Yıl: 2022 Cilt: 60 Sayı: 1 Sayfa Aralığı: 9 - 15 Metin Dili: İngilizce DOI: 10.4274/tao.2022.2021-6-11 İndeks Tarihi: 04-05-2023

Management of Basal Cell Carcinomas: Clinical Experience

Öz:
Objective: Basal cell carcinomas (BCC) mostly originate from the head and neck region. Main goal in BCC treatment is to achieve both aesthetic and functional results while observing the principles of tumor surgery. We report our experience regarding the clinical, histopathological features and surgical treatment results of head and neck basal cell carcinomas in the light of the literature. Methods: Files of patients with head and neck BCCs treated surgically in two university hospitals were retrospectively analyzed. Sociodemographic variables, location and size of tumor, pathological subtype, recurrence ratio, complications and technique of reconstruction were evaluated. Results: We analyzed 119 tumoral lesions in 105 patients of whom 55 (52.4%) were male and 50 (47.6%) were female. Their mean age was 67.3±12 years. The nasal region was the most common location area (n=42, 35.3%). Mean tumor size was 12.6 mm and tumor size range was 2–85 mm. The most commonly used reconstruction techniques were flap surgery, followed by primary closure, and skin grafts. Conclusion: It is important to remove the tumor with a clear surgical margin at least 4 mm and evaluate the five surgical margins with frozen sections intraoperatively. Operations are often performed under local anesthesia and are well tolerated by patients. The most common flaps used in the reconstruction are not only easy to learn but also sufficient in most cases. Skin grafts are good choices in defects located in the cavum concha and the external meatus.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Mantese SAO, Berbert ALCV, Gomides MDA, Rocha A. Basal cell carcinoma - analysis of 300 cases observed in Uberlândia-MG, Brazil. An Bras Dermatol 2006; 81: 136-42. [Crossref ]
  • 2. Kuijpers DI, Thissen MR, Neumann MH. Basal cell carcinoma: treatment options and prognosis, a scientific approach to a common malignancy. Am J Clin Dermatol 2002; 3: 247-59. [Crossref ]
  • 3. Chinem VP, Miot HA. Epidemiology of basal cell carcinoma. An Bras Dermatol 2011; 86: 292-305. [Crossref ]
  • 4. Altamura D, Menzies SW, Argenziano G, Zalaudek I, Soyer HP, Sera F, et al. Dermatoscopy of basal cell carcinoma: morphologic variability of global and local features and accuracy of diagnosis. J Am Acad Dermatol 2010; 62: 67-75. [Crossref ]
  • 5. Eskiizmir G, Cingi C. Nonmelanoma skin cancer of the head and neck: current diagnosis and treatment. Facial Plast Surg Clin North Am 2012; 20: 415-7. [Crossref ]
  • 6. Marzuka AG, Book SE. Basal cell carcinoma: pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management. Yale J Biol Med 2015; 88: 167-79. [Crossref ]
  • 7. Kauvar AN, Cronin Jr T, Roenigk R, Hruza G, Bennett R, American Society for Dermatologic Surgery. Consensus for nonmelanoma skin cancer treatment: basal cell carcinoma, including a cost analysis of treatment methods. Dermatol Surg 2015; 41: 550-71. [Crossref ]
  • 8. Garcovich S, Colloca G, Sollena P, Andrea B, Balducci L, Cho WC, et al. Skin cancer epidemics in the elderly as an emerging issue in geriatric oncology. Aging Dis 2017; 8: 643-61. [Crossref ]
  • 9. Bichakjian CK, Olencki T, Aasi SZ, Alam M, Andersen JS, Berg D, et al. Basal cell skin cancer, version 1.2016, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 2016; 14: 574-97. [Crossref ]
  • 10. Wolf DJ, Zitelli JA. Surgical margins for basal cell carcinoma. Arch Dermatol 1987; 123: 340-4. [Crossref ]
  • 11. Bernardini N, Skroza N, Zuber S, Tolino E, Balduzzi V, Mambrin A, et al. Face and scalp basal cell carcinoma treatment: a review of the literature. Acta Dermatovenerol Croat 2019; 27: 22-7. [Crossref ]
  • 12. Miller DL, Weinstock MA. Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol 1994; 30: 774-8. [Crossref ]
  • 13. Cameron MC, Lee E, Hibler BP, Barker CA, Mori S, Cordova M, et al. Basal cell carcinoma: epidemiology; pathophysiology; clinical and histological subtypes; and disease associations. J Am Acad Dermatol 2019; 80: 303-17. [Crossref ]
  • 14. Diffey BL, Tate TJ, Davis A. Solar dosimetry of the face: the relationship of natural ultraviolet radiation exposure to basal cell carcinoma localisation. Phys Med Biol 1979; 24: 931-9. [Crossref ]
  • 15. Kang KW, Lee DL, Shin HK, Jung GY, Lee JH, Jeon MS. A retrospective clinical view of basal cell carcinoma and squamous cell carcinoma in the head and neck region: a single institution's experience of 247 cases over 19 years. Arch Craniofac Surg 2016; 17: 56-62. [Crossref ]
