Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit

korkmaz, safak; GURELIK, GOKHAN; Uyar Gocun, Pinar; sul, sabahattin

doi:10.37845/ret.vit.2022.31.66

Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit

Gökhan GÜRELİK, (Göz Hastalıkları Gazi Üniversitesi Tıp Fakültesi, Ankara, Türkiye)

safak korkmaz, (Göz Hastalıkları, Giresun Üniversitesi Tıp Fakültesi, Giresun, Türkiye)

Pinar UYAR GOCUN, (Göz Hastalıkları Gazi Üniversitesi Tıp Fakültesi, Ankara, Türkiye)

Sabahattin SÜL (Patoloji, Gazi Üniversitesi Tıp Fakültesi, Ankara, Türkiye)

Retina-Vitreus

4 0

Yıl: 2022 Cilt: 31 Sayı: 4 Sayfa Aralığı: 387 - 396 Metin Dili: İngilizce DOI: 10.37845/ret.vit.2022.31.66 İndeks Tarihi: 07-05-2023

Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit

Öz:

Purpose: To evaluate the safety of a new intraocular mitomycin c (MMC) application technique in the rabbits. Materials and Methods: Sixteen male New Zealand rabbits were used. The rabbits were divided into 4 study groups. 2μg MMC in group-A, 5μg MMC in group-B, 10μg MMC in group-C and 20 μg MMC in group-D were applied with MMC sandwich technique into right eyes of rabbits. In MMC sandwich technique, ciliary body was protected with air, and posterior pole was protected with perfluorocarbon. The left eye was used as a control group. The rabbits had one-month followed up. Intraocular pressures were measured at first week and month 1. Scotopic and photopic a- and b-wave amplitudes and implicit times were compared between control and study eyes. Multiple small slices that included the ciliary body, macula and optic nerve head were examined for the evaluation of MMC toxicity Results: Intraocular pressure did not differ between the control and study eyes. Scotopic and photopic a- and b-wave amplitudes and implicit times of group A, B, C and D eyes were similar to those of the control eyes. In all of the study groups, the histopatholologic morphologies of the ciliary body, retina and optic nerve were similar to those of control group. Furthermore, retinal layer thicknesses were similar between the MMC injected eyes and the control eyes. Conclusions: Our newly defined MMC sandwich technique permitted the use of MMC up to 20 μg concentrations without causing toxicity in the vital intraocular structures.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

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APA	GURELIK G, korkmaz s, Uyar Gocun P, sul s (2022). Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit. , 387 - 396. 10.37845/ret.vit.2022.31.66
Chicago	GURELIK GOKHAN,korkmaz safak,Uyar Gocun Pinar,sul sabahattin Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit. (2022): 387 - 396. 10.37845/ret.vit.2022.31.66
MLA	GURELIK GOKHAN,korkmaz safak,Uyar Gocun Pinar,sul sabahattin Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit. , 2022, ss.387 - 396. 10.37845/ret.vit.2022.31.66
AMA	GURELIK G,korkmaz s,Uyar Gocun P,sul s Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit. . 2022; 387 - 396. 10.37845/ret.vit.2022.31.66
Vancouver	GURELIK G,korkmaz s,Uyar Gocun P,sul s Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit. . 2022; 387 - 396. 10.37845/ret.vit.2022.31.66
IEEE	GURELIK G,korkmaz s,Uyar Gocun P,sul s "Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit." , ss.387 - 396, 2022. 10.37845/ret.vit.2022.31.66
ISNAD	GURELIK, GOKHAN vd. "Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit". (2022), 387-396. https://doi.org/10.37845/ret.vit.2022.31.66

APA	GURELIK G, korkmaz s, Uyar Gocun P, sul s (2022). Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit. Retina-Vitreus, 31(4), 387 - 396. 10.37845/ret.vit.2022.31.66
Chicago	GURELIK GOKHAN,korkmaz safak,Uyar Gocun Pinar,sul sabahattin Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit. Retina-Vitreus 31, no.4 (2022): 387 - 396. 10.37845/ret.vit.2022.31.66
MLA	GURELIK GOKHAN,korkmaz safak,Uyar Gocun Pinar,sul sabahattin Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit. Retina-Vitreus, vol.31, no.4, 2022, ss.387 - 396. 10.37845/ret.vit.2022.31.66
AMA	GURELIK G,korkmaz s,Uyar Gocun P,sul s Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit. Retina-Vitreus. 2022; 31(4): 387 - 396. 10.37845/ret.vit.2022.31.66
Vancouver	GURELIK G,korkmaz s,Uyar Gocun P,sul s Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit. Retina-Vitreus. 2022; 31(4): 387 - 396. 10.37845/ret.vit.2022.31.66
IEEE	GURELIK G,korkmaz s,Uyar Gocun P,sul s "Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit." Retina-Vitreus, 31, ss.387 - 396, 2022. 10.37845/ret.vit.2022.31.66
ISNAD	GURELIK, GOKHAN vd. "Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit". Retina-Vitreus 31/4 (2022), 387-396. https://doi.org/10.37845/ret.vit.2022.31.66