Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism

Objective: Attention and learning problems have been reported in children diagnosed with subclinic hypothyroidism (SH). Sensory gating is an automatic phenomenon that is related to attentional processes. It is known that an impairment in sensory/sensorimotor gating negatively affects the signal processing mechanism and hence attention and learning processes. The aim of the present study was to evaluate the effect of SH on sensory gating processes via P50 suppression and prepulse inhibition (PPI) in children. Methods: Fifteen children aged 8-16 years, diagnosed with SH, and 15 healthy children were included in the study. Auditory P50 suppression and PPI paradigms were applied during the recordings. P50 suppression was examined via auditory brain potentials recorded by electroencephalography. PPI was evaluated via electromyography, in which the blink reflex was recorded by oculomotor muscle activity. Results: No statistical difference was found in P50 suppression and PPI processes between children in the SH and control groups. These findings indicate that the sensory gating processes children with SH are not affected. Conclusion: The findings of this study show that the sensory gating processes of SH children are not affected. However, considering that brain maturation continues until the age of 20s, it may be more useful to scrutinize these processes with a wider age range and a larger number of participants to reveal more clearly how sensory gating is affected by SH.

Anahtar Kelime:

Subklinik Hipotiroidili Çocuklarda Duyusal ve Duyusal Motor Kapılama

Öz:

Amaç: Subklinik hipotiroidi (SH) tanısı almış olan çocuklarda dikkat ve öğrenme problemleri bildirilmiştir. Duyusal perdeleme, dikkat süreçleri ile ilişkili otomatik bir olgudur. Duyusal perdelemenin bozulması, sinyallerin işlenme mekanizmasını ve dolayısıyla dikkat ve öğrenme süreçlerini olumsuz etkilediği bilinmektedir. Bu çalışmanın amacı, SH’nin çocukların duyusal perdeleme süreçleri üzerindeki etkisini P50 baskılama ve prepulse inhibisyonu (PPI) ile değerlendirmektir. Yöntem: SH tanısı alan 8-16 yaş aralığında 15 çocuk hasta ve 15 sağlıklı çocuk çalışmaya alındı. Kayıtlar sırasında işitsel P50 baskılama ve PPI paradigmaları uygulandı. P50 baskılama süreçleri, elektroensefalografi ile kaydedilen işitsel beyin potansiyelleri ile incelendi. PPI ise, göz kırpma refleksinin okülomotor kas aktivitesi ile kaydedildiği elektrookülografi ile değerlendirildi. Bulgular: SH ve kontrol grubunda bulunan çocukların P50 baskılama ve PPI süreçleri arasında istatistiksel farklılık bulunmamıştır. Bu bulgular, SH çocukların duyusal perdeleme süreçlerinin etkilenmemiş olduğunu göstermektedir. Sonuç: Bu çalışmanın bulguları, SH çocukların duyusal perdeleme süreçlerinin etkilenmemiş olduğunu göstermektedir. Fakat, beynin olgunlaşma sürecinin 20’li yaşlara kadar devam ettiğini göz önüne alarak, bu süreçlerin çocuklarda SH’den nasıl etkilendiğini anlayabilmek için daha geniş yaş aralığında ve daha büyük sayıda katılımcı ile incelenmesi gereklidir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kocaaslan Atli S, Olgac Dundar N, Erdogan U, Evirgen Esin N, BAYAZIT T, Kahya M, Çatlı G, GENÇPINAR P, Dundar B (2023). Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism. , 26 - 32. 10.4274/terh.galenos.2021.68815
Chicago	Kocaaslan Atli Sibel,Olgac Dundar Nihal,Erdogan Ugras,Evirgen Esin Nur,BAYAZIT Turan Onur,Kahya Mehmet Cemal,Çatlı Gönül,GENÇPINAR PINAR,Dundar Bumin N Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism. (2023): 26 - 32. 10.4274/terh.galenos.2021.68815
MLA	Kocaaslan Atli Sibel,Olgac Dundar Nihal,Erdogan Ugras,Evirgen Esin Nur,BAYAZIT Turan Onur,Kahya Mehmet Cemal,Çatlı Gönül,GENÇPINAR PINAR,Dundar Bumin N Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism. , 2023, ss.26 - 32. 10.4274/terh.galenos.2021.68815
AMA	Kocaaslan Atli S,Olgac Dundar N,Erdogan U,Evirgen Esin N,BAYAZIT T,Kahya M,Çatlı G,GENÇPINAR P,Dundar B Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism. . 2023; 26 - 32. 10.4274/terh.galenos.2021.68815
Vancouver	Kocaaslan Atli S,Olgac Dundar N,Erdogan U,Evirgen Esin N,BAYAZIT T,Kahya M,Çatlı G,GENÇPINAR P,Dundar B Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism. . 2023; 26 - 32. 10.4274/terh.galenos.2021.68815
IEEE	Kocaaslan Atli S,Olgac Dundar N,Erdogan U,Evirgen Esin N,BAYAZIT T,Kahya M,Çatlı G,GENÇPINAR P,Dundar B "Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism." , ss.26 - 32, 2023. 10.4274/terh.galenos.2021.68815
ISNAD	Kocaaslan Atli, Sibel vd. "Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism". (2023), 26-32. https://doi.org/10.4274/terh.galenos.2021.68815

