Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model
Yıl: 2023 Cilt: 29 Sayı: 2 Sayfa Aralığı: 125 - 135 Metin Dili: İngilizce DOI: 10.9775/kvfd.2022.28697 İndeks Tarihi: 05-05-2023
Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model
Öz: In this study, it was aimed to investigate the effects of tarantula cubensis extract (TCE) and low-level laser therapy (LLLT) on cancellous and cortical bone repair. A circular unicortical bone defect was created on both the cancellous and cortical regions of the tibia of each subject. The subjects, totaling 54 mature New Zealand rabbits, were randomly allocated into three groups (n:18 each): control, LLLT (Galium-aliminum-arsenide laser at a wavelength of 780 nm and 4 J/cm 2, 5 min/day) and TCE (1 μg/kg) groups. Relative optic density (ROD) level was higher in the TCE group than the control group on day 28 as radiological (P<0.05). In both cancellous and cortical bone, inflammatory cell densities were less on the 14 and 21st day in the TCE and LLLT groups, bone tissue formation and qualities were higher 7 and 14th days in TCE and LLLT and collagen maturation were higher 28th day in the TCE group as histopathological (P<0.05). In this study, TCE accelerates bone repair as much as LLLT and more than the control group. In conclusion, that TCE is an effective, easier to apply and more economical supportive treatment in bone defects like LLLT.
Anahtar Kelime: Tarantula Cubensis Ekstraktı ve Düşük Seviye Lazer Tedavisi: Deneysel Kemik Defekti Modelinde Kemik Onarımının Histopatolojik, Radyolojik ve Serolojik Analizi
Öz: Bu çalışmada tarantula cubensis ekstraktı (TCE) ve düşük seviyeli lazer tedavisinin (LLLT) süngerimsi ve kortikal kemik onarımı üzerindeki etkilerinin araştırılması amaçlandı. Her deneğin tibiasının hem süngerimsi hem de kortikal bölgelerinde sirküler unikortikal kemik defekti oluşturuldu. Toplam 54 olgun Yeni Zelanda tavşanından oluşan denekler rastgele üç gruba ayrıldı (her biri n:18) kontrol, LLLT (780 nm dalga boyunda ve 4 J/cm2, 5 dk/gün’de Galium-alüminyum-arsenid lazer) ve TCE (1μg/kg) grupları. Rölatif optik yoğunluk (ROD) düzeyi radyolojik olarak 28. günde TCE ve LLLT gruplarında kontrol grubuna göre daha yüksekti (P<0.05). Histopatolojik olarak hem süngerimsi hem de kortikal kemikte, inflamatuvar hücre yoğunlukları 14. ve 21. günde TCE ve LLLT gruplarında daha azdı kemik dokusu oluşumu ve kalitesi 7. ve 14. günlerde TCE ve LLLT gruplarında daha yüksekti ve kollajen olgunlaşması 28. günde TCE grubunda daha yüksekti (P<0.05). Bu çalışmada TCE, kemik onarımını LLLT kadar ve kontrol grubuna göre daha fazla hızlandırmaktadır. Sonuç olarak, LLLT gibi kemik defektlerinde TÇE’nin etkili, uygulaması kolay ve ekonomik bir destekleyici tedavi olduğu sonucuna varıldı.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Altan S, sağsöz h, ERSÖZ KANAY B, ALTAN F, Alan E, ÇEVİK R (2023). Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model. , 125 - 135. 10.9775/kvfd.2022.28697 |
| Chicago | Altan Semih,sağsöz hakan,ERSÖZ KANAY Berna,ALTAN Feray,Alan Emel,ÇEVİK REMZİ Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model. (2023): 125 - 135. 10.9775/kvfd.2022.28697 |
| MLA | Altan Semih,sağsöz hakan,ERSÖZ KANAY Berna,ALTAN Feray,Alan Emel,ÇEVİK REMZİ Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model. , 2023, ss.125 - 135. 10.9775/kvfd.2022.28697 |
| AMA | Altan S,sağsöz h,ERSÖZ KANAY B,ALTAN F,Alan E,ÇEVİK R Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model. . 2023; 125 - 135. 10.9775/kvfd.2022.28697 |
| Vancouver | Altan S,sağsöz h,ERSÖZ KANAY B,ALTAN F,Alan E,ÇEVİK R Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model. . 2023; 125 - 135. 10.9775/kvfd.2022.28697 |
| IEEE | Altan S,sağsöz h,ERSÖZ KANAY B,ALTAN F,Alan E,ÇEVİK R "Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model." , ss.125 - 135, 2023. 10.9775/kvfd.2022.28697 |
| ISNAD | Altan, Semih vd. "Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model". (2023), 125-135. https://doi.org/10.9775/kvfd.2022.28697 |
| APA | Altan S, sağsöz h, ERSÖZ KANAY B, ALTAN F, Alan E, ÇEVİK R (2023). Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 29(2), 125 - 135. 10.9775/kvfd.2022.28697 |
| Chicago | Altan Semih,sağsöz hakan,ERSÖZ KANAY Berna,ALTAN Feray,Alan Emel,ÇEVİK REMZİ Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 29, no.2 (2023): 125 - 135. 10.9775/kvfd.2022.28697 |
| MLA | Altan Semih,sağsöz hakan,ERSÖZ KANAY Berna,ALTAN Feray,Alan Emel,ÇEVİK REMZİ Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.29, no.2, 2023, ss.125 - 135. 10.9775/kvfd.2022.28697 |
| AMA | Altan S,sağsöz h,ERSÖZ KANAY B,ALTAN F,Alan E,ÇEVİK R Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2023; 29(2): 125 - 135. 10.9775/kvfd.2022.28697 |
| Vancouver | Altan S,sağsöz h,ERSÖZ KANAY B,ALTAN F,Alan E,ÇEVİK R Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2023; 29(2): 125 - 135. 10.9775/kvfd.2022.28697 |
| IEEE | Altan S,sağsöz h,ERSÖZ KANAY B,ALTAN F,Alan E,ÇEVİK R "Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 29, ss.125 - 135, 2023. 10.9775/kvfd.2022.28697 |
| ISNAD | Altan, Semih vd. "Tarantula Cubensis Extract and Low-Level Laser Therapy: A Histopathological, Radiological and Serological Analysis of Bone Repair on an Experimental Bone Defect Model". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 29/2 (2023), 125-135. https://doi.org/10.9775/kvfd.2022.28697 |
