubertal girls
AB  - OBJECTIVE: Enlargement and cystic changes in ovaries of patients with long-standing overt hypothyroidism have been  described in numerous case reports. However, there are limited data about the effect of subclinical hypothyroidism (SH) on  ovarian volume. The aim of the study is to evaluate the relationship between serum thyroid stimulating hormone (TSH) level  and ovarian volume in prepubertal girls with SH. METHODS: Patients who were aged between 6 and 10 years and diagnosed with SH and age-matched healthy euthyroid  controls were enrolled in the study. All subjects were prepubertal. RESULTS: Thirty-five children with SH (mean age; 7.6±1.0 years) and 50 euthyroid healthy girls (mean age; 7.7±1.2 years)  were enrolled in the study. TSH and LH levels and both ovarian volumes were significantly higher in SH group than controls  (p<0.05). In addition, TSH was positively correlated with ovarian volumes and LH in patients with SH (p<0.05). CONCLUSION: The results of this study showed that ovarian volumes of prepubertal girls with SH were significantly greater  than those with normal thyroid function. Although ovarian enlargement and cyst formation is well recognized in long-standing  overt hypothyroidism, it has been shown for the 1st time in patients with SH.
AU  - karakuş sert, tuba
AU  - kirankaya, aysegul
AU  - Yiğit, Özgül
AU  - Ekinci, Deniz
AU  - Kılınç, Suna
DO  - 10.14744/nci.2021.78300
PY  - 2023
JO  - İstanbul Kuzey Klinikleri
VL  - 10
IS  - 1
SN  - 2148-4902
SP  - 48
EP  - 52
DB  - TRDizin
UR  - http://search/yayin/detay/1165408
ER  -