Obezite Yönetiminde Adipoz Doku Kahverengileşmesi

Başkent, Hümeyra; Barut, Figen; ASLAN ÇİN, NAZLI NUR; BAYRAKTAROĞLU, TANER

doi:10.25048/tudod.1250627

Obezite Yönetiminde Adipoz Doku Kahverengileşmesi

Hümeyra BAŞKENT, (Ankara Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Ankara, Türkiye)

Nazlı Nur ASLAN ÇİN, (Karadeniz Teknik Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Trabzon, Türkiye)

Taner BAYRAKTAROĞLU, (Zonguldak Bülent Ecevit Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Anabilim Dalı, Zonguldak, Türkiye)

Figen BARUT (Zonguldak Bülent Ecevit Üniversitesi, Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, Zonguldak, Türkiye)

Türkiye Diyabet ve Obezite Dergisi

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Yıl: 2023 Cilt: 7 Sayı: 1 Sayfa Aralığı: 81 - 91 Metin Dili: Türkçe DOI: 10.25048/tudod.1250627 İndeks Tarihi: 08-06-2023

Obezite Yönetiminde Adipoz Doku Kahverengileşmesi

Öz:

Tüm dünya sorunu olan obezitenin tedavisinde güncel olarak terapötik stratejiler geliştirilmektedir. Memelilerde, işlevleri ve morfolojileri bakımından farklılık gösteren farklı iki tip adipoz doku mevcuttur. Bunlar, embriyogenez sırasında ortaya çıkan kahverengi adipoz doku (KAD); ve doğum sonrası gelişen beyaz adipoz dokudur (BAD). KAD’nun hacmi, enerji harcaması ile pozitif ilişkili olduğu ve obez kişilerde zayıf bireylere göre önemli ölçüde düşük olduğu bilinmektedir. KAD indüksiyonunu ve/veya aktivasyonunu hedefleyen stratejiler, obezite tedavisinde potansiyel olarak faydalı olabileceği düşünülmektedir. Son yıllarda yapılan araştırmalar, KAD aktivasyonu ve BAD kahverengileşmesi ile ilgili mekanizmalar üzerine olan ilgiyi önemli ölçüde artırmaktadır. Bu mekanizmaları amaçlayan kimyasal bileşiklerin yanı sıra çeşitli farmakolojik olmayan bazı müdahale yaklaşımları bulunmaktadır. Bu derlemede, KAD aktivasyonu ve BAD kahverengileşmesi sürecindeki potansiyel terapötik hedefler ve bunları amaçlayan mevcut stratejilere ilişkin kavramlar özetlenmiştir

Anahtar Kelime: Kahverengi adipoz doku beyaz adipoz doku adipoz doku kahverengileşmesi termogenez obezite

Adipose Tissue Browning in Obesity Management

Öz:

Recently, therapeutic strategies have been developed for the treatment of obesity, which is a worldwide problem. There are two different types of adipose tissue in mammals that differ in their function and morphology. These are brown adipose tissue (BAT), which develops during embryogenesis and white adipose tissue (WAT), which develops after postnatal. It is known that the volume of BAT is positively associated with energy discharge and is significantly lower in obese individuals than in slim individuals. Strategies targeting the BAT induction and/or activation are considered potentially useful in the treatment of obesity. Recent research initiatives have significantly attracted the interest in the mechanisms associated with the BAT activation and WAT browning. In addition to the chemical compounds focusing on these mechanisms, there are various non-pharmacological intervention approaches. In this review, potential therapeutic targets in BAT activation and WAT browning process as well as the concepts related to the strategies targeting them are summarized

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Başkent H, ASLAN ÇİN N, BAYRAKTAROĞLU T, Barut F (2023). Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. , 81 - 91. 10.25048/tudod.1250627
Chicago	Başkent Hümeyra,ASLAN ÇİN NAZLI NUR,BAYRAKTAROĞLU TANER,Barut Figen Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. (2023): 81 - 91. 10.25048/tudod.1250627
MLA	Başkent Hümeyra,ASLAN ÇİN NAZLI NUR,BAYRAKTAROĞLU TANER,Barut Figen Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. , 2023, ss.81 - 91. 10.25048/tudod.1250627
AMA	Başkent H,ASLAN ÇİN N,BAYRAKTAROĞLU T,Barut F Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. . 2023; 81 - 91. 10.25048/tudod.1250627
Vancouver	Başkent H,ASLAN ÇİN N,BAYRAKTAROĞLU T,Barut F Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. . 2023; 81 - 91. 10.25048/tudod.1250627
IEEE	Başkent H,ASLAN ÇİN N,BAYRAKTAROĞLU T,Barut F "Obezite Yönetiminde Adipoz Doku Kahverengileşmesi." , ss.81 - 91, 2023. 10.25048/tudod.1250627
ISNAD	Başkent, Hümeyra vd. "Obezite Yönetiminde Adipoz Doku Kahverengileşmesi". (2023), 81-91. https://doi.org/10.25048/tudod.1250627

APA	Başkent H, ASLAN ÇİN N, BAYRAKTAROĞLU T, Barut F (2023). Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Türkiye Diyabet ve Obezite Dergisi , 7(1), 81 - 91. 10.25048/tudod.1250627
Chicago	Başkent Hümeyra,ASLAN ÇİN NAZLI NUR,BAYRAKTAROĞLU TANER,Barut Figen Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Türkiye Diyabet ve Obezite Dergisi 7, no.1 (2023): 81 - 91. 10.25048/tudod.1250627
MLA	Başkent Hümeyra,ASLAN ÇİN NAZLI NUR,BAYRAKTAROĞLU TANER,Barut Figen Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Türkiye Diyabet ve Obezite Dergisi , vol.7, no.1, 2023, ss.81 - 91. 10.25048/tudod.1250627
AMA	Başkent H,ASLAN ÇİN N,BAYRAKTAROĞLU T,Barut F Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Türkiye Diyabet ve Obezite Dergisi . 2023; 7(1): 81 - 91. 10.25048/tudod.1250627
Vancouver	Başkent H,ASLAN ÇİN N,BAYRAKTAROĞLU T,Barut F Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Türkiye Diyabet ve Obezite Dergisi . 2023; 7(1): 81 - 91. 10.25048/tudod.1250627
IEEE	Başkent H,ASLAN ÇİN N,BAYRAKTAROĞLU T,Barut F "Obezite Yönetiminde Adipoz Doku Kahverengileşmesi." Türkiye Diyabet ve Obezite Dergisi , 7, ss.81 - 91, 2023. 10.25048/tudod.1250627
ISNAD	Başkent, Hümeyra vd. "Obezite Yönetiminde Adipoz Doku Kahverengileşmesi". Türkiye Diyabet ve Obezite Dergisi 7/1 (2023), 81-91. https://doi.org/10.25048/tudod.1250627