Relationship between Juvenile Myoclonic Epilepsy and Melatonin

GENÇ, BÜLENT OGUZ; Altaş, Mustafa; KILINC, Ibrahim; Akyol, Asli

doi:10.30733/std.2023.01575

Relationship between Juvenile Myoclonic Epilepsy and Melatonin

Mustafa ATLAS, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Tıp Anabilim Dalı Nöroloji, Konya, Türkiye)

Bulent Oguz GENC, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Tıp Anabilim Dalı Nöroloji, Konya, Türkiye)

İbrahim KILINÇ, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Tıp Anabilim Dalı Biyokimya, Konya, Türkiye)

Asli Akyol GURSES (Gazi Üniversitesi Tıp Fakültesi, Nöroloji Bölümü (Klinik Bölümü Nörofizyoloji), Ankara, Türkiye)

Selçuk Tıp Dergisi

24 3

Yıl: 2023 Cilt: 39 Sayı: 1 Sayfa Aralığı: 35 - 40 Metin Dili: İngilizce DOI: 10.30733/std.2023.01575 İndeks Tarihi: 05-05-2023

Relationship between Juvenile Myoclonic Epilepsy and Melatonin

Öz:

Aim: Melatonin has been found to have anticonvulsant and neuroprotective properties by regulating the circadian rhythm. Based on this effect, it was aimed to determine the serum levels of melatonin in patients with juvenile myoclonic epilepsy (JME) and healthy individuals. It is also the first study to compare serum melatonin levels in patients with JME and healthy individuals. Patients and Methods: Thirty patients with JME and 30 healthy controls with similar gender and age distribution were included in this cross-sectional study. Venous blood samples were taken from patients with JME and healthy individuals to determine the peak serum melatonin level at night and the lowest serum melatonin level in the morning, and studied with the ELIS A method. Results: Compared to healthy controls, serum MELn (p = 0.002) and MELm (p = 0.001) levels of JME patients were determined to be lower than healthy controls. Moreover, there were statistically significant differences between MELn/MELm ratio and MELn-MELm difference between patients with JME and the control group (p = 0.005 and 0.014, respectively). Conclusion: The results show that the circadian rhythm of melatonin is preserved in the patients with JME and the control group, but the serum melatonin levels in the patients are lower than in the controls. Therefore, the determination of melatonin level in patients with JME may contribute to both the determination of the etiology of the disease and the prevention of unnecessary and high-dose antiepileptic drug use by supplementing with melatonin when necessary .

Anahtar Kelime:

Juvenil Miyoklonik Epilepsi ve Melatonin İlişkisi

Öz:

Amaç: Melatoninin sirkadiyen ritmi düzenleyerek antikonvülsan ve nöroprotektif özelliklere sahip olduğu bulunmuştur. Bu etkisinden yola çıkarak Juvenil myoklonik epilepsili (JME) hastalar ve sağlıklı bireylerde melatonin serum düzeylerinin belirlenmesi amaçlanmıştır. JME’li hastalar ile sağlıklı bireylerdeki serum melatonin seviyelerini karşılaştıran ilk çalışma olma özelliğin i de taşımaktadır . Hastalar ve Yöntem: Bu çapraz-kesitsel çalışmaya JME’li 30 hasta ve benzer cinsiyet ve yaş dağılımına sahip 30 sağlıklı kontrol dahil edildi. JME’li hastalar ve sağlıklı bireylerden, gece meydana gelen serum melatonin pik düzeyini ve sabahki en düşük serum melatonin düzeyini belirlemek üzere venöz kan örnekleri alınarak ELISA yöntemiyle çalışıldı. Bulgular: Sağlıklı kontrollere kıyasla JME'li hastaların serum MELn (p = 0,002) ve MELm (p = 0,001) düzeyi daha düşük tespit edildi. Ayrıca JME’li hastalar ve kontrol grubu arasında MELn/MELm oranı ve MELn-MELm farkı açısından istatistiksel olarak anlamlı farklılıklar vardı (sırasıyla p = 0,005 ve 0,014). Sonuç: Elde edilen sonuçlar JME’li hastalar ve kontrol grubunda melatoninin sirkadien ritminin korunduğunu fakat hastalarda serum melatonin düzeylerinin kontrollere göre düşük seyrettiğini göstermektedir. Bundan dolayı JME’li hastalarda melatonin düzeyinin tespiti hem hastalık etyolojisinin belirlenmesine hem de gerektiğinde melatonin takviyesi yapılması ile gereksiz ve yüksek doz antiepileptik ilaç kullanımının engellenmesine katkı sağlayabilir .

