Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism

YILMAZ, Onur; Sivrikaya, Efe Can; Korkmaz, Yavuz Tolga; Şahin, Elif; Tüzüner, Tamer; KOÇAK, NEJDET; Alver, Ahmet

doi:10.5455/annalsmedres.2022.07.205

Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism

Onur YILMAZ, (Karadeniz Teknik Üniversitesi Diş Hekimliği Fakültesi Ağız ve Diş Çene Cerrahisi Anabilim Dalı, Trabzon, Türkiye)

Efe Can SİVRİKAYA, (Karadeniz Teknik Üniversitesi Diş Hekimliği Fakültesi Ağız ve Diş Çene Cerrahisi Anabilim Dalı, Trabzon, Türkiye)

NEJDET KOÇAK, (Karadeniz Teknik Üniversitesi Diş Hekimliği Fakültesi Ağız ve Diş Çene Cerrahisi Anabilim Dalı, Trabzon, Türkiye)

ELİF ŞAHİN, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Trabzon, Türkiye)

Tamer TÜZÜNER, (Karadeniz Teknik Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Anabilim Dalı, Trabzon, Türkiye)

Ahmet ALVER, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Trabzon, Türkiye)

Yavuz Tolga KORKMAZ (Karadeniz Teknik Üniversitesi Diş Hekimliği Fakültesi Ağız ve Diş Çene Cerrahisi Anabilim Dalı, Trabzon, Türkiye)

Annals of Medical Research

2 0

Yıl: 2022 Cilt: 29 Sayı: 10 Sayfa Aralığı: 1146 - 1150 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2022.07.205 İndeks Tarihi: 10-05-2023

Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism

Öz:

Aim: The purpose of this study was to evaluate brain-derived neurotrophic factor (BDNF) and cortisol levels in patients with bruxism. Relationships between clinical variables (my- ofacial pain, dental anxiety and masticatory function) and BDNF and cortisol levels were also investigated. Materials and Methods: In this prospective study, patients were divided into 4 groups according to the severity of bruxism; group I (no bruxism, control group), group II (mild bruxism), group III (moderate bruxism), group IV (severe bruxism). Cortisol and BDNF levels were evaluated from venous blood samples of patients. Myofacial pain was evaluated with the Visual Analogue Scale (VAS), dental anxiety was evaluated with the Modified Dental Anxiety Scale (MDAS), and masticatory function limitation was evaluated with the Jaw Functional Limitation Scale (JFLS). Results: The study conducted with 75 patients (15 in group I, 20 in group II, 20 in group III, and 20 in group IV) aged 18-64 years. BDNF and cortisol levels increased as the severity of bruxism increased. The cortisol level of group III was significantly higher than that of group I (p=0.008). BDNF and cortisol levels in group IV were significantly higher than group I (p=0.043, p=0.006). VAS, JFLS and MDAS values increased as the severity of bruxism increased. VAS pain scores correlated significantly with BDNF and cortisol levels (r=0.220, p=0.038; r=0.286, p=0.013). MDAS and JFLS values were significantly correlated with cortisol levels (r=0.279, p=0.015; r=0.271, p=0.19). Conclusion: Plasma BDNF and cortisol levels can contribute to the assessment of brux- ism severity and its clinical findings such as myofacial pain, masticatory efficiency and dental anxiety.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YILMAZ O, Sivrikaya E, KOÇAK N, Şahin E, Tüzüner T, Alver A, Korkmaz Y (2022). Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism. , 1146 - 1150. 10.5455/annalsmedres.2022.07.205
Chicago	YILMAZ Onur,Sivrikaya Efe Can,KOÇAK NEJDET,Şahin Elif,Tüzüner Tamer,Alver Ahmet,Korkmaz Yavuz Tolga Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism. (2022): 1146 - 1150. 10.5455/annalsmedres.2022.07.205
MLA	YILMAZ Onur,Sivrikaya Efe Can,KOÇAK NEJDET,Şahin Elif,Tüzüner Tamer,Alver Ahmet,Korkmaz Yavuz Tolga Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism. , 2022, ss.1146 - 1150. 10.5455/annalsmedres.2022.07.205
AMA	YILMAZ O,Sivrikaya E,KOÇAK N,Şahin E,Tüzüner T,Alver A,Korkmaz Y Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism. . 2022; 1146 - 1150. 10.5455/annalsmedres.2022.07.205
Vancouver	YILMAZ O,Sivrikaya E,KOÇAK N,Şahin E,Tüzüner T,Alver A,Korkmaz Y Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism. . 2022; 1146 - 1150. 10.5455/annalsmedres.2022.07.205
IEEE	YILMAZ O,Sivrikaya E,KOÇAK N,Şahin E,Tüzüner T,Alver A,Korkmaz Y "Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism." , ss.1146 - 1150, 2022. 10.5455/annalsmedres.2022.07.205
ISNAD	YILMAZ, Onur vd. "Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism". (2022), 1146-1150. https://doi.org/10.5455/annalsmedres.2022.07.205

APA	YILMAZ O, Sivrikaya E, KOÇAK N, Şahin E, Tüzüner T, Alver A, Korkmaz Y (2022). Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism. Annals of Medical Research, 29(10), 1146 - 1150. 10.5455/annalsmedres.2022.07.205
Chicago	YILMAZ Onur,Sivrikaya Efe Can,KOÇAK NEJDET,Şahin Elif,Tüzüner Tamer,Alver Ahmet,Korkmaz Yavuz Tolga Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism. Annals of Medical Research 29, no.10 (2022): 1146 - 1150. 10.5455/annalsmedres.2022.07.205
MLA	YILMAZ Onur,Sivrikaya Efe Can,KOÇAK NEJDET,Şahin Elif,Tüzüner Tamer,Alver Ahmet,Korkmaz Yavuz Tolga Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism. Annals of Medical Research, vol.29, no.10, 2022, ss.1146 - 1150. 10.5455/annalsmedres.2022.07.205
AMA	YILMAZ O,Sivrikaya E,KOÇAK N,Şahin E,Tüzüner T,Alver A,Korkmaz Y Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism. Annals of Medical Research. 2022; 29(10): 1146 - 1150. 10.5455/annalsmedres.2022.07.205
Vancouver	YILMAZ O,Sivrikaya E,KOÇAK N,Şahin E,Tüzüner T,Alver A,Korkmaz Y Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism. Annals of Medical Research. 2022; 29(10): 1146 - 1150. 10.5455/annalsmedres.2022.07.205
IEEE	YILMAZ O,Sivrikaya E,KOÇAK N,Şahin E,Tüzüner T,Alver A,Korkmaz Y "Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism." Annals of Medical Research, 29, ss.1146 - 1150, 2022. 10.5455/annalsmedres.2022.07.205
ISNAD	YILMAZ, Onur vd. "Evaluation of brain-derived neurotrophic factor and cortisol levels in patients with bruxism". Annals of Medical Research 29/10 (2022), 1146-1150. https://doi.org/10.5455/annalsmedres.2022.07.205