The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm
Yıl: 2023 Cilt: 30 Sayı: 1 Sayfa Aralığı: 66 - 71 Metin Dili: İngilizce DOI: 10.5505/vtd.2023.30676 İndeks Tarihi: 04-05-2023
The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm
Öz: Introduction: Ascending aorta aneurysm is a serious condition with an undetermined pathophysiology. Trace elements are essential for the effective performance of the body's multiple systems, including the immune system and relevant information to inflammation and infections. Since inflammation may contribute to the etiology of ascending aortic aneurysm, we investigated whether trace element alterations associated with inflammation occur in blood and tissue samples over the course of the condition. Materials and Methods: We compared 32 individuals who underwent coronary artery bypass grafting and 23 patients who underwent surgery for an ascending aortic aneurysm. During surgery, samples of the ascending aorta's anterior portion removed from the aortic wall. The tissue's iron (Fe), copper (Cu), and zinc (Zn) levels measured. Results: There were no statisticaly significant differences between the groups in the Zn averages of the cases divided by groups. Individual Cu mean values of the study group were statistically significantly lower than those of the control group. The mean Fe levels of the participants in the study group identified to be statistically substantially higher than those of the control group. Conclusion: In this study, we aimed to find out more about the relationship between changes in the levels of trace elements in the tissue of the ascending aorta and aneurysm development. We believe that changes in trace element levels may involve a role in the progression of aortic aneurysms.
Anahtar Kelime: Asendan Aort Anevrizma Gelişiminde Eser Elementlerin Etkisi
Öz: Amaç: Asendan aort anevrizması patofizyolojisi bilinmeyen ciddi bir durumdur. Eser elementler, bağışıklık sistemi, iltihaplanma ve enfeksiyonlarla ilgili bilgiler dahil olmak üzere vücudun çoklu sistemlerinin etkili performansı için gereklidir. İnflamasyon asendan aort anevrizmasının etiyolojisine katkıda bulunabileceğinden, kan ve doku örneklerinde inflamasyonla ilişkili eser element değişikliklerinin oluşup oluşmadığını araştırdık. Gereç ve Yöntem: Bu çalışmada koroner arter baypas greftlemesi yapılan 32 hasta ile asendan aort anevrizması nedeniyle ameliyat edilen 23 hastayı karşılaştırdık. Asenden aort ön kısmından ameliyat esnasında doku örnekerli aldık. Dokularda demir (Fe), bakır (Cu) ve çinko (Zn) seviyeleri ölçüldü. Bulgular: Gruplar arasında Zn ortalamalarında istatistiksel olarak anlamlı fark bulunmadı. Çalışma grubunun Cu ortalama değerleri, kontrol grubununkinden istatistiksel olarak anlamlı derecede düşüktü. Çalışma grubundaki katılımcıların ortalama Fe düzeylerinin kontrol grubuna göre istatistiksel olarak önemli ölçüde yüksek olduğu belirlendi. Sonuç: Bu çalışmada,asendan aort dokusundaki eser element seviyelerindeki değişiklikler ile anevrizma gelişimi arasındaki ilişki hakkında daha fazla bilgi edinmeyi amaçladık. Eser element seviyelerindeki değişikliklerin aort anevrizmalarının ilerlemesinde rol oynayabileceğine inanıyoruz.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, et al. ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur Heart J 2014; 35:2873-2926.
- 2. Hiratzka LF, Bakris GL, Beckman JA, Bersin RM, Carr VF, Casey DE Jr, et al. ACCF/AHA/AATS/ ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Circulation 2010; 12: e266–e369.
- 3. Evangelista A, Isselbacher EM, Bossone E, Gleason T, Eusanio M, Sechtem U, et al. Insights from the International Registry of Acute Aortic Dissection: a 20-year experience of collaborative clinical research. Circulation 2018; 137:1846-1860.
