TY  - JOUR
TI  - Resting-State Functional Connectivity Alterations in Drug- Naive Adolescents with Obsessive-Compulsive Disorder
AB  - Objective: It is known that there are alterations in functional brain networks in pediatric obsessive- compulsive disorder (OCD) and new studies are needed to identify and conceptualize these alterations. This study aimed to investigate resting-state functional connectivity (Rs-FC) changes in adolescents with OCD. Materials and Methods: We compared FC alterations in 15 drug-naive adolescents with OCD and 15 healthy controls (HC). Rs-FC networks were obtained with independent component analysis and logistic regression was used to identify the components that displayed significant group differentiation. Results: Data were decomposed into 30 independent components, and 4 components corresponding to functional networks showed a significant difference between the 2 groups (sensitivity and specificity value was 86.7%): Posterior cingulate cortex (PCC), cerebellum, right frontoparietal network (R-FPN), and anterior DMN (aDMN). The expression scores of the PCC, cerebellum, and R-FPN were significantly lower in OCD, while the expression score of the aDMN was significantly higher in OCD as compared with HC. In addition, OCD patients demonstrated a significant anti-correlation between the R-FPN and lateral sensorimotor network, and a positive correlation between the PCC and parahippocampal gyri. Conclusion: These findings indicate that alterations in FC networks incumbent on high mental processes are involved in the pathophysiology of OCD in adolescents.
AU  - Kurt, Elif
AU  - ERYÜREK, Kardelen
AU  - Demiralp, Tamer
AU  - Coskun, Murat
AU  - Kinay Ermis, Duygu
AU  - Ulasoglu-Yildiz, Cigdem
DO  - 10.5152/pcp.2021.20169
PY  - 2021
JO  - Psychiatry and clinical psychopharmacology (Online)
VL  - 31
IS  - 1
SN  - 2475-0581
SP  - 40
EP  - 47
DB  - TRDizin
UR  - http://search/yayin/detay/1168839
ER  -