TY  - JOUR
TI  - Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit
AB  - Purpose: To evaluate the safety of a new intraocular mitomycin c (MMC) application technique in the rabbits. Materials and Methods: Sixteen male New Zealand rabbits were used. The rabbits were divided into 4 study groups. 2μg MMC in group-A, 5μg MMC in group-B, 10μg MMC in group-C and 20 μg MMC in group-D were applied with MMC sandwich technique into right eyes of rabbits. In MMC sandwich technique, ciliary body was protected with air, and posterior pole was protected with perfluorocarbon. The left eye was used as a control group. The rabbits had one-month followed up. Intraocular pressures were measured at first week and month 1. Scotopic and photopic a- and b-wave amplitudes and implicit times were compared between control and study eyes. Multiple small slices that included the ciliary body, macula and optic nerve head were examined for the evaluation of MMC toxicity Results: Intraocular pressure did not differ between the control and study eyes. Scotopic and photopic a- and b-wave amplitudes and implicit times of group A, B, C and D eyes were similar to those of the control eyes. In all of the study groups, the histopatholologic morphologies of the ciliary body, retina and optic nerve were similar to those of control group. Furthermore, retinal layer thicknesses were similar between the MMC injected eyes and the control eyes. Conclusions: Our newly defined MMC sandwich technique permitted the use of MMC up to 20 μg concentrations without causing toxicity in the vital intraocular structures.
AU  - korkmaz, safak
AU  - GURELIK, GOKHAN
AU  - Uyar Gocun, Pinar
AU  - sul, sabahattin
DO  - 10.37845/ret.vit.2022.31.66
PY  - 2022
JO  - Retina-Vitreus
VL  - 31
IS  - 4
SN  - 1300-1256
SP  - 387
EP  - 396
DB  - TRDizin
UR  - http://search/yayin/detay/1167690
ER  -