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Altaş M, GENÇ B, KILINC I, Akyol A (2023). Relationship between Juvenile Myoclonic Epilepsy and Melatonin. , 35 - 40. 10.30733/std.2023.01575
Chicago	Altaş Mustafa,GENÇ BÜLENT OGUZ,KILINC Ibrahim,Akyol Asli Relationship between Juvenile Myoclonic Epilepsy and Melatonin. (2023): 35 - 40. 10.30733/std.2023.01575
MLA	Altaş Mustafa,GENÇ BÜLENT OGUZ,KILINC Ibrahim,Akyol Asli Relationship between Juvenile Myoclonic Epilepsy and Melatonin. , 2023, ss.35 - 40. 10.30733/std.2023.01575
AMA	Altaş M,GENÇ B,KILINC I,Akyol A Relationship between Juvenile Myoclonic Epilepsy and Melatonin. . 2023; 35 - 40. 10.30733/std.2023.01575
Vancouver	Altaş M,GENÇ B,KILINC I,Akyol A Relationship between Juvenile Myoclonic Epilepsy and Melatonin. . 2023; 35 - 40. 10.30733/std.2023.01575
IEEE	Altaş M,GENÇ B,KILINC I,Akyol A "Relationship between Juvenile Myoclonic Epilepsy and Melatonin." , ss.35 - 40, 2023. 10.30733/std.2023.01575
ISNAD	Altaş, Mustafa vd. "Relationship between Juvenile Myoclonic Epilepsy and Melatonin". (2023), 35-40. https://doi.org/10.30733/std.2023.01575

APA	Altaş M, GENÇ B, KILINC I, Akyol A (2023). Relationship between Juvenile Myoclonic Epilepsy and Melatonin. Selçuk Tıp Dergisi, 39(1), 35 - 40. 10.30733/std.2023.01575
Chicago	Altaş Mustafa,GENÇ BÜLENT OGUZ,KILINC Ibrahim,Akyol Asli Relationship between Juvenile Myoclonic Epilepsy and Melatonin. Selçuk Tıp Dergisi 39, no.1 (2023): 35 - 40. 10.30733/std.2023.01575
MLA	Altaş Mustafa,GENÇ BÜLENT OGUZ,KILINC Ibrahim,Akyol Asli Relationship between Juvenile Myoclonic Epilepsy and Melatonin. Selçuk Tıp Dergisi, vol.39, no.1, 2023, ss.35 - 40. 10.30733/std.2023.01575
AMA	Altaş M,GENÇ B,KILINC I,Akyol A Relationship between Juvenile Myoclonic Epilepsy and Melatonin. Selçuk Tıp Dergisi. 2023; 39(1): 35 - 40. 10.30733/std.2023.01575
Vancouver	Altaş M,GENÇ B,KILINC I,Akyol A Relationship between Juvenile Myoclonic Epilepsy and Melatonin. Selçuk Tıp Dergisi. 2023; 39(1): 35 - 40. 10.30733/std.2023.01575
IEEE	Altaş M,GENÇ B,KILINC I,Akyol A "Relationship between Juvenile Myoclonic Epilepsy and Melatonin." Selçuk Tıp Dergisi, 39, ss.35 - 40, 2023. 10.30733/std.2023.01575
ISNAD	Altaş, Mustafa vd. "Relationship between Juvenile Myoclonic Epilepsy and Melatonin". Selçuk Tıp Dergisi 39/1 (2023), 35-40. https://doi.org/10.30733/std.2023.01575