TY  - JOUR
TI  - COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN  CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON  CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH  CHRONIC TOTAL OCCLUSION
AB  - Objective: Coronary collateral circulation (CCC) plays a significant role in  cardiovascular prognosis, and well-developed CCC improves survival. The  aim of this study was to investigate whether the serum uric acid to high density lipoprotein cholesterol ratio (UA/HDL-C) is associated with  coronary collateral development. Materials and Methods: This retrospective study enrolled 111 patients  with stable coronary artery disease and at least one chronic total  occlusion (CTO) at invasive coronary angiography. Blood samples were  obtained from all patients before the angiography procedure. The  collateral degree was determined according to the Rentrop scoring  system. Patients were classified into a poor CCC group (Rentrop grades  0-1, n=47) or a good CCC group (Rentrop grades 2-3, n=64). The UA/HDL-C  ratios were compared between the two groups. Results: The UA/HDL-C ratios were significantly higher in patients with  poor CCC compared with the patients with good CCC (0.18 [0.06-0.49] vs 0.14 [0.05-0.31], respectively; p<0.001). In correlation analysis, the CCC  was significantly negatively correlated with UA/HDL-C and UA levels (r=- 0.333, p<0.001; r=-0.502, p<0.001, respectively). According to the ROC  analysis, a cut-off value of > 0.17 for the UA/HDL-C ratio predicted poor  collateral development with 54.3% sensitivity and 79.3% specificity  (AUC=0.711, 95% CI 0.617–0.794, p<0.001). In multivariate regression  analysis, serum UA was found to be an independent predictor of poor  collateral development (OR=2.818, p=0.022). Conclusion: The present study showed that although the UA/HDL-C ratio may  be associated with poor collateral development, serum UA levels seem to be  a better predictor of poor CCC than UA/HDL-C ratios in patients with CTO.
AU  - Ayduk Gövdeli, Elif
AU  - Emet, Samim
AU  - Elitok, Ali
AU  - BAYKIZ, DERYA
AU  - Demirtakan, Zeynep Gizem
DO  - 10.26650/JARHS2023-1199242
PY  - 2023
JO  - Sabiad 
VL  - 6
IS  - 1
SN  - 2651-4060
SP  - 1
EP  - 9
DB  - TRDizin
UR  - http://search/yayin/detay/1166771
ER  -