Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years
Yıl: 2022 Cilt: 11 Sayı: 4 Sayfa Aralığı: 1625 - 1629 Metin Dili: İngilizce DOI: 10.5455/medscience.2022.08.197 İndeks Tarihi: 08-05-2023
Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years
Öz: Cervical cancer is the fourth most common cancer worldwide. Furthermore, it is the 9thmost common cancer in all ages and the 4thmost common in the 25-49 age group of women in Turkey. Given these significantly high figures, it is a significant public health problem. Therefore, this study aimed to evaluate the epidemiological characteristics of patients screened for Human papillomavirus (HPV) in a tertiary-care setting in Turkey. This is a retrospective chart review of patients admitted for clinical examinations and who underwent cervical cancer screening between 1 January 2017 and 1 March 2022. The data analyses included HPV positivity, genotype distribution, cytology analyses, colposcopy results, pathological diagnoses, and follow-up methods. A total of 529 cases were included, of whom 41.6% were HPV positive. The most frequent HPV types were HPV-16 (16.6%) and HPV-high risk (HR) (12.1%). Cytology analyses revealed atypical squamous cells of undetermined significance (ASC-US) in 17.8% and low-grade squamous intraepithelial lesions (LSIL) in 12.7%. The most common pathological finding was cervicitis in 23.1% (n=122), cervical intraepithelial neoplasia (CIN)-1 in 9.3% (n=49), CIN-3 in 4% (n=21), and CIN-2 in 3.8% (n=20) of patients. HPV-59 (p=0.027) and HPV-HR (p=0.003) genotypes were determined in higher proportions in patients with ≥ASC-US cytology, and HPV-16 was significantly higher among patients with ≥CIN-1 lesions. The HPV positivity rate was 41.6% among women admitted to our tertiary-care university hospital for gynecological assessments. Distribution differences in HPV genotypes, cytology assessments, and pathological diagnoses might reflect the population characteristics in different geographical regions from previous studies. Our results provide current data for HPV surveillance in the Turkish population.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. The Global Cancer Observatory (GLOBOCAN) of the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO). Cancer Today -GLOBOCAN. 2022 https://gco.iarc.fr/today/online analysispie ?v=2020&mode=cancer&mode_population=continents& population=900&populations=900&key=total&sex=2&cancer=39&type= 1&statistic=5&prevalence=0&population_group=0&ages_group % 5 B % 5 D = 0 & a g e s _ g r o u p % 5 B % 5 D = 1 7 & n b _ i t e m s = 7 & g r o u p _ c a n c e r = 1 & i n c l u d e _ n m s c = 1 & i n c l u d e _ n m s c _ o t h e r = 1 & h a l f _ pie=0&donut=0 access date 05.06.2022
- 2. Ministry of Health of Turkey. National Cancer Statistics Report. https:// hsgm.saglik.gov.tr/depo/birimler/kanser-db/istatistik/Turkiye_Kanser_ Istatistikleri_2017.pdf access date 05.06.2022
- 3. Okunade KS. Human papillomavirus and cervical cancer. J Obstet Gynaecol. 2020;40:602-8.
- 4. Gultekin M, Zayifoglu Karaca M, Kucukyildiz I, et al. Initial results of population based cervical cancer screening program using HPV testing in one million Turkish women. Int J Cancer. 2018;142:1952-58.
- 5. Ministry of Health of Turkey. Cancer Screening. https://hsgm.saglik.gov.tr/ tr/kanser-taramalari. access date 05.06.2022
- 6. World Health Organization (WHO). Meeting of WHO Director-General’s Expert Group on Cervical Cancer Elimination, 19 April 2022. https:// www.who.int/news/item/12-04-2022-meeting-of-who-director-general-s- expert-group-on-cervical-cancer-elimination--19-april-2022. access date 05.06.2022.
- 7. Huh WK, Ault KA, Chelmow D, et al. Use of primary high-risk human papillomavirus testing for cervical cancer screening: interim clinical guidance. Gynecol Oncol. 2015;136:178-82.
- 8. Dursun P, Ayhan A, Mutlu L, et al. HPV types in Turkey: multicenter hospital based evaluation of 6388 patients in Turkish gynecologic oncology group centers. Turk Patoloji Derg. 2013;29:210-6.
