Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel

Comoglu, Tansel

doi:10.14235/bas.galenos.2022.40427

Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel

Tansel ÇOMOĞLU (Ankara Üniversitesi Eczacılık Fakültesi Farmasötik Teknoloji Anabilim Dalı, Ankara, Türkiye)

Bezmiâlem Science

6 1

Yıl: 2022 Cilt: 10 Sayı: 6 Sayfa Aralığı: 735 - 741 Metin Dili: İngilizce DOI: 10.14235/bas.galenos.2022.40427 İndeks Tarihi: 05-05-2023

Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel

Öz:

Objective: Controlled local release of temozolomide (TMZ) at the tumor site is a new strategy in the treatment of glioblastoma. Localized delivery systems, based on biodegradable polymers, are capable of slowing and controlling the drug release for a certain period of time. Therefore, the main objective of the study was to investigate a new approach for encapsulating TMZ in a poly(lacticco- glycolic acid) nanoparticle (NP) system which was then formulated in 18% Pluronic® hydrogel matrix which would provide a sustained and local delivery of TMZ. Methods: Hydrogels are investigated as local drug delivery methods due to their tunable characteristics and capacity to retain labile pharmaceuticals. The lack of established procedures for describing and evaluating drug release, on the other hand, offers considerable problems, impeding reliable evaluation of systems for defining drug release characteristics. Results: In this part our study, we aimed to research drug release kinetics of TMZ NPs which had an encapsulation efficiency and particle size ranging between 52-69.67% and 164.4-235.5 nm from a novel hydrogel drug delivery system. Conclusion: The application of mathematical modeling proves to be extremely beneficial for estimating the release kinetics before the release systems are implemented. The release mechanism was found to be diffusion controlled and not accompanied by dissolution of matrix.

Anahtar Kelime:

Pluronic® F-127 Hidrojel İçinde Temozolomid Yüklü PLGA Nanopartiküllerinden İlaç Salım Kinetiklerinin Değerlendirilmesi

Öz:

Amaç: Tümör bölgesinde temolozomid’in (TMZ) kontrollü lokal salınımı, glioblastomanın tedavisinde yeni bir stratejidir. Biyobozunur polimerlere dayanan lokalize dağıtım sistemleri, belirli bir süre boyunca ilaç salınımını yavaşlatabilir ve kontrol edebilir. Bu nedenle, çalışmanın ana amacı, TMZ’nin sürekli ve yerel bir dağıtımını sağlayacak olan %18 Pluronic® hidrojel matrisinde formüle edilen bir poli(laktik-ko-glikolik asit) nanoparçacık (NP) sisteminde TMZ’yi kapsüllemek için yeni bir yaklaşımı araştırmaktı. Yöntemler: Hidrojeller, ayarlanabilir özellikleri ve kararsız farmasötikleri tutma kapasiteleri nedeniyle yerel ilaç dağıtım yöntemleri olarak hızla araştırılmaktadır. Öte yandan, ilaç salımını tanımlamaya ve değerlendirmeye yönelik yerleşik prosedürlerin olmaması, ilaç salım özelliklerini tanımlamaya yönelik sistemlerin güvenilir bir şekilde değerlendirilmesini engelleyen önemli sorunlar ortaya çıkarmaktadır. Bulgular: Yeni bir hidrojel ilaç taşıma sisteminden 164,4-235,5 nm arasında değişen partikül boyutu ve %52-69,67 kapsülleme etkinliğine sahip TMZ NP’lerin in vitro ilaç salım kinetiğini araştırmayı amaçladık. Sonuç: Serbest bırakma sistemleri uygulanmadan önce serbest bırakma kinetiğini tahmin etmek için matematiksel modellemenin kullanılmasının çok faydalı olduğu ortaya çıkmıştır. Salım mekanizmasının difüzyon kontrollü olduğu ve matriksin çözünmesinin eşlik etmediği bulundu.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Comoglu T (2022). Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel. , 735 - 741. 10.14235/bas.galenos.2022.40427
Chicago	Comoglu Tansel Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel. (2022): 735 - 741. 10.14235/bas.galenos.2022.40427
MLA	Comoglu Tansel Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel. , 2022, ss.735 - 741. 10.14235/bas.galenos.2022.40427
AMA	Comoglu T Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel. . 2022; 735 - 741. 10.14235/bas.galenos.2022.40427
Vancouver	Comoglu T Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel. . 2022; 735 - 741. 10.14235/bas.galenos.2022.40427
IEEE	Comoglu T "Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel." , ss.735 - 741, 2022. 10.14235/bas.galenos.2022.40427
ISNAD	Comoglu, Tansel. "Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel". (2022), 735-741. https://doi.org/10.14235/bas.galenos.2022.40427

APA	Comoglu T (2022). Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel. Bezmiâlem Science, 10(6), 735 - 741. 10.14235/bas.galenos.2022.40427
Chicago	Comoglu Tansel Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel. Bezmiâlem Science 10, no.6 (2022): 735 - 741. 10.14235/bas.galenos.2022.40427
MLA	Comoglu Tansel Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel. Bezmiâlem Science, vol.10, no.6, 2022, ss.735 - 741. 10.14235/bas.galenos.2022.40427
AMA	Comoglu T Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel. Bezmiâlem Science. 2022; 10(6): 735 - 741. 10.14235/bas.galenos.2022.40427
Vancouver	Comoglu T Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel. Bezmiâlem Science. 2022; 10(6): 735 - 741. 10.14235/bas.galenos.2022.40427
IEEE	Comoglu T "Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel." Bezmiâlem Science, 10, ss.735 - 741, 2022. 10.14235/bas.galenos.2022.40427
ISNAD	Comoglu, Tansel. "Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic® F-127 Hydrogel". Bezmiâlem Science 10/6 (2022), 735-741. https://doi.org/10.14235/bas.galenos.2022.40427