COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN  CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON  CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH  CHRONIC TOTAL OCCLUSION

Ayduk Gövdeli, Elif; Emet, Samim; Elitok, Ali; BAYKIZ, DERYA; Demirtakan, Zeynep Gizem

doi:10.26650/JARHS2023-1199242

COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION

Derya BAYKIZ, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Zeynep Gizem DEMİRTAKAN, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Elif AYDUK GÖVDELİ, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Samim EMET, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Ali ELİTOK (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Sabiad

3 3

Yıl: 2023 Cilt: 6 Sayı: 1 Sayfa Aralığı: 1 - 9 Metin Dili: İngilizce DOI: 10.26650/JARHS2023-1199242 İndeks Tarihi: 05-05-2023

COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION

Öz:

Objective: Coronary collateral circulation (CCC) plays a significant role in cardiovascular prognosis, and well-developed CCC improves survival. The aim of this study was to investigate whether the serum uric acid to high density lipoprotein cholesterol ratio (UA/HDL-C) is associated with coronary collateral development. Materials and Methods: This retrospective study enrolled 111 patients with stable coronary artery disease and at least one chronic total occlusion (CTO) at invasive coronary angiography. Blood samples were obtained from all patients before the angiography procedure. The collateral degree was determined according to the Rentrop scoring system. Patients were classified into a poor CCC group (Rentrop grades 0-1, n=47) or a good CCC group (Rentrop grades 2-3, n=64). The UA/HDL-C ratios were compared between the two groups. Results: The UA/HDL-C ratios were significantly higher in patients with poor CCC compared with the patients with good CCC (0.18 [0.06-0.49] vs 0.14 [0.05-0.31], respectively; p<0.001). In correlation analysis, the CCC was significantly negatively correlated with UA/HDL-C and UA levels (r=- 0.333, p<0.001; r=-0.502, p<0.001, respectively). According to the ROC analysis, a cut-off value of > 0.17 for the UA/HDL-C ratio predicted poor collateral development with 54.3% sensitivity and 79.3% specificity (AUC=0.711, 95% CI 0.617–0.794, p<0.001). In multivariate regression analysis, serum UA was found to be an independent predictor of poor collateral development (OR=2.818, p=0.022). Conclusion: The present study showed that although the UA/HDL-C ratio may be associated with poor collateral development, serum UA levels seem to be a better predictor of poor CCC than UA/HDL-C ratios in patients with CTO.

Anahtar Kelime:

KRONİK TOTAL OKLÜZYONU OLAN HASTALARDA ÜRİK ASİT YÜKSEK YOĞUNLUKLU LİPOPROTEİN KOLESTEROL ORANI VE SERUM ÜRİK ASİT DÜZEYLERİNİN KORONER KOLLATERAL DOLAŞIM ÜZERİNDE KARŞILAŞTIRILMASI

Öz:

