TY  - JOUR
TI  - Evaluation of the Effects of Ribavirin and Proanthocyanidin on the Clinical Outcome, Hematological and Biochemical Parameters, and Viral Shedding in Canine Distemper
AB  - This study investigated the effects of ribavirin, proanthocyanidin, and ribavirin- proanthocyanidin in dogs naturally infected with canine distemper virus (CDV). Five groups were created, each with six dogs aged 2-6 months: one healthy control group and four patient groups. For ten days, the A group received classical treatment (CT) [fluid treatment and antibiotic], the A+R group received CT + ribavirin, the A+P group received CT + proanthocyanidin, A+R+P group received CT + ribavirin-proanthocyanidin. On days T0, T3, T7, and T10, hematological, biochemical, and clinical scores were done. These days and the fifth and tenth post-treatment days were also screened for CDV. Clinical improvement was best in the A+P, A+R, A, and A+R+P groups, respectively. The A+R group had fewer leucocytes, neutrophils, and monocytes (P<0.05). CK and CK-MB activity were significantly higher only in the A group (P<0.01), and decreased only in the A+R group as therapy progressed. Creatinine values were high in A+P and A+R groups (P<0.01). The lowest calcium value was in the A+R group (P<0.01). The least CDV presence was detected in the A+R group regarding viral shedding. As a result, using ribavirin or proanthocyanidin helped to lessen the severity of clinical findings, increase survival, and reduce viral shedding in dogs with CDV.
AU  - Değirmençay, Şükrü
DO  - 10.46810/tdfd.1244940
PY  - 2023
JO  - Türk Doğa ve Fen Dergisi
VL  - 12
IS  - 1
SN  - 2149-6366
SP  - 125
EP  - 135
DB  - TRDizin
UR  - http://search/yayin/detay/1167967
ER  -