TY  - JOUR
TI  - THE PROTECTIVE EFFECTS OF TETRANDRINE AGAINST TO  HISTOLOGICAL, SPERMATOLOGICAL AND OXIDATIVE DAMAGE  INDUCED BY AROCLOR 1254 ON THE MALE RATS REPRODUCTIVE  SYSTEM
AB  - Objectives: Aroclor (AR) 1254; has many adverse effects on male  reproduction such as carcinogenic, teratogenic, immune and endocrine  disruption problems. Tetrandrine (TET), a bisbenzillisoquinoline alkaloid  isolated from the root of Stephania tetrandra S. Moore, has protective  effects such as immunomodulatory, anti-cancer, and anti-inflammatory.  The objective of this study was to investigate the possible curative effects  of TET therapy against testicular damage (histological, spermatological  and oxidative damage) induced by AR1254. Materials and Methods: Twenty-eight male rats were randomly divided  into four equal-sized groups: a control group; (1 ml of corn oil by gastric  oral gavage), AR1254 group; (2 mg/kg) AR1254 administered  intraperitoneally), TET group; (TET by gastric oral gavage 30 mg/kg) and  AR 1254 + TET group;(Aroclor 1254 and TET administered together at the  same doses as the previous groups.  Results: The AR1254 treatment caused morphological and spermatological  damage on testis tissue; oedema vacuolization and congestion, in  interstitial area, reduction in spermatogenic cells, arrested spermatocytes  at different stages of spermatogenesis, shedding of spermatogenic serial  cells into tubular lumens, a decline in epididymal sperm concentrations,  sperm motility and a rise in abnormal sperm ratios. The AR1254  administration induced an increase in the oxidative parameters and a  decrease in enzymatic and nonenzymatic antioxidant levels. The TET  treatment significantly ameliorated histological, oxidative, and sperm  damage caused by AR1254.  Conclusion: This study demonstrated the protective effects of TET against  AR1254-induced male rat reproductive damage.
AU  - aydın, muhterem
AU  - özdemir, feride
AU  - ÇETİN, Aslı
AU  - Ciftci, Osman
AU  - başak türkmen, neşe
DO  - 10.26650/JARHS2023-1181839
PY  - 2023
JO  - Sabiad 
VL  - 6
IS  - 1
SN  - 2651-4060
SP  - 80
EP  - 87
DB  - TRDizin
UR  - http://search/yayin/detay/1166746
ER  -