Amaç: Koroner kollateral dolaşım (KKD) kardiyovasküler prognoz üzerinde önemli bir rol oynar ve iyi gelişmiş KKD surviyi iyileştirir. Bu çalışmanın amacı, serum ürik asit ve yüksek yoğunluklu lipoprotein kolesterol oranının (ÜA/ HDL-K) koroner kollateral gelişimi ile ilişkili olup olmadığını araştırmaktır. Gereç ve Yöntem: Bu retrospektif çalışmaya stabil koroner arter hastalığı ve invaziv koroner anjiyografide en az bir kronik total oklüzyonu (KTO) olan 111 hasta dahil edildi. Anjiyografi işlemi öncesi tüm hastalardan kan örnekleri alındı. Kollateral derecesi Rentrop sınıflamasına göre belirlendi. Hastalar kötü KKD grubu (Rentrop derece 0-1, n=47) veya iyi KKD grubu (Rentrop derece 2-3, n=64) olarak sınıflandırıldı. ÜA/HDL-K oranları iki grup arasında karşılaştırıldı. Bulgular: ÜA/HDL-K oranları, kötü KKD’si olan hastalarda, iyi KKD’si olan hastalarla karşılaştırıldığında anlamlı olarak daha yüksekti (0,18 [0,06- 0,49] vs 0,14 [0,05-0,31], sırasıyla; p<0,001). Korelasyon analizinde, KKD, ÜA/HDL-K ve ÜA seviyeleri ile anlamlı bir negatif korelasyon gösterdi (r=- 0,333, p<0,001; r=-0,502, p<0,001, sırasıyla). ROC analizinde, ÜA/HDL-K oranı için > 0,17’lik bir kesme değeri, %54,3 duyarlılık ve %79,3 özgüllük ile zayıf kollateral gelişimini öngördü (AUC=0,711, 95% CI 0,617–0,794, p<0,001). Çok değişkenli regresyon analizinde, serum ÜA kötü kollateral gelişiminin bağımsız bir prediktörü olarak bulundu (OR=2,818, p=0,022). Sonuç: Bu çalışma göstermiştir ki, ÜA/HDL-K oranı zayıf kollateral gelişimi ile ilişkili olabilse de, serum ÜA seviyeleri, KTO’lu hastalarda ÜA/HDL-K oranla rından kötü KKD’nin daha iyi bir öngördürücüsü olarak görünmektedir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Kalkan M, Sahin M, Kalkan A, Guler A, Tas M, Bulut M, et al. The relationship between the neutrophil-lymphocyte ratio and the coronary collateral circulation in patients with chronic total occlusion. Perfusion 2014;29(4):360-6.
2. Kurtul A, Duran M. The correlation between lymphocyte/monocyte ratio and coronary collateral circulation in stable coronary artery disease patients. Biomark Med 2017;11(1):43-52.
3. Nacar AB, Erayman A, Kurt M, Buyukkaya E, Karakas MF, Akcay AB, et al. The relationship between coronary collateral circulation and neutrophil/lymphocyte ratio in patients with coronary chronic total occlusion. Med Princ Pract 2015;24(1):65-9.
4. Hein TW, Singh U, Vasquez-Vivar J, Devaraj S, Kuo L, Jialal I. Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo. Atherosclerosis 2009;206(1):61-8.
5. Teixeira BC, Lopes AL, Macedo RCO, Correa CS, Ramis TR, Ribeiro JL, et al. Inflammatory markers, endothelial function and cardiovascular risk. J Vasc Bras 2014;13:108-15.
6. Hakimzadeh N, Verberne HJ, Siebes M, Piek JJ. The future of collateral artery research. Curr Cardiol Rev 2014;10(1):73-86.
7. El Ridi R, Tallima H. Physiological functions and pathogenic potential of uric acid: A review. J Adv Res 2017;8(5):487-93.
8. Saito Y, Tanaka A, Node K, Kobayashi Y. Uric acid and cardiovascular disease: A clinical review. J Cardiol 2021;78(1):51-7.
9. Yu W, Cheng JD. Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective. Front Pharmacol 2020;11:582680.
10. Liu GY, Meng XX, Zhang Z. Triglyceride to HDL-cholesterol ratio as an independent risk factor for the poor development of coronary collateral circulation in elderly patients with ST segment elevation myocardial infarction and acute total occlusion Medicine (Baltimore) 2018;97(39):e12587. doi: 10.1097/ MD.0000000000012587
11. Monette JS, Hutchins PM, Ronsein GE, Wimberger J, Irwin AD, Tang C, et al. Patients with coronary endothelial dysfunction have impaired cholesterol efflux capacity and reduced HDL particle concentration. Circ Res 2016;119(1):83-90.
12. Catapano AL, Graham I, De Backer G, Wiklund O, Chapman MJ, Drexel H, et al. 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. Eur Heart J 2016;37(39):2999-3058.
13. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51(3):606.
14. Rentrop KP, Cohen M, Blanke H, Phillips RA. Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects. J Am Coll Cardiol 1985;5(3):587-92.
15. Sharaf El Din UAA, Salem MM, Abdulazim DO. Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review. J Adv Res 2017;8(5):537-48.
16. Mandurino-Mirizzi A, Crimi G, Raineri C, Pica S, Ruffinazzi M, Gianni U, et al. Elevated serum uric acid affects myocardial reperfusion and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. J Cardiovasc Med (Hagerstown) 2018;19(5):240-6.
17. Katsiki N, Dimitriadis GD, Mikhailidis DP. Serum uric acid and diabetes: from pathophysiology to cardiovascular disease. Curr Pharm Des 2021;27(16):1941-51.
18. Borghi C, Rodriguez-Artalejo F, De Backer G, Dallongeville J, Medina J, Nuevo J, et al. Serum uric acid levels are associated with cardiovascular risk score: A post hoc analysis of the EURIKA study. Int J Cardiol 2018;253:167-73.
19. Wang Y, Zhang XY, Gao WH, Du MF, Chu C, Wang D, et al. Association of uric acid in serum and urine with arterial stiffness: Hanzhong Adolescent Hypertension Study. Dis Markers 2020;2020:1638515.
20. Aydın C, Emlek N. The relationship between uric acid to high density lipoprotein cholesterol ratio and collateral index in patients with chronic total occlusion. Kardiologiia 2021;61(9):61-5.
21. Schaper W, Sharma HS, Quinkler W, Markert T, Wünsch M, Schaper J. Molecular biologic concepts of coronary anastomoses. J Am Coll Cardiol 1990;15(3):513-8.
22. Chen X, Lin Y, Tian L, Wang Z. Correlation between ischemia modified albumin level and coronary collateral circulation. BMC Cardiovasc Disord 2020;20(1):326.
23. Akbuga K, Ferik O K, Yayla KG, Aslan T, Eren M, Karanfil M, et al. Prognostic nutritional index as a new prediction tool for coronary collateral development. Acta Cardiol Sin 2022;38(1):21-6.
24. Acar G, Kalkan ME, Avci A, Alizade E, Tabakci MM, Toprak C, et al. The relation of platelet-lymphocyte ratio and coronary collateral circulation in patients with stable angina pectoris and chronic total occlusion. Clin Appl Thromb Hemost 2015;21(5):462-8.
25. Kasapkara HA, Topsakal R, Yarlioglues M, Yarlioglues G, Dogdu O, Ardic I, et al. Effects of serum uric acid levels on coronary collateral circulation in patients with non-ST elevation acute coronary syndrome. Coron Artery Dis 2012;23(7):421-5.
26. Uysal OK, Sahin DY, Duran M, Turkoglu C, Yildirim A, Elbasan Z, et al. Association between uric acid and coronary collateral circulation in patients with stable coronary artery disease. Angiology 2014;65(3):227-31.
27. Wan GX, Xia WB, Ji LH, Qin HL, Zhang YG. Triglyceride to high density lipoprotein cholesterol ratio may serve as a useful predictor of major adverse coronary event in female revascularized ST-elevation myocardial infarction. Clin Chim Acta 2018;485:166- 72.
28. Lüscher TF, Tanner FC, Noll G. Lipids and endothelial function: effects of lipid-lowering and other therapeutic interventions. Curr Opin Lipidol 1996;7(4):234-40.
29. Liu R, Peng Y, Wu H, Diao X, Ye H, Huang X, et al. Uric acid to high-density lipoprotein cholesterol ratio predicts cardiovascular mortality in patients on peritoneal dialysis. Nutr Metab Cardiovasc Dis 2021;31(2):561-9.
30. Kocak MZ, Aktas G, Erkus E, Sincer I, Atak B, Duman T. Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus. Rev Assoc Med Bras (1992) 2019;65(1):9-15.
31. Ganjali S, Gotto AM, Jr., Ruscica M, Atkin SL, Butler AE, Banach M, et al. Monocyte-to-HDL-cholesterol ratio as a prognostic marker in cardiovascular diseases. J Cell Physiol 2018;233(12):9237-46.
32. Jiang M, Yang J, Zou H, Li M, Sun W, Kong X. Monocyte-to-high density lipoprotein-cholesterol ratio (MHR) and the risk of all-cause and cardiovascular mortality: a nationwide cohort study in the United States. Lipids Health Dis 2022;21(1):30.
33. Pohl T, Seiler C, Billinger M, Herren E, Wustmann K, Mehta H, et al. Frequency distribution of collateral flow and factors influencing collateral channel development. Functional collateral channel measurement in 450 patients with coronary artery disease. J Am Coll Cardiol 2001;38(7):1872-8.

