Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics
Yıl: 2022 Cilt: 47 Sayı: 3 Sayfa Aralığı: 119 - 129 Metin Dili: İngilizce DOI: 10.1515/tjb-2021-0277 İndeks Tarihi: 10-05-2023
Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics
Öz: Objectives: Neuroinflammation is an important factor in the pathogenesis of neurodegenerative disesases. The following study aimed to clarify the effects of β-lactam antibiotics to the cholinergic system, on acetylcholines- terase (AChE), butyrylcholinesterase (BuChE) activities, considering the structural differences of antibiotics, to evaluate the underlying mechanism of effects provided by protein-antibiotic interactions, and to clarify possible ef- fects of the antibiotics on the aggregation of Aβ-peptides. Methods: The inhibition/activation mechanisms for each antibiotic were examined kinetically by Ellman method. Destabilization effects of them on amyloid peptide fibrillation were examined and protein-ligand interactions were evaluated with most potent antibiotics by molecular docking studies. Results: Themostpowerfulinhibitionsweredetectedbythe inhibition studies of AChE with ceftazidime (CAZ) and BuChE with amoxicillin (AMX). CAZ was exhibited dose-related dual effect on AChE activity. CAZ was actually the dose-related modifier of AChE. At higher concentrations, CAZ was a nonessential activator of AChE. Molecular docking studies have been confirmed by kinetic studies. Interested β-lactam antibiotics did not prevent fibrillation rate as rifampicin. Conclusions: Inhibition/activation behaviours of studied β-lactam antibiotics on both cholinesterases may suggest that cholinergic transmission is one of the crucially important components of the β-lactam antibiotics-induced central nervous system adverse reactions.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | özturan özer e, Mirza H, Unsal Tan O, Türkoğlu S (2022). Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics. , 119 - 129. 10.1515/tjb-2021-0277 |
| Chicago | özturan özer eda,Mirza Hasan Cenk,Unsal Tan Oya,Türkoğlu Suna Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics. (2022): 119 - 129. 10.1515/tjb-2021-0277 |
| MLA | özturan özer eda,Mirza Hasan Cenk,Unsal Tan Oya,Türkoğlu Suna Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics. , 2022, ss.119 - 129. 10.1515/tjb-2021-0277 |
| AMA | özturan özer e,Mirza H,Unsal Tan O,Türkoğlu S Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics. . 2022; 119 - 129. 10.1515/tjb-2021-0277 |
| Vancouver | özturan özer e,Mirza H,Unsal Tan O,Türkoğlu S Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics. . 2022; 119 - 129. 10.1515/tjb-2021-0277 |
| IEEE | özturan özer e,Mirza H,Unsal Tan O,Türkoğlu S "Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics." , ss.119 - 129, 2022. 10.1515/tjb-2021-0277 |
| ISNAD | özturan özer, eda vd. "Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics". (2022), 119-129. https://doi.org/10.1515/tjb-2021-0277 |
| APA | özturan özer e, Mirza H, Unsal Tan O, Türkoğlu S (2022). Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics. Türk Biyokimya Dergisi, 47(3), 119 - 129. 10.1515/tjb-2021-0277 |
| Chicago | özturan özer eda,Mirza Hasan Cenk,Unsal Tan Oya,Türkoğlu Suna Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics. Türk Biyokimya Dergisi 47, no.3 (2022): 119 - 129. 10.1515/tjb-2021-0277 |
| MLA | özturan özer eda,Mirza Hasan Cenk,Unsal Tan Oya,Türkoğlu Suna Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics. Türk Biyokimya Dergisi, vol.47, no.3, 2022, ss.119 - 129. 10.1515/tjb-2021-0277 |
| AMA | özturan özer e,Mirza H,Unsal Tan O,Türkoğlu S Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics. Türk Biyokimya Dergisi. 2022; 47(3): 119 - 129. 10.1515/tjb-2021-0277 |
| Vancouver | özturan özer e,Mirza H,Unsal Tan O,Türkoğlu S Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics. Türk Biyokimya Dergisi. 2022; 47(3): 119 - 129. 10.1515/tjb-2021-0277 |
| IEEE | özturan özer e,Mirza H,Unsal Tan O,Türkoğlu S "Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics." Türk Biyokimya Dergisi, 47, ss.119 - 129, 2022. 10.1515/tjb-2021-0277 |
| ISNAD | özturan özer, eda vd. "Investigation of anti-cholinesterase and anti-amyloidogenic activities of β-lactam antibiotics". Türk Biyokimya Dergisi 47/3 (2022), 119-129. https://doi.org/10.1515/tjb-2021-0277 |
