The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease
Yıl: 2022 Cilt: 33 Sayı: 12 Sayfa Aralığı: 1043 - 1049 Metin Dili: İngilizce DOI: 10.5152/tjg.2022.21815 İndeks Tarihi: 04-05-2023
The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease
Öz: Background: Celiac disease is associated with impaired intestinal epithelial barrier integrity. Its consequences affect the nutritional status and quality of life of patients. This study aimed to determine nutritional status, intestinal permeability, and quality of life in people with celiac disease. It was researched whether patients who are non-compliant to gluten-free diet have higher serum zonulin levels and intestinal permeability. Methods: The study was completed with 44 celiac patients. Dietary records and a questionnaire were used to evaluate patients’ compliance to the gluten-free diet. Dietary records were analyzed by using a nutrition analysis program. Anthropometric measurements were taken. Body compositions were analyzed to assess the nutritional status of patients. Blood samples were collected and then zonulin levels and total serum proteins were measured to evaluate intestinal permeability. Celiac Disease Questionnaire was used to assess the quality of life scores. Results: Patients were divided into 2 groups considering compliance to the gluten-free diet and it was found that 17 patients were compliant to the gluten-free diet, and 27 patients were non-compliant to the gluten-free diet. Serum zonulin, zonulin/total protein ratio, and intestinal permeability were higher in non-compliant to the gluten-free diet group (P < .05). There was no significant difference between anthropometric measurements, Celiac Disease Questionnaire scores, daily energy, and nutrient intakes of groups (P > .05). Conclusion: The content of a gluten-free diet has a decisive role in the nutritional status and quality of life of celiac patients. Additionally, zonulin levels and intestinal permeability were higher in people with celiac disease who are non-compliant to gluten-free diet.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Ludvigsson JF, Leffler DA, Bai JC, et al. The Oslo definitions for coeliac disease and related terms. Gut. 2013;62(1):43-52. [CrossRef]
- 2. Choi W, Yeruva S, Turner JR. Contributions of intestinal epithelial barriers to health and disease. Exp Cell Res. 2017;358(1):71-77. [CrossRef]
- 3. Fasano A. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol Hepatol. 2012;10(10):1096-1100. [CrossRef]
- 4. Lammers KM, Lu R, Brownley J, et al. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology. 2008;135(1):194- 204.e3. [CrossRef]
- 5. Schumann M, Siegmund B, Schulzke JD, Fromm M. Celiac disease: role of the epithelial barrier. Cell Mol Gastroenterol Hepatol. 2017;3(2):150-162. [CrossRef]
- 6. Duerksen DR, Wilhelm-Boyles C, Parry DM. Intestinal permeability in long-term follow-up of patients with celiac disease on a glutenfree diet. Dig Dis Sci. 2005;50(4):785-790. [CrossRef]
- 7. Larretxi I, Txurruka I, Navarro V, et al. Micronutrient analysis of gluten-free products: their low content is not involved in gluten-free diet imbalance in a cohort of celiac children and adolescent. Foods. 2019;8(8):321. [CrossRef]
- 8. Häuser W, Gold J, Stallmach A, Caspary WF, Stein J. Development and validation of the Celiac Disease Questionnaire (CDQ), A disease-specific health-related quality of life measure for adult patients with celiac disease. J Clin Gastroenterol. 2007;41(2):157- 166. [CrossRef]
- 9. Aksan A, Mercanlıgil SM, Häuser W, Karaismailoğlu E. Validation of the Turkish version of the Celiac Disease Questionnaire (CDQ). Health Qual Life Outcomes. 2015;13:82. [CrossRef]
- 10. Paganizza S, Zanotti R, D’Odorico A, Scapolo P, Canova C. Is adherence to a gluten-free diet by adult patients with celiac disease influenced by their knowledge of the gluten content of foods? Gastroenterol Nurs. 2019;42(1):55-64. [CrossRef]
- 11. Leffler DA, Edwards George JB, Dennis M, Cook EF, Schuppan D, Kelly CP. A prospective comparative study of five measures of gluten- free diet adherence in adults with coeliac disease. Aliment Pharmacol Ther. 2007;26(9):1227-1235. [CrossRef]
- 12. Türkiye Beslenme rehberi 2015. Available at: https://hsgm.saglik. gov.tr/depo/birimler/saglikli-beslenme-hareketli-hayat-db/Yayi nlar/ rehberler/2015-beslenme-rehberi.pdf Accessed November 28, 2019.
- 13. BMI classification. Geneva: World Health Organization; Available at: https://www.who.int/europe/news-room/fact-sheets/item/a-he a lthylifestyle--- who-recommendations. Accessed November 16, 2019.