APA	BAYKIZ D, Demirtakan Z, Ayduk Gövdeli E, Emet S, Elitok A (2023). COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. , 1 - 9. 10.26650/JARHS2023-1199242
Chicago	BAYKIZ DERYA,Demirtakan Zeynep Gizem,Ayduk Gövdeli Elif,Emet Samim,Elitok Ali COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. (2023): 1 - 9. 10.26650/JARHS2023-1199242
MLA	BAYKIZ DERYA,Demirtakan Zeynep Gizem,Ayduk Gövdeli Elif,Emet Samim,Elitok Ali COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. , 2023, ss.1 - 9. 10.26650/JARHS2023-1199242
AMA	BAYKIZ D,Demirtakan Z,Ayduk Gövdeli E,Emet S,Elitok A COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. . 2023; 1 - 9. 10.26650/JARHS2023-1199242
Vancouver	BAYKIZ D,Demirtakan Z,Ayduk Gövdeli E,Emet S,Elitok A COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. . 2023; 1 - 9. 10.26650/JARHS2023-1199242
IEEE	BAYKIZ D,Demirtakan Z,Ayduk Gövdeli E,Emet S,Elitok A "COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION." , ss.1 - 9, 2023. 10.26650/JARHS2023-1199242
ISNAD	BAYKIZ, DERYA vd. "COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION". (2023), 1-9. https://doi.org/10.26650/JARHS2023-1199242

