Objectives: Theconsumptionofpopulartobaccoproducts has adverse effects on public health. Early diagnosis and treatment practices are essential based on the disease- symptom relationship in public health problems. There is a need to evaluate biochemical parameters to elucidate the pathophysiological mechanisms of these problems with experimental studies. We aimed to investigate the biochemical and physiological effects of cigarettes, hoo- kahs, and electronic cigarettes (e-cigarettes) that people commonly use. Methods: We have used Wistar albino rats, and the rats were exposed to cigarette smoke, e-cigarette smoke, and hookah smoke for 60 min/day for seven days. We detected malondialdehyde (MDA), nitric oxide (NOx), protein carbonyl oxidation (PCO), 8-hydroxy-2′-deoxyguanosine (8-OHdG), total antioxidant status (TAS), total oxidant status (TOS), reduced glutathione (GSH), and superoxide dismutase (SOD) levels in blood samples taken after the experiment. Results: We observed that the redox balance was disturbed in all groups. E-cigarettes mainly triggered lipid peroxidation; only hookah activated the intracellular antioxidant system. Conclusions: Cigarette, hookah, and e-cigarette smoking should be considered high-risk factors for individual and public health. The use of tobacco products adversely af- fects public health.