Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia

Ulas, Turgay; Doğan, Ali; Demircioğlu, Sinan; Ekinci, Omer

doi:10.14235/bas.galenos.2021.5875

Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia

Sinan DEMİRCİOĞLU, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Hematoloji Anabilim Dalı, Konya, TÜRKİYE)

Omer EKINCI, (Fırat Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Elazığ, TÜRKİYE)

Ali DOGAN, (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Van, TÜRKİYE)

Turgay ULAS (Yakın Doğu University, Faculty of Medicine, Department of Hematology, Lefkoşa, Northern Cyprus)

Bezmiâlem Science

5 1

Yıl: 2022 Cilt: 10 Sayı: 4 Sayfa Aralığı: 402 - 408 Metin Dili: İngilizce DOI: 10.14235/bas.galenos.2021.5875 İndeks Tarihi: 08-05-2023

Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia

Öz:

Objective: Chromosomal abnormalities are one of the most important prognostic factors in acute myeloid leukemia (AML). However, not all patients may have such informative chromosomal abnormalities. Although there are many studies on the prognostic value of immunophenotyping in AML, it is still not used as a prognostic marker. In this study, we aimed to investigate the effects of CD13, CD33, CD34, CD117, MPO and HLADR expressions on prognosis of non-acute promyelocytic leukemia AML. Methods: One hundred thirteen patients diagnosed as having non- acute promyelocytic leukemia AML and followed up between 2010 and 2018 were included in this study. The associations of CD13, CD33, CD34, CD117, MPO and HLA DR expressions with chemotherapy response, progression free survival (PFS) and overall survival (OS) were statistically analyzed. Results: It was seen that response to chemotherapy was achieved in 67.3% of the patients. Median PFS duration was 9 months and median OS duration was found as 13 months. Of the immunophenotypic characteristics, only MPO expression was determined to be an independent risk factor for PFS and OS. Conclusion: Immunophenotypic features may be helpful in the diagnosis of AML as well as give an idea about prognosis. In this study, MPO expression was shown to be an independent risk factor for PFS and OS in our own patient population.

Anahtar Kelime:

Akut Miyeloid Lösemili Hastalarda Akış Sitometrik İmmünofenotiplemenin Prognostik Önemi

Öz:

Amaç: Kromozomal anormallikler, akut miyeloid lösemide (AML) en önemli prognostik faktörlerden biridir. Bununla birlikte, tüm hastalarda bu tür bilgilendirici kromozomal anormallikler olmayabilir. AML’de immünofenotiplemenin prognostik değeri üzerine birçok çalışma olmasına rağmen, immünofenotipleme halen prognostik belirteç olarak kullanılmamaktadır. Bu çalışmada akut promiyelositik lösemi dışı AML’de CD13, CD33, CD34, CD117, MPO ve HLADR ekspresyonlarının prognoz üzerindeki etkilerini araştırmayı amaçladık. Yöntemler: Bu çalışmaya 2010-2018 yılları arasında tanı konup tedavi edilen 113 akut promiyelositik lösemi dışı AML’li hasta dahil edilmiştir. CD13, CD33, CD34, CD117, MPO ve HLA DR ekspresyonlarının kemoterapi yanıtı ve progresyonsuz (PFS) ve genel sağkalım (OS) ile ilişkisi istatistiksel olarak analiz edildi. Bulgular: Hastaların %67,3’ünde kemoterapiye yanıt alındığı görüldü. Medyan PFS süresi 9 aydı ve medyan OS süresi 13 ay olarak bulundu. İmmünofenotipik özelliklerden yalnızca MPO ekspresyonunun, PFS ve OS için bağımsız bir risk faktörü olduğu belirlendi. Sonuç: İmmünofenotipik özellikler AML tanısında yardımcı olabileceği gibi prognoz hakkında da fikir verebilir. Bu çalışmada, MPO ekspresyonunun kendi hasta popülasyonumuzda PFS ve OS için bağımsız bir risk faktörü olduğu gösterilmiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Demircioğlu S, Ekinci O, Doğan A, Ulas T (2022). Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia. , 402 - 408. 10.14235/bas.galenos.2021.5875
Chicago	Demircioğlu Sinan,Ekinci Omer,Doğan Ali,Ulas Turgay Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia. (2022): 402 - 408. 10.14235/bas.galenos.2021.5875
MLA	Demircioğlu Sinan,Ekinci Omer,Doğan Ali,Ulas Turgay Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia. , 2022, ss.402 - 408. 10.14235/bas.galenos.2021.5875
AMA	Demircioğlu S,Ekinci O,Doğan A,Ulas T Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia. . 2022; 402 - 408. 10.14235/bas.galenos.2021.5875
Vancouver	Demircioğlu S,Ekinci O,Doğan A,Ulas T Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia. . 2022; 402 - 408. 10.14235/bas.galenos.2021.5875
IEEE	Demircioğlu S,Ekinci O,Doğan A,Ulas T "Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia." , ss.402 - 408, 2022. 10.14235/bas.galenos.2021.5875
ISNAD	Demircioğlu, Sinan vd. "Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia". (2022), 402-408. https://doi.org/10.14235/bas.galenos.2021.5875

APA	Demircioğlu S, Ekinci O, Doğan A, Ulas T (2022). Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia. Bezmiâlem Science, 10(4), 402 - 408. 10.14235/bas.galenos.2021.5875
Chicago	Demircioğlu Sinan,Ekinci Omer,Doğan Ali,Ulas Turgay Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia. Bezmiâlem Science 10, no.4 (2022): 402 - 408. 10.14235/bas.galenos.2021.5875
MLA	Demircioğlu Sinan,Ekinci Omer,Doğan Ali,Ulas Turgay Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia. Bezmiâlem Science, vol.10, no.4, 2022, ss.402 - 408. 10.14235/bas.galenos.2021.5875
AMA	Demircioğlu S,Ekinci O,Doğan A,Ulas T Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia. Bezmiâlem Science. 2022; 10(4): 402 - 408. 10.14235/bas.galenos.2021.5875
Vancouver	Demircioğlu S,Ekinci O,Doğan A,Ulas T Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia. Bezmiâlem Science. 2022; 10(4): 402 - 408. 10.14235/bas.galenos.2021.5875
IEEE	Demircioğlu S,Ekinci O,Doğan A,Ulas T "Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia." Bezmiâlem Science, 10, ss.402 - 408, 2022. 10.14235/bas.galenos.2021.5875
ISNAD	Demircioğlu, Sinan vd. "Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia". Bezmiâlem Science 10/4 (2022), 402-408. https://doi.org/10.14235/bas.galenos.2021.5875