- 14. Vojdani A, Vojdani E, Kharrazian D. Fluctuation of zonulin levels in blood vs stability of antibodies. World J Gastroenterol. 2017;23(31):5669-5679. [CrossRef]
- 15. Duerksen DR, Wilhelm-Boyles C, Veitch R, Kryszak D, Parry DM. A comparison of antibody testing, permeability testing, and zonulin levels with small-bowel biopsy in celiac disease patients on a glutenfree diet. Dig Dis Sci. 2010;55(4):1026-1031. [CrossRef]
- 16. Leffler DA, Kelly CP, Green PH, et al. Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial. Gastroenterology. 2015;148(7):1311-9.e6. [CrossRef]
- 17. Kreutz JM, Adriaanse MPM, van der Ploeg EMC, Vreugdenhil ACE. Narrative review: nutrient deficiencies in adults and children with treated and untreated celiac disease. Nutrients. 2020;12(2):500. [CrossRef]
- 18. Moya DA, Nugent CA, Baker RD, Baker SS. Celiac disease nutritional status and poor adherence to follow-up. Clin Pediatr (Phila). 2020;59(7):649-655. [CrossRef]
- 19. Serin Y, Akbulut G. Nutritional status and health-related quality of life in adult patients with celiac disease. Proceedings CBU International Conference. 2018;6:952-959. [CrossRef]
- 20. Vici G, Belli L, Biondi M, Polzonetti V. Gluten-free diet and nutrient deficiencies: a review. Clin Nutr. 2016;35(6):1236-1241. [CrossRef]
- 21. Barone M, Della Valle N, Rosania R, et al. A comparison of the nutritional status between adult celiac patients on a long-term, strictly gluten-free diet and healthy subjects. Eur J Clin Nutr. 2016;70(1):23-27. [CrossRef]
- 22. Taetzsch A, Das SK, Brown C, Krauss A, Silver RE, Roberts SB. Are gluten-free diets more nutritious? An evaluation of self-selected and recommended gluten-free and gluten-containing dietary patterns. Nutrients. 2018;10(12):1881. [CrossRef]
- 23. Rondanelli M, Faliva MA, Gasparri C, et al. Micronutrients dietary supplementation advices for celiac patients on long-term glutenfree diet with good compliance: a review. Medicina (Kaunas). 2019;55(7):1-17. [CrossRef]
- 24. Ukkola A, Mäki M, Kurppa K, et al. hauChanges in body mass index on a gluten-free diet in coeliac disease: a nationwide study. Eur J Intern Med. 2012;23(4):384-388. [CrossRef]
- 25. Kabbani TA, Goldberg A, Kelly CP, et al. Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet. Aliment Pharmacol Ther. 2012;35(6):723-729. [CrossRef]
- 26. Marsilio I, Canova C, D’Odorico A, et al. Quality-of-life evaluation in coeliac patients on a gluten-free diet. Nutrients. 2020; 12(10):2981. [CrossRef]
- 27. Deepak C, Berry N, Vaiphei K, Dhaka N, Sinha SK, Kochhar R. Quality of life in celiac disease and the effect of gluten free diet. JGH Open. 2018; 2(4):124-128. [CrossRef]
- 28. BurgerJPW, de Brouwer B, IntHout J, Wahab PJ, Tummers M, Drenth JPH. Systematic review with meta-analysis: dietary adherence influences normalization of health-related quality of life in coeliac disease. Clin Nutr. 2017;36(2):399-406. [CrossRef]
| APA | Öztekin Y, GUNES G, alahdab y (2022). The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease. , 1043 - 1049. 10.5152/tjg.2022.21815 |
| Chicago | Öztekin Yeşim,GUNES Gunes,alahdab yesim The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease. (2022): 1043 - 1049. 10.5152/tjg.2022.21815 |
| MLA | Öztekin Yeşim,GUNES Gunes,alahdab yesim The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease. , 2022, ss.1043 - 1049. 10.5152/tjg.2022.21815 |
| AMA | Öztekin Y,GUNES G,alahdab y The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease. . 2022; 1043 - 1049. 10.5152/tjg.2022.21815 |
| Vancouver | Öztekin Y,GUNES G,alahdab y The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease. . 2022; 1043 - 1049. 10.5152/tjg.2022.21815 |
| IEEE | Öztekin Y,GUNES G,alahdab y "The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease." , ss.1043 - 1049, 2022. 10.5152/tjg.2022.21815 |
| ISNAD | Öztekin, Yeşim vd. "The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease". (2022), 1043-1049. https://doi.org/10.5152/tjg.2022.21815 |
| APA | Öztekin Y, GUNES G, alahdab y (2022). The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease. Turkish Journal of Gastroenterology, 33(12), 1043 - 1049. 10.5152/tjg.2022.21815 |
| Chicago | Öztekin Yeşim,GUNES Gunes,alahdab yesim The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease. Turkish Journal of Gastroenterology 33, no.12 (2022): 1043 - 1049. 10.5152/tjg.2022.21815 |
| MLA | Öztekin Yeşim,GUNES Gunes,alahdab yesim The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease. Turkish Journal of Gastroenterology, vol.33, no.12, 2022, ss.1043 - 1049. 10.5152/tjg.2022.21815 |
| AMA | Öztekin Y,GUNES G,alahdab y The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease. Turkish Journal of Gastroenterology. 2022; 33(12): 1043 - 1049. 10.5152/tjg.2022.21815 |
| Vancouver | Öztekin Y,GUNES G,alahdab y The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease. Turkish Journal of Gastroenterology. 2022; 33(12): 1043 - 1049. 10.5152/tjg.2022.21815 |
| IEEE | Öztekin Y,GUNES G,alahdab y "The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease." Turkish Journal of Gastroenterology, 33, ss.1043 - 1049, 2022. 10.5152/tjg.2022.21815 |
| ISNAD | Öztekin, Yeşim vd. "The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease". Turkish Journal of Gastroenterology 33/12 (2022), 1043-1049. https://doi.org/10.5152/tjg.2022.21815 |