APA	BAYKIZ D, Demirtakan Z, Ayduk Gövdeli E, Emet S, Elitok A (2023). COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. Sabiad , 6(1), 1 - 9. 10.26650/JARHS2023-1199242
Chicago	BAYKIZ DERYA,Demirtakan Zeynep Gizem,Ayduk Gövdeli Elif,Emet Samim,Elitok Ali COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. Sabiad 6, no.1 (2023): 1 - 9. 10.26650/JARHS2023-1199242
MLA	BAYKIZ DERYA,Demirtakan Zeynep Gizem,Ayduk Gövdeli Elif,Emet Samim,Elitok Ali COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. Sabiad , vol.6, no.1, 2023, ss.1 - 9. 10.26650/JARHS2023-1199242
AMA	BAYKIZ D,Demirtakan Z,Ayduk Gövdeli E,Emet S,Elitok A COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. Sabiad . 2023; 6(1): 1 - 9. 10.26650/JARHS2023-1199242
Vancouver	BAYKIZ D,Demirtakan Z,Ayduk Gövdeli E,Emet S,Elitok A COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. Sabiad . 2023; 6(1): 1 - 9. 10.26650/JARHS2023-1199242
IEEE	BAYKIZ D,Demirtakan Z,Ayduk Gövdeli E,Emet S,Elitok A "COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION." Sabiad , 6, ss.1 - 9, 2023. 10.26650/JARHS2023-1199242
ISNAD	BAYKIZ, DERYA vd. "COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION". Sabiad 6/1 (2023), 1-9. https://doi.org/10.26650/JARHS2023-1199242