TY  - JOUR
TI  - Relationship of HLA-B alleles on susceptibility to and  protection from HIV infection in Turkish population
AB  - OBJECTIVE: Many human leukocyte antigen (HLA)-B alleles are associated with an increased risk of Acquired Immune Defi ciency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) progression; however, their distribution varies among dif ferent racial/ethnic groups. Abacavir used in the treatment of AIDS significantly increases the risk of hypersensitivity reactions  in patients with HLA-B*57:01. The aim of this study was to determine the distribution of HIV-associated HLA-B subgroups  (high and low resolution) and HLA-B*57:01 associated with Abacavir sensitivity in Turkiye. METHODS: This retrospective case-control study consisted of 416 (F/M:111/305) HIV positive patients and 416 (F/M:111/305)  healthy controls. HLA-B alleles were identified using Luminex based low-resolution method and further subgrouped by se quence-based high-resolution typing. RESULTS: Our data showed that in patients with HIV-1 infection, HLA-B*15, *35, and *51 allele frequencies were high er, while the HLA-B*07, *14 and *55 allele frequencies were lower as compared to the controls. It was determined that  HLA-B*15:01, *35:01, *35:08, and *51:01 alleles frequencies were higher in the patients with HIV-1 infection compared to  the controls as HLA-B*07:02, *14:01, *44:01, and *55:01 allele frequencies were detected low. HLA-B*57:01 allele positivity,  which is important in Abacavir hypersensitivity, was lower than controls, and this difference was not statistically significant. CONCLUSION: Our results suggest that, HLA-B*07, *14, and *55 alleles and HLA-B*07:02, *14:01, *44:01, and *55:01  subgroups might have a protective effect, while HLA-B*15, *35, and *51 alleles and HLA-B*15:01, *35:01, *35:08, and  *51:01 subgroups might play a role in susceptibility to HIV-1 infection.
AU  - İNAN, DİLARA
AU  - KILINÇ, YAHYA
AU  - Arslan, Habibe Sema
AU  - UÇAR, Fahri
AU  - Sayın EKİNCİ, Nurten
AU  - boylubay, özaydın
AU  - Darbas, Sule
AU  - KOKSOY, SADI
AU  - Mutlu, Esvet
AU  - YUCEL, Burcu
DO  - 10.14744/nci.2021.00018
PY  - 2023
JO  - İstanbul Kuzey Klinikleri
VL  - 10
IS  - 1
SN  - 2148-4902
SP  - 67
EP  - 73
DB  - TRDizin
UR  - http://search/yayin/detay/1165484
ER  -