APA	Kocaaslan Atli S, Olgac Dundar N, Erdogan U, Evirgen Esin N, BAYAZIT T, Kahya M, Çatlı G, GENÇPINAR P, Dundar B (2023). Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism. İzmir Tepecik Eğitim Hastanesi Dergisi, 33(1), 26 - 32. 10.4274/terh.galenos.2021.68815
Chicago	Kocaaslan Atli Sibel,Olgac Dundar Nihal,Erdogan Ugras,Evirgen Esin Nur,BAYAZIT Turan Onur,Kahya Mehmet Cemal,Çatlı Gönül,GENÇPINAR PINAR,Dundar Bumin N Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism. İzmir Tepecik Eğitim Hastanesi Dergisi 33, no.1 (2023): 26 - 32. 10.4274/terh.galenos.2021.68815
MLA	Kocaaslan Atli Sibel,Olgac Dundar Nihal,Erdogan Ugras,Evirgen Esin Nur,BAYAZIT Turan Onur,Kahya Mehmet Cemal,Çatlı Gönül,GENÇPINAR PINAR,Dundar Bumin N Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism. İzmir Tepecik Eğitim Hastanesi Dergisi, vol.33, no.1, 2023, ss.26 - 32. 10.4274/terh.galenos.2021.68815
AMA	Kocaaslan Atli S,Olgac Dundar N,Erdogan U,Evirgen Esin N,BAYAZIT T,Kahya M,Çatlı G,GENÇPINAR P,Dundar B Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism. İzmir Tepecik Eğitim Hastanesi Dergisi. 2023; 33(1): 26 - 32. 10.4274/terh.galenos.2021.68815
Vancouver	Kocaaslan Atli S,Olgac Dundar N,Erdogan U,Evirgen Esin N,BAYAZIT T,Kahya M,Çatlı G,GENÇPINAR P,Dundar B Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism. İzmir Tepecik Eğitim Hastanesi Dergisi. 2023; 33(1): 26 - 32. 10.4274/terh.galenos.2021.68815
IEEE	Kocaaslan Atli S,Olgac Dundar N,Erdogan U,Evirgen Esin N,BAYAZIT T,Kahya M,Çatlı G,GENÇPINAR P,Dundar B "Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism." İzmir Tepecik Eğitim Hastanesi Dergisi, 33, ss.26 - 32, 2023. 10.4274/terh.galenos.2021.68815
ISNAD	Kocaaslan Atli, Sibel vd. "Sensory and Sensorimotor Gating in Children with Subclinical Hypothyroidism". İzmir Tepecik Eğitim Hastanesi Dergisi 33/1 (2023), 26-32. https://doi.org/10.4274/terh.galenos.2021.68815