- 9. Kaleli İ, Aksoy L, Demir M, et al. Jinekoloji polikliniğine başvuran hastalarda insan papillomavirüs prevalansı ve genotip dağılımı [Prevalence and genotype distribution of human papillomavirus in patients attending to gynecology polyclinics]. Mikrobiyol Bul. 2019;53:170-8.
- 10. Alacam S, Bakir A. Human Papillomavirus Prevalence and Genotype Distribution in Cervical Swab Samples in Istanbul, Turkey. J Infect Dev Ctries. 2021;15(8):1190-1196. Published 2021 Aug 31.
- 11. Akyar I , Aydın Ö, Yakıcıer MC, et al. Human papillomavirus prevalence and type in liquid-based cervical samples from Turkish women in a selected risk group. Turkish Journal of Medical Sciences. 2013;43:963-70.
- 12. Yuce K, Pinar A, Salman MC, et al. Detection and genotyping of cervical HPV with simultaneous cervical cytology in Turkish women: a hospital- based study. Arch Gynecol Obstet. 2012;286:203-8.
- 13. Altay-Kocak A, Kazanci F, Dogu-Tok C, et al. The prevalence and distribution of human papillomavirus in 4267 Turkish women with or without cervical lesions: A hospital-based study. J Med Virol. 2022;94:5026-32.
APA | ÖNAL M, katırcı y, Kocaman A, Yıldız Ç (2022). Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years. , 1625 - 1629. 10.5455/medscience.2022.08.197 |
Chicago | ÖNAL MESUT,katırcı yunus,Kocaman Adem,Yıldız Çağlanur Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years. (2022): 1625 - 1629. 10.5455/medscience.2022.08.197 |
MLA | ÖNAL MESUT,katırcı yunus,Kocaman Adem,Yıldız Çağlanur Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years. , 2022, ss.1625 - 1629. 10.5455/medscience.2022.08.197 |
AMA | ÖNAL M,katırcı y,Kocaman A,Yıldız Ç Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years. . 2022; 1625 - 1629. 10.5455/medscience.2022.08.197 |
Vancouver | ÖNAL M,katırcı y,Kocaman A,Yıldız Ç Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years. . 2022; 1625 - 1629. 10.5455/medscience.2022.08.197 |
IEEE | ÖNAL M,katırcı y,Kocaman A,Yıldız Ç "Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years." , ss.1625 - 1629, 2022. 10.5455/medscience.2022.08.197 |
ISNAD | ÖNAL, MESUT vd. "Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years". (2022), 1625-1629. https://doi.org/10.5455/medscience.2022.08.197 |
APA | ÖNAL M, katırcı y, Kocaman A, Yıldız Ç (2022). Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years. Medicine Science, 11(4), 1625 - 1629. 10.5455/medscience.2022.08.197 |
Chicago | ÖNAL MESUT,katırcı yunus,Kocaman Adem,Yıldız Çağlanur Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years. Medicine Science 11, no.4 (2022): 1625 - 1629. 10.5455/medscience.2022.08.197 |
MLA | ÖNAL MESUT,katırcı yunus,Kocaman Adem,Yıldız Çağlanur Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years. Medicine Science, vol.11, no.4, 2022, ss.1625 - 1629. 10.5455/medscience.2022.08.197 |
AMA | ÖNAL M,katırcı y,Kocaman A,Yıldız Ç Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years. Medicine Science. 2022; 11(4): 1625 - 1629. 10.5455/medscience.2022.08.197 |
Vancouver | ÖNAL M,katırcı y,Kocaman A,Yıldız Ç Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years. Medicine Science. 2022; 11(4): 1625 - 1629. 10.5455/medscience.2022.08.197 |
IEEE | ÖNAL M,katırcı y,Kocaman A,Yıldız Ç "Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years." Medicine Science, 11, ss.1625 - 1629, 2022. 10.5455/medscience.2022.08.197 |
ISNAD | ÖNAL, MESUT vd. "Evaluation of cervical smear screening and colposcopy assessments at a tertiary obstetrics and gynecology center in the blacksea region of Turkey: Retrospective chart-review of the last 5 years". Medicine Science 11/4 (2022), 1625-1629. https://doi.org/10.5455/medscience.2022.08.197 |