- 4. Choinski K, Sanon O, Tadros R, Koleilat I, Phair J. Review of Malpractice Lawsuits in the Diagnosis and Management of Aortic Aneurysms and Aortic Dissections. Vasc Endovascular Surg 2022; 56:33-39.
- 5. Olsson C, Thelin S, Ståhle E, Ekbom A, Granath F. Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14,000 cases from 1987 to 2002. Circulation 2006; 114:2611-2618.
- 6. Goldstein SA, Evangelista A, Abbara S, Arai A, Asch FM, Badano LP, et al. Multimodality imaging of diseases of the thoracic aorta in adults: from the American Society of Echocardiography and the European Association of Cardiovascular Imaging: endorsed by the Society of Cardiovascular Computed Tomography and Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr 2015; 28:119-182.
- 7. Atchison DK, O'Connor CL, Converso- Baran K, Bergin IL, Zhang H, Wang Y, Hartman JR, Ju W, Smrcka AV, Ganesh SK, Bitzer M. Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection. Am J Physiol Heart Circ Physiol 2022; 323:1376-1387.
- 8. Pearce WH, Slaughter MS, LeMaire S, Salyapongse N, Feinglass J, Walter J, et al. Aortic diameter as a function of age, gender and body surface area. Surgery 1993; 114: 691.
- 9. Mizrak D, Feng H, Yang B. Dissecting the Heterogeneity of Human Thoracic Aortic Aneurysms Using Single-Cell Transcriptomics. Arterioscler Thromb Vasc Biol 2022 ;42:919-930.
- 10. Senapati A, Carlsson LK, Fletcher CD, Browse NL, Thompson RP. Is tissue copper deficiency associated with aortic aneurysms? Br J Surg 1985; 72:352-353.
- 11. Xu C, Zarins CK, Glagov S. Aneurysmal and occlusive atherosclerosis of the human abdominal aorta. J Vasc Surg 2001; 33:91-96.
- 12. Coady MA, Rizzo JA, Hammond GL, Kopf GS, Elefteriades JA. Surgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications. Ann Thorac Surg 1999; 67:1922-1926.
- 13. Voigt KR, Gökalp AL, Papageorgiou G, Bogers AJJC, Takkenberg JJM, Mokhles MM, Bekkers JA. Male-Female Differences in Ascending Aortic Aneurysm Surgery: 25- Year Single Center Results. Semin Thorac Cardiovasc Surg 2022; 31:1043
- 14. Mullan CW, Mori M, Bin Mahmood SU, Yousef S, Mangi AA, Elefteriades JA, Geirsson A. Incidence and characteristics of hospitalization for proximal aortic surgery for acute syndromes and for aneurysms in the USA from 2005 to 2014. Eur J Cardiothorac Surg 2020; 58:583-589.
- 15. Deepali Jain, Harry C. Dietz, Gretchen L. Oswald, Joseph J. Maleszewski, Marc K. Halushka. Causes and histopathology of ascending aortic disease in children and young adults. Cardiovasc Pathol 2011; 20:15- 25.
- 16. Loeys BL, Chen J, Neptune ER, Judge DP, Podowski M, Holm T, et al. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet 2005; 37:275–81.
- 17. Fukai T, Ushio-Fukai M, Kaplan JH. Copper transporters and copper chaperones: roles in cardiovascular physiology and disease. Am J Phys Cell Physiol 2018; 315:186-201.
- 18. Chen T, Zhang H, Zhang Y, Yang M, Wu J, Yang M, Lin J, Gao W, Tang L, Xu B, Jiang J, Chen X. Association of Circulating and Aortic Zinc and Copper Levels with Clinical Abdominal Aortic Aneurysm: A Metaanalysis. Biol Trace Elem Res 2021; 199:513- 526.
- 19. Brewer GJ. The promise of copper lowering therapy with tetrathiomolybdate in the cure of cancer and in the treatment of inflammatory disease. J Trace Elem Med Biol 2014; 28:372-378.
