Yıl: 2022 Cilt: 60 Sayı: 2 Sayfa Aralığı: 72 - 79 Metin Dili: İngilizce DOI: 10.4274/tao.2022.2022-4-1 İndeks Tarihi: 06-05-2023

Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients

Öz:
Objective: The purpose of this study was to evaluate the functional and oncological outcomes of total glossectomy with laryngeal preservation (TGLP) compared to near-total glossectomy with laryngeal preservation (nTGLP). Methods: In this retrospective study, the data of 23 patients who underwent either TGLP or nTGLP between January 2010 and December 2020 in a tertiary university hospital were analyzed. The data including demographic findings, tumor stage, extent of surgery and technique, method of reconstruction, complications, overall survival (OS) and recurrence-free survival (RFS), and tracheostomy and gastric tube dependence during follow-up were assessed. Results: Of the 23 eligible patients, 15 had undergone nTGLP (Group 1) and 8 had undergone TGLP (Group 2).Tracheostomy dependence and gastric tube dependence rates at the sixth month were 3/19 (15.7%) and 12/19 (63.1%), respectively, with no significant differences between the two groups. OS and RFS at one year were 47.6% and 27.8%, respectively, for the study population. OS rate showed significance with nodal positivity and extranodal extension (p=0.004 for both) only, but not within patient groups (p=0.734). Conclusion: Both TGLP and nTGLP are feasible treatment options in patients with advanced tongue cancer with no differences in terms of functional and oncological results. Survival rates are still not satisfactory, and recurrences are high despite appropriate treatments. Proper selection of patients who are highly motivated and willing for long-term postoperative rehabilitation is essential.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Mazarro A, de Pablo A, Puiggròs C, Velasco MM, Saez M, Pamias J, et al. Indications, reconstructive techniques, and results for total glossectomy. Head Neck 2016; 38 Suppl 1: E2004-10.
  • Keski-Säntti H,Bäck L,Lassus P,Koivunen P,Kinnunen I,Blomster H, et al. Total or subtotal glossectomy with laryngeal preservation: a national study of 29 patients. Eur Arch Otorhinolaryngol 2018; 275: 191-7.
  • Gehanno P, Guedon C, Barry B, Depondt J, Kebaili C. Advanced carcinoma of the tongue: total glossectomy without total laryngectomy. Review of 80 cases. Laryngoscope 1992; 102: 1369- 71.
  • Barry B, Baujat B, Albert S, Nallet E, Depondt J, Guedon C, et al. Total glossectomy without laryngectomy as first-line or salvage therapy. Laryngoscope 2003; 113: 373-6.
  • Rihani J, Lee MR, Lee T, Ducic Y. Flap selection and functional outcomes in total glossectomy with laryngeal preservation. Otolaryngol Head Neck Surg 2013; 149: 547-53.
  • Dziegielewski PT, Ho ML, Rieger J, Singh P, Langille M, Harris JR, et al. Total glossectomy with laryngeal preservation and free flap reconstruction: objective functional outcomes and systematic review of the literature. Laryngoscope 2013; 123: 140-5.
  • Han AY, Kuan EC, Mallen-St Clair J, Badran KW, Palma Diaz MF, Blackwell KE, et al. Total glossectomy with free flap reconstruction: twenty-year experience at a tertiary medical center. Laryngoscope 2019; 129: 1087-92.
  • Lin DT, Yarlagadda BB, Sethi RK, Feng AL, Shnayder Y, Ledgerwood LG, et al. Long-term functional outcomes of total glossectomy with or without total laryngectomy. JAMA Otolaryngol Head Neck Surg 2015; 141: 797-803.
  • Reiter M, Harréus U. Total glossectomy without laryngectomy for advanced squamous cell cancer of the tongue: functional and oncological results. Anticancer Res 2017; 37: 4233-7.
  • Navach V, Zurlo V, Calabrese L, Massaro MA, Bruschini R, Giugliano G, et al. Total glossectomy with preservation of the larynx: oncological and functional results. Br J Oral Maxillofac Surg 2013; 51: 217-23.
  • Rigby MH, Hayden RE. Total glossectomy without laryngectomy - a review of functional outcomes and reconstructive principles. Curr Opin Otolaryngol Head Neck Surg 2014; 22: 414-8.
  • Sinclair CF, Carroll WR, Desmond RA, Rosenthal EL. Functional and survival outcomes in patients undergoing total glossectomy compared with total laryngoglossectomy. Otolaryngol Head Neck Surg 2011; 145: 755-8.
  • Ansarin M, Bruschini R, Navach V, Giugliano G, Calabrese L, Chiesa F, et al. Classification of GLOSSECTOMIES: proposal for tongue cancer resections. Head Neck 2019; 41: 821-7.
APA Demir U, Aslıer M, inan c (2022). Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients. , 72 - 79. 10.4274/tao.2022.2022-4-1
Chicago Demir Uygar Levent,Aslıer Mustafa,inan caner Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients. (2022): 72 - 79. 10.4274/tao.2022.2022-4-1
MLA Demir Uygar Levent,Aslıer Mustafa,inan caner Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients. , 2022, ss.72 - 79. 10.4274/tao.2022.2022-4-1
AMA Demir U,Aslıer M,inan c Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients. . 2022; 72 - 79. 10.4274/tao.2022.2022-4-1
Vancouver Demir U,Aslıer M,inan c Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients. . 2022; 72 - 79. 10.4274/tao.2022.2022-4-1
IEEE Demir U,Aslıer M,inan c "Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients." , ss.72 - 79, 2022. 10.4274/tao.2022.2022-4-1
ISNAD Demir, Uygar Levent vd. "Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients". (2022), 72-79. https://doi.org/10.4274/tao.2022.2022-4-1
APA Demir U, Aslıer M, inan c (2022). Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients. Turkish archives of otorhinolaryngology , 60(2), 72 - 79. 10.4274/tao.2022.2022-4-1
Chicago Demir Uygar Levent,Aslıer Mustafa,inan caner Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients. Turkish archives of otorhinolaryngology 60, no.2 (2022): 72 - 79. 10.4274/tao.2022.2022-4-1
MLA Demir Uygar Levent,Aslıer Mustafa,inan caner Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients. Turkish archives of otorhinolaryngology , vol.60, no.2, 2022, ss.72 - 79. 10.4274/tao.2022.2022-4-1
AMA Demir U,Aslıer M,inan c Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients. Turkish archives of otorhinolaryngology . 2022; 60(2): 72 - 79. 10.4274/tao.2022.2022-4-1
Vancouver Demir U,Aslıer M,inan c Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients. Turkish archives of otorhinolaryngology . 2022; 60(2): 72 - 79. 10.4274/tao.2022.2022-4-1
IEEE Demir U,Aslıer M,inan c "Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients." Turkish archives of otorhinolaryngology , 60, ss.72 - 79, 2022. 10.4274/tao.2022.2022-4-1
ISNAD Demir, Uygar Levent vd. "Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients". Turkish archives of otorhinolaryngology 60/2 (2022), 72-79. https://doi.org/10.4274/tao.2022.2022-4-1