Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients
Yıl: 2023 Cilt: 33 Sayı: 1 Sayfa Aralığı: 85 - 93 Metin Dili: İngilizce DOI: 10.4274/terh.galenos.2022.82997 İndeks Tarihi: 05-05-2023
Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients
Öz: Objective: This study evaluated extensive intraoperative peritoneal lavage (EIPL) on overall survival (OS), adverse events, and recurrence type in gastric cancer patients who underwent curative D2 lymph node dissection. Methods: Medical records of 235 patients undergoing D2 curative gastrectomy for clinically locally advanced gastric cancer without peritoneal carcinomatosis between January 2011 and October 2021 were reviewed retrospectively. Patients were grouped according to surgery plus EIPL and non-EIPL. Clinicopathological features and recurrence type, prognostic factors on OS, and incidence of adverse events were evaluated. Results: The mean age of patients included in this study was 63 years in the EIPL group and 61 in the non-EIPL group. The OS rate of patients with EIPL was 63%, and the non-EIPL group was 61.6%. All postoperative complications were less in the EIPL group (p=0.008). Peritoneal metastases were less in the EIPL group (p=0.003). Conclusion: Free cancer cells in the abdominal cavity may be detected due of tumor manipulation and lymphovascular dissection during surgery. Using EIPL can reduce peritoneal recurrence. Postoperative complications due to exudate, debris, and possible intestinal content caused by perioperative dissection can be prevented with EIPL.
Anahtar Kelime: Lokal İleri Mide Kanseri Hastalarının Tedavisinde Küratif D2 Rezeksiyonu Sonrası İzotonik Sıvı ile Extensive Peritoneal Lavage (EIPL)
Öz: Amaç: Bu çalışmanın amacı, küratif D2 lenf nodu diseksiyonu uygulanan mide kanseri hastalarında ekstensiv intraoperative peritoneal lavaj (EIPL) yapılmasının sağkalım, nüks tipi ve postoperatif komplikasyonlar üzerindeki etkisini araştırmaktır. Yöntem: Ocak 2011 ile Ekim 2021 arasında klinik olarak lokal ileri mide kanseri nedeniyle küratif gastrektomi ve D2 lenf nodu diseksiyonu uygulanan periton metastazı olmayan 235 hastanın kayıtları geriye dönük olarak incelendi. Cerrahi sonrası EIPL yapılan ve yapılmayan hastalar değerlendirildi. Genel sağkalım (OS), nüks tipi, klinikopatolojik özellikler ve postoperative komplikasyonlar değerlendirildi. EIPL yapılan ve EIPL yapılmayan (non-EIPL) hasta grupları karşılaştırıldı. Bulgular: Çalışmaya dahil edilen hastaların ortalama yaşı non-EIPL grubunda 61, EIPL grubunda 63 idi. OS oranı EIPL grubunda %63, non-EIPL grubunda ise %61,6 idi. Tüm postoperatif komplikasyonlar EIPL grubunda daha azdı (p=0,008). Peritoneal metastaz EIPL grubunda daha azdı (p=0,003). Sonuç: Cerrahi rezeksiyon sırasında tümör manipülasyonu ve lenfovasküler diseksiyona bağlı intraabdominal kavitede serbest kanser hücreleri görülebilir. EIPL uygulanması ile iatrojenik serbest kanser hücreleri peritoneal implantasyonu gelişmesi azaltılabilir. Peroperatif diseksiyona bağlı periton içerisine dökülen debrislerin, eksudanın ve muhtemel barsak içeriğinin EIPL ile yok edilmesiyle postoperatif komplikasyonlar azaltılabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | alemdar a, duman m, şengiz erhan s, GUNER A, Yılmaz İ (2023). Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients. , 85 - 93. 10.4274/terh.galenos.2022.82997 |
| Chicago | alemdar ali,duman mehmet güray,şengiz erhan selma,GUNER Ali,Yılmaz İsmayil Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients. (2023): 85 - 93. 10.4274/terh.galenos.2022.82997 |
| MLA | alemdar ali,duman mehmet güray,şengiz erhan selma,GUNER Ali,Yılmaz İsmayil Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients. , 2023, ss.85 - 93. 10.4274/terh.galenos.2022.82997 |
| AMA | alemdar a,duman m,şengiz erhan s,GUNER A,Yılmaz İ Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients. . 2023; 85 - 93. 10.4274/terh.galenos.2022.82997 |
| Vancouver | alemdar a,duman m,şengiz erhan s,GUNER A,Yılmaz İ Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients. . 2023; 85 - 93. 10.4274/terh.galenos.2022.82997 |
| IEEE | alemdar a,duman m,şengiz erhan s,GUNER A,Yılmaz İ "Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients." , ss.85 - 93, 2023. 10.4274/terh.galenos.2022.82997 |
| ISNAD | alemdar, ali vd. "Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients". (2023), 85-93. https://doi.org/10.4274/terh.galenos.2022.82997 |
| APA | alemdar a, duman m, şengiz erhan s, GUNER A, Yılmaz İ (2023). Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients. İzmir Tepecik Eğitim Hastanesi Dergisi, 33(1), 85 - 93. 10.4274/terh.galenos.2022.82997 |
| Chicago | alemdar ali,duman mehmet güray,şengiz erhan selma,GUNER Ali,Yılmaz İsmayil Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients. İzmir Tepecik Eğitim Hastanesi Dergisi 33, no.1 (2023): 85 - 93. 10.4274/terh.galenos.2022.82997 |
| MLA | alemdar ali,duman mehmet güray,şengiz erhan selma,GUNER Ali,Yılmaz İsmayil Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients. İzmir Tepecik Eğitim Hastanesi Dergisi, vol.33, no.1, 2023, ss.85 - 93. 10.4274/terh.galenos.2022.82997 |
| AMA | alemdar a,duman m,şengiz erhan s,GUNER A,Yılmaz İ Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients. İzmir Tepecik Eğitim Hastanesi Dergisi. 2023; 33(1): 85 - 93. 10.4274/terh.galenos.2022.82997 |
| Vancouver | alemdar a,duman m,şengiz erhan s,GUNER A,Yılmaz İ Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients. İzmir Tepecik Eğitim Hastanesi Dergisi. 2023; 33(1): 85 - 93. 10.4274/terh.galenos.2022.82997 |
| IEEE | alemdar a,duman m,şengiz erhan s,GUNER A,Yılmaz İ "Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients." İzmir Tepecik Eğitim Hastanesi Dergisi, 33, ss.85 - 93, 2023. 10.4274/terh.galenos.2022.82997 |
| ISNAD | alemdar, ali vd. "Extensive Peritoneal Lavage (EIPL) with Saline After Curative D2 Gastric Resection For Treatment of Locally Advanced Gastric Cancer Patients". İzmir Tepecik Eğitim Hastanesi Dergisi 33/1 (2023), 85-93. https://doi.org/10.4274/terh.galenos.2022.82997 |