  • 16. Bertozzi N, Simonacci F, Greco MP, Grignaffini E, Raposio E. Single center evidence for the treatment of basal cell carcinoma of the head and neck. Acta Biomed 2019; 90: 77-82. [Crossref ]
  • 17. Dalal AJ, Ingham J, Collard B, Merrick G. Review of outcomes of 500 consecutive cases of non-melanoma skin cancer of the head and neck managed in an oral and maxillofacial surgical unit in a District General Hospital. Br J Oral Maxillofac Surg 2018; 56: 805-9. [Crossref ]
  • 18. Derebaşınlıoğlu H. Distribution of skin cancers of the head and neck according to anatomical subunit. Eur Arch Otorhinolaryngol 2022; 279: 1461-6. [Crossref ]
  • 19. Trakatelli M, Morton C, Nagore E, Ulrich C, Del Marmol V, Peris K, et al. Update of the European guidelines for basal cell carcinoma management. Eur J Dermatol 2014; 24: 312-29. [Crossref ]
  • 20. Kjerkegaard UK, Stolle LB. Incomplete excision of non-melanoma skin cancer of the head and neck: can we predict failure? Eur J Plast Surg 2014; 37: 141-6. [Crossref ]
  • 21. Ceilley RI, Del Rosso JQ. Current modalities and new advances in the treatment of basal cell carcinoma. Int J Dermatol 2006; 45: 489-98. [Crossref ]
  • 22. Breuninger H, Dietz K. Prediction of subclinical tumor infiltration in basal cell carcinoma. J Dermatol Surg Oncol 1991; 17: 574-8. [Crossref ]
  • 23. Kansara S, Bell D, Weber R. Surgical management of non melanoma skin cancer of the head and neck. Oral Oncol 2020; 100: 104485. [Crossref ]
  • 24. Neumann H. Approach to the oncological patient. Oncological dermatosurgery Maastricht: University of Maastricht. 1996.p.135- 46. [Crossref ]
  • 25. Mahadevan K, Sruthi S, Sridevi S, Vivek R. Fourth dimension in reconstruction of defects following excision of basal cell carcinoma of head and neck. J Cutan Aesthet Surg 2018; 11: 110-9. [Crossref ]
  • 26. Rowe DE. Comparison of treatment modalities for basal cell carcinoma. Clin Dermatol 1995; 13: 617-20. [Crossref ]
APA Kara İ, Vural A, unlu m, San F, Göçer G, YILDIZ M (2022). Management of Basal Cell Carcinomas: Clinical Experience. , 9 - 15. 10.4274/tao.2022.2021-6-11
Chicago Kara İrfan,Vural Alperen,unlu metin,San Furkan,Göçer Gülten Benan,YILDIZ Muhammed Gazi Management of Basal Cell Carcinomas: Clinical Experience. (2022): 9 - 15. 10.4274/tao.2022.2021-6-11
MLA Kara İrfan,Vural Alperen,unlu metin,San Furkan,Göçer Gülten Benan,YILDIZ Muhammed Gazi Management of Basal Cell Carcinomas: Clinical Experience. , 2022, ss.9 - 15. 10.4274/tao.2022.2021-6-11
AMA Kara İ,Vural A,unlu m,San F,Göçer G,YILDIZ M Management of Basal Cell Carcinomas: Clinical Experience. . 2022; 9 - 15. 10.4274/tao.2022.2021-6-11
Vancouver Kara İ,Vural A,unlu m,San F,Göçer G,YILDIZ M Management of Basal Cell Carcinomas: Clinical Experience. . 2022; 9 - 15. 10.4274/tao.2022.2021-6-11
IEEE Kara İ,Vural A,unlu m,San F,Göçer G,YILDIZ M "Management of Basal Cell Carcinomas: Clinical Experience." , ss.9 - 15, 2022. 10.4274/tao.2022.2021-6-11
ISNAD Kara, İrfan vd. "Management of Basal Cell Carcinomas: Clinical Experience". (2022), 9-15. https://doi.org/10.4274/tao.2022.2021-6-11
APA Kara İ, Vural A, unlu m, San F, Göçer G, YILDIZ M (2022). Management of Basal Cell Carcinomas: Clinical Experience. Turkish archives of otorhinolaryngology , 60(1), 9 - 15. 10.4274/tao.2022.2021-6-11
Chicago Kara İrfan,Vural Alperen,unlu metin,San Furkan,Göçer Gülten Benan,YILDIZ Muhammed Gazi Management of Basal Cell Carcinomas: Clinical Experience. Turkish archives of otorhinolaryngology 60, no.1 (2022): 9 - 15. 10.4274/tao.2022.2021-6-11
MLA Kara İrfan,Vural Alperen,unlu metin,San Furkan,Göçer Gülten Benan,YILDIZ Muhammed Gazi Management of Basal Cell Carcinomas: Clinical Experience. Turkish archives of otorhinolaryngology , vol.60, no.1, 2022, ss.9 - 15. 10.4274/tao.2022.2021-6-11
AMA Kara İ,Vural A,unlu m,San F,Göçer G,YILDIZ M Management of Basal Cell Carcinomas: Clinical Experience. Turkish archives of otorhinolaryngology . 2022; 60(1): 9 - 15. 10.4274/tao.2022.2021-6-11
Vancouver Kara İ,Vural A,unlu m,San F,Göçer G,YILDIZ M Management of Basal Cell Carcinomas: Clinical Experience. Turkish archives of otorhinolaryngology . 2022; 60(1): 9 - 15. 10.4274/tao.2022.2021-6-11
IEEE Kara İ,Vural A,unlu m,San F,Göçer G,YILDIZ M "Management of Basal Cell Carcinomas: Clinical Experience." Turkish archives of otorhinolaryngology , 60, ss.9 - 15, 2022. 10.4274/tao.2022.2021-6-11
ISNAD Kara, İrfan vd. "Management of Basal Cell Carcinomas: Clinical Experience". Turkish archives of otorhinolaryngology 60/1 (2022), 9-15. https://doi.org/10.4274/tao.2022.2021-6-11