- 20. Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, Jondeau G, et al. Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway. J Pathol 2009; 218:131-42.
- 21. Edvinsson M, Ilbäck NG, Frisk P, Thelin S, Nyström-Rosander C. Trace Element Changes in Thoracic Aortic Dissection. Biol Trace Elem Res 2016; 169:159-163.
- 22. Xu C, Huang Z, Liu L, Luo C, Lu G, Li Q, Gao X. Zinc regulates lipid metabolism and MMPs expression in lipid disturbance rabbits. Biol Trace Elem Res 2015; 168:411- 420.
- 23. Wang X, Khalil RA. Matrix metalloproteinases, vascular remodelling, and vascular disease. Adv Pharmacol 2018; 81:241-330.
- 24. Liu J, Khalil RA. Matrix metalloproteinase inhibitors as investigational and therapeutic tools in unrestrained tissue remodeling and pathological disorders. Prog Mol Biol Transl Sci 2017; 148:355-420.
- 25. Morris DR, Biros E, Cronin O, Kuivaniemi H, Golledge J. The association of genetic variants of matrix metalloproteinases with abdominal aortic aneurysm: a systematic review and metaanalysis. Heart 2014; 100:295-302.
| APA | Gocer S, İLKELİ E, Gür A, Sunar H (2023). The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm. , 66 - 71. 10.5505/vtd.2023.30676 |
| Chicago | Gocer Sinan,İLKELİ EKİN,Gür Ali Kemal,Sunar Hasan The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm. (2023): 66 - 71. 10.5505/vtd.2023.30676 |
| MLA | Gocer Sinan,İLKELİ EKİN,Gür Ali Kemal,Sunar Hasan The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm. , 2023, ss.66 - 71. 10.5505/vtd.2023.30676 |
| AMA | Gocer S,İLKELİ E,Gür A,Sunar H The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm. . 2023; 66 - 71. 10.5505/vtd.2023.30676 |
| Vancouver | Gocer S,İLKELİ E,Gür A,Sunar H The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm. . 2023; 66 - 71. 10.5505/vtd.2023.30676 |
| IEEE | Gocer S,İLKELİ E,Gür A,Sunar H "The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm." , ss.66 - 71, 2023. 10.5505/vtd.2023.30676 |
| ISNAD | Gocer, Sinan vd. "The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm". (2023), 66-71. https://doi.org/10.5505/vtd.2023.30676 |
| APA | Gocer S, İLKELİ E, Gür A, Sunar H (2023). The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm. Van Tıp Dergisi, 30(1), 66 - 71. 10.5505/vtd.2023.30676 |
| Chicago | Gocer Sinan,İLKELİ EKİN,Gür Ali Kemal,Sunar Hasan The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm. Van Tıp Dergisi 30, no.1 (2023): 66 - 71. 10.5505/vtd.2023.30676 |
| MLA | Gocer Sinan,İLKELİ EKİN,Gür Ali Kemal,Sunar Hasan The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm. Van Tıp Dergisi, vol.30, no.1, 2023, ss.66 - 71. 10.5505/vtd.2023.30676 |
| AMA | Gocer S,İLKELİ E,Gür A,Sunar H The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm. Van Tıp Dergisi. 2023; 30(1): 66 - 71. 10.5505/vtd.2023.30676 |
| Vancouver | Gocer S,İLKELİ E,Gür A,Sunar H The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm. Van Tıp Dergisi. 2023; 30(1): 66 - 71. 10.5505/vtd.2023.30676 |
| IEEE | Gocer S,İLKELİ E,Gür A,Sunar H "The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm." Van Tıp Dergisi, 30, ss.66 - 71, 2023. 10.5505/vtd.2023.30676 |
| ISNAD | Gocer, Sinan vd. "The Effect of Trace Elements in the Development of Ascending Aorta Aneurysm". Van Tıp Dergisi 30/1 (2023), 66-71. https://doi.org/10.5505/vtd.2023.30676 |
