TY  - JOUR
TI  - Real-World Evaluation of Anticoagulant Treatment Patterns in Patients with Atrial Fibrillation: Data from Multicenter ROTA Study
AB  - Objective: Oral anticoagulant therapy is the cornerstone of atrial fibrillation management to prevent stroke and systemic embolism. However, there is limited real-world information regarding stroke and systemic embolism prevention strategies in patients with atrial fibrillation. The aim of the ROTA study is to obtain the real-world data of anticoagulant treatment patterns in patients with atrial fibrillation. Materials and Methods: The ROTA study is a prospective, multicenter, and observational study that included 2597 patients with atrial fibrillation. The study population was recruited from 41 cardiology outpatient clinics between January 2021 and May 2021. Results: The median age of the study population was 72 years (range: 22-98 years) and 57.4% were female. The median CHA2DS2-VASc and HAS-BLED scores were 4 (range: 0-9) and 1 (range: 0-6), respectively. Vitamin K antagonists and direct oral anticoagulants were used in 15.9% and 79.4% of patients, respectively. The mean time in therapeutic range was 52.9% for patients receiving vitamin K antagonists, and 76% of those patients had an inadequate time in therapeutic range with <70%. The most common prescribed direct oral anticoagulants were rivaroxaban (38.1%), apixaban (25.5%), and edoxaban (11.2%). The rate of overuse of vitamin K antagonists and direct oral anticoagulants was high (76.1%) in patients with low stroke risk, and more than one-fourth of patients on direct oral anticoagulant therapy were receiving a reduced dose of direct oral anticoagulants. Among patients who were on direct oral anticoagulant treatment, patients with apixaban treatment were older, had higher CHA2DS2- VASc and HAS-BLED scores, and had lower creatinine clearance than the patients receiving other direct oral anticoagulants. Conclusions: The ROTA study provides important real-world information about anticoagulant treatment patterns in patients with atrial fibrillation.
AU  - ÇAYIRLI, SERCAN
AU  - Yavuz, Veysel
AU  - Erdoğan, Aslan
AU  - Çoner, Ali
AU  - Kocabas, Umut
AU  - ŞAHİN, ŞEYDA
AU  - naki, deniz dilan
AU  - özdemir, ibrahim halil
AU  - DOGDUS, Mustafa
AU  - DEMIR, MEVLUT
AU  - genç, ömer
AU  - ALTIN, Cihan
AU  - Tüner, Haşim
AU  - keskin, bengisu
AU  - Ergin, Isil
AU  - MURAT, Selda
AU  - Yüce, Elif ilkay
AU  - Boyraz, Bedrettin
AU  - Aslan, Onur
AU  - sen, taner
AU  - Ibisoglu, Ersin
AU  - Özgeyik, Mehmet
AU  - Bilgel, Ziya Gökalp
AU  - Güvendi Şengör, Büşra
AU  - Urgun, Örsan Deniz
AU  - Çakal, Sinem
AU  - Güler, Arda
AU  - karabulut, dilay
AU  - Dalgıç, Onur
AU  - Uzman, Osman
AU  - Murat, Bektas
AU  - Karabulut, Umut
AU  - KIVRAK, tarik
AU  - COŞGUN, MUHARREM SAİD
AU  - ozyurtlu, ferhat
AU  - KAPLAN, MEHMET
AU  - Ozcalik, Emre
AU  - DAL, Ahmet
DO  - 10.5543/tkda.2022.98455
PY  - 2023
JO  - Türk Kardiyoloji Derneği Arşivi
VL  - 51
IS  - 2
SN  - 1016-5169
SP  - 88
EP  - 96
DB  - TRDizin
UR  - http://search/yayin/detay/1169237
ER  -