Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury

KABAY, SAHIN; gören, hilal; Burukoglu Donmez, Dilek; OZ, SEMIH; ÜSTÜNER, MEHMET CENGIZ; HIZ, İhsan; Özden, Hilmi

doi:10.4274/jus.galenos.2022.2022.0011

Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury

Hilal Gören, (Bilecik Şeyh Edebali University Faculty of Medicine, Department of Anatomy, Bilecik, Turkiye)

SEMIH OZ, (Eskişehir Osmangazi University Faculty of Medicine, Vocational School of Health Services, Eskişehir, Turkiye)

Dilek Burukoğlu Dönmez, (Eskişehir Osmangazi University Faculty of Medicine, Department of Histology and Embriyology, Eskişehir, Turkiye)

M. Cengiz Üstüner, (Eskişehir Osmangazi University Faculty of Medicine, Department of Medical Biology, Eskişehir, Turkiye)

İhsan Hız, (Süleyman Demirel University Faculty of Medicine, Department of Anatomy, Isparta, Turkiye)

Hilmi Özden, (Eskişehir Osmangazi University Faculty of Medicine, Department of Anatomy, Eskişehir, Turkiye)

Şahin Kabay (Altınbaş University Faculty of Medicine, İstanbul, Turkiye)

Journal of Urological Surgery

9 2

Yıl: 2023 Cilt: 10 Sayı: 1 Sayfa Aralığı: 55 - 61 Metin Dili: İngilizce DOI: 10.4274/jus.galenos.2022.2022.0011 İndeks Tarihi: 08-05-2023

Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury

Öz:

Objective: Testicular torsion is one of the most common genital diseases in males in adolescence and it should be treated as soon as possible without ipsilateral testicular dysfunction. We investigated the protective effect of Capsaicin, which is an active ingredient of red-hot pepper, an antioxidant substance, on tissue damage caused by ischemia/reperfusion (I/R). Materials and Methods: Forty male, 250-300 g adult male rats were divided into 4 groups, 10 in each group. The torsion was created by rotating the spermatic cord of both testicles counterclockwise by 720°. In the experimental group where we applied capsaicin, detorsion was performed after 2 h of torsion. Malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were evaluated. Testicular tissue was stained with hematoxylin/eosin for histopathological evaluation. Results: In the Capsaicin group showed reduced tubular damage and seminiferous tubules in a structure similar to ischemia and spermatogenic cell series in the tubular wall and decreased edema in the interstitial area. SOD, MDA and CAT levels evaluated for the determination of lipid peroxidation were observed to be close to the control group values in the Capsaicin administered group. Conclusion: Capsaicin had a protective effect on I/R injury in the testicle.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	gören h, OZ S, Burukoglu Donmez D, ÜSTÜNER M, HIZ İ, Özden H, KABAY S (2023). Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury. , 55 - 61. 10.4274/jus.galenos.2022.2022.0011
Chicago	gören hilal,OZ SEMIH,Burukoglu Donmez Dilek,ÜSTÜNER MEHMET CENGIZ,HIZ İhsan,Özden Hilmi,KABAY SAHIN Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury. (2023): 55 - 61. 10.4274/jus.galenos.2022.2022.0011
MLA	gören hilal,OZ SEMIH,Burukoglu Donmez Dilek,ÜSTÜNER MEHMET CENGIZ,HIZ İhsan,Özden Hilmi,KABAY SAHIN Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury. , 2023, ss.55 - 61. 10.4274/jus.galenos.2022.2022.0011
AMA	gören h,OZ S,Burukoglu Donmez D,ÜSTÜNER M,HIZ İ,Özden H,KABAY S Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury. . 2023; 55 - 61. 10.4274/jus.galenos.2022.2022.0011
Vancouver	gören h,OZ S,Burukoglu Donmez D,ÜSTÜNER M,HIZ İ,Özden H,KABAY S Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury. . 2023; 55 - 61. 10.4274/jus.galenos.2022.2022.0011
IEEE	gören h,OZ S,Burukoglu Donmez D,ÜSTÜNER M,HIZ İ,Özden H,KABAY S "Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury." , ss.55 - 61, 2023. 10.4274/jus.galenos.2022.2022.0011
ISNAD	gören, hilal vd. "Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury". (2023), 55-61. https://doi.org/10.4274/jus.galenos.2022.2022.0011

APA	gören h, OZ S, Burukoglu Donmez D, ÜSTÜNER M, HIZ İ, Özden H, KABAY S (2023). Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury. Journal of Urological Surgery, 10(1), 55 - 61. 10.4274/jus.galenos.2022.2022.0011
Chicago	gören hilal,OZ SEMIH,Burukoglu Donmez Dilek,ÜSTÜNER MEHMET CENGIZ,HIZ İhsan,Özden Hilmi,KABAY SAHIN Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury. Journal of Urological Surgery 10, no.1 (2023): 55 - 61. 10.4274/jus.galenos.2022.2022.0011
MLA	gören hilal,OZ SEMIH,Burukoglu Donmez Dilek,ÜSTÜNER MEHMET CENGIZ,HIZ İhsan,Özden Hilmi,KABAY SAHIN Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury. Journal of Urological Surgery, vol.10, no.1, 2023, ss.55 - 61. 10.4274/jus.galenos.2022.2022.0011
AMA	gören h,OZ S,Burukoglu Donmez D,ÜSTÜNER M,HIZ İ,Özden H,KABAY S Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury. Journal of Urological Surgery. 2023; 10(1): 55 - 61. 10.4274/jus.galenos.2022.2022.0011
Vancouver	gören h,OZ S,Burukoglu Donmez D,ÜSTÜNER M,HIZ İ,Özden H,KABAY S Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury. Journal of Urological Surgery. 2023; 10(1): 55 - 61. 10.4274/jus.galenos.2022.2022.0011
IEEE	gören h,OZ S,Burukoglu Donmez D,ÜSTÜNER M,HIZ İ,Özden H,KABAY S "Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury." Journal of Urological Surgery, 10, ss.55 - 61, 2023. 10.4274/jus.galenos.2022.2022.0011
ISNAD	gören, hilal vd. "Protective Effects of Capsaicin on Experimental Testicular Torsion and Detorsion Injury". Journal of Urological Surgery 10/1 (2023), 55-61. https://doi.org/10.4274/jus.galenos.2022.2022.0011