MikroRNA’lar ve kanser

Değirmenci, İrfan; saydam, faruk; GÜNEŞ, HASAN VEYSİ

MikroRNA’lar ve kanser

Faruk SAYDAM, (Osmangazi Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Eskişehir, Türkiye)

İrfan DEĞİRMENCİ, (Osmangazi Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Eskişehir, Türkiye)

Hasan Veysi GÜNEŞ (Osmangazi Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Eskişehir, Türkiye)

Dicle Tıp Dergisi

16 4

Yıl: 2011 Cilt: 38 Sayı: 1 Sayfa Aralığı: 113 - 120 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

MikroRNA’lar ve kanser

Öz:

MikroRNA(miRNA)’lar, yüksek seviyede korunan DNA bölgelerinden kodlanan fakat proteine translasyonu gerçekleşmeyen, yaklaşık 18-24 nükleotid uzunluğunda, küçük RNA molekülleridir. Bu protein kodlamayan RNA molekülleri kendi nükleotid dizilerinin tamamlayıcısı olan hedef mRNA’lara bağlanıp translasyonel baskılama veya mRNA yıkımı ile transkripsiyon sonrası gen ekspresyonunun düzenlenmesini gerçekleştirirler. miRNA’lar bu yolağı kullanarak hücre proliferasyonu, hücre farklılaşması ve hücre ölümü gibi homeostatik süreçlerde önemli roller oynamaktadır. Yakın zamanda yapılan gen ekspresyon çalışmaları, kontrolsüz hücre bölünmesinin gerçekleştiği kanser hücrelerinde değişikliğe uğramış miRNA ekspresyonlarını gözler önüne sermiştir. Kanserin başlamasında ve ilerlemesinde, miRNA’lar hedefledikleri genin karakterine göre tümör süpresörler veya onkogenler gibi fonksiyon göstermektedirler. Bu derlemede miRNA oluşumu ve miRNA’ların kanser gelişimindeki rolleri anlatılmış olup, miRNA’ların kanser ile olan ilişkisini ortaya koyan çalışmalar gözden geçirilmiştir.

Anahtar Kelime:

Konular: Mikrobiyoloji Biyoteknoloji ve Uygulamalı Mikrobiyoloji Genetik ve Kalıtım

MicroRNAs and cancer

Öz:

MicroRNAs (MiRNAs) are highly conserved, non-protein-coding, approximately 18-24 nucleotides, small RNA molecules. These non-protein-coding RNAs bind target mRNAs which are complementary with their squences and post-transcriptionally regulate gene expression through translation repression or mRNA degradation. Using this pathway, miRNAs play important roles in homeostatic process including cell proliferation, differentiation and cell death. Recent studies based on gene expression have revealed that miRNA expressions are deregulated in cancer cells which have uncontrolled grow. According to character of target mRNA, miRNAs act like tumor supressor or oncogene in cancer initiation and progression. In this review, miRNA biogenesis and their roles in cancer progression are described and studies setting out the relationship between miRNAs and cancer are reviewed.

Anahtar Kelime:

Konular: Mikrobiyoloji Biyoteknoloji ve Uygulamalı Mikrobiyoloji Genetik ve Kalıtım

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	saydam f, Değirmenci İ, GÜNEŞ H (2011). MikroRNA’lar ve kanser. , 113 - 120.
Chicago	saydam faruk,Değirmenci İrfan,GÜNEŞ HASAN VEYSİ MikroRNA’lar ve kanser. (2011): 113 - 120.
MLA	saydam faruk,Değirmenci İrfan,GÜNEŞ HASAN VEYSİ MikroRNA’lar ve kanser. , 2011, ss.113 - 120.
AMA	saydam f,Değirmenci İ,GÜNEŞ H MikroRNA’lar ve kanser. . 2011; 113 - 120.
Vancouver	saydam f,Değirmenci İ,GÜNEŞ H MikroRNA’lar ve kanser. . 2011; 113 - 120.
IEEE	saydam f,Değirmenci İ,GÜNEŞ H "MikroRNA’lar ve kanser." , ss.113 - 120, 2011.
ISNAD	saydam, faruk vd. "MikroRNA’lar ve kanser". (2011), 113-120.

APA	saydam f, Değirmenci İ, GÜNEŞ H (2011). MikroRNA’lar ve kanser. Dicle Tıp Dergisi, 38(1), 113 - 120.
Chicago	saydam faruk,Değirmenci İrfan,GÜNEŞ HASAN VEYSİ MikroRNA’lar ve kanser. Dicle Tıp Dergisi 38, no.1 (2011): 113 - 120.
MLA	saydam faruk,Değirmenci İrfan,GÜNEŞ HASAN VEYSİ MikroRNA’lar ve kanser. Dicle Tıp Dergisi, vol.38, no.1, 2011, ss.113 - 120.
AMA	saydam f,Değirmenci İ,GÜNEŞ H MikroRNA’lar ve kanser. Dicle Tıp Dergisi. 2011; 38(1): 113 - 120.
Vancouver	saydam f,Değirmenci İ,GÜNEŞ H MikroRNA’lar ve kanser. Dicle Tıp Dergisi. 2011; 38(1): 113 - 120.
IEEE	saydam f,Değirmenci İ,GÜNEŞ H "MikroRNA’lar ve kanser." Dicle Tıp Dergisi, 38, ss.113 - 120, 2011.
ISNAD	saydam, faruk vd. "MikroRNA’lar ve kanser". Dicle Tıp Dergisi 38/1 (2011), 113-120.