Objective: This study was conducted to determine the problems experienced by patients with urostomy due to leakage and the methods of coping with these problems. Material and Methods: The convenient sampling method, one of the non-probability-based purposive sampling techniques, was used in the study. The study group of the study consisted of adult patients with urostomy who were admitted to the urology clinic of a university hospital for any reason, had leakage problems, and agreed to interview. Research data were collected through semi-structured interviews between June 2021 and January 2022. The content analysis method was used in the analysis of the data. Results: The sample of the study consisted of 10 patients with urostomy, aged between 48 and 74, who had leakage problems. It was determined that the majority of the patients did not receive sufficient information about urostomy care before and their family members formed their social support systems. The problems experienced by the patients due to leakage are divided into two themes as physiological and psychological. It has been determined that the problems experienced by patients with urostomy due to leakage are mostly psychological. It has been determined that patients with urostomy experience the most physical irritation problem and the most common psychological distress. The methods of coping with leakage of patients with urostomy are also divided into two themes, physical and psychological methods, in parallel with the problems they experience. It was determined that the patients most frequently used barrier-purpose stoma paste to cope with physical problems, and they chose the method of accepting the situation in coping with psychological problems. Conclusion: It was concluded that patients with urostomy experience both physiological and psychological problems due to leakage and use various physical and psychological methods to cope with leakage.