TY  - JOUR
TI  - Hepatocellular Carcinoma in Cirrhotic Versus Noncirrhotic Livers: Clinicomorphologic Findings and Prognostic Factors
AB  - carcinoma and non-cirrhotic hepatocellular carcinoma also differ. We aimed to determine the clinicopathologic features, tumor charac- teristics, treatment options, and overall survival after diagnosing hepatocellular carcinoma and prognostic factors effective on survival of hepatocellular carcinoma developing in cirrhotic and non-cirrhotic conditions. Methods: In our study, 220 patients aged over 18 years who were histologically diagnosed as having hepatocellular carcinoma were included. The patients were divided into 2 groups as cirrhotic and non-cirrhotic. Results: When the tumor morphologies were examined in our study, it was observed that they were mostly solitary in both groups. Cirrhotic hepatocellular carcinomas had significantly higher rates of invasion than the non-cirrhotic group (35.3% vs. 20.3%, respec- tively) (P < .05). The survival rate was found to be better in the non-cirrhotic group (17.5 months vs. 11.5 months) (P < .05). Age, maximal tumor diameter, and morphologically infiltrative tumor character were found to be independent risk factors affecting survival in patients with cirrhosis. Portal vein invasion, alfa-fetoprotein, and the absence of an underlying risk factor in the etiology were observed as inde- pendent risk factors affecting survival in patients with non-cirrhosis. Conclusion: Cirrhotic hepatocellular carcinoma and non-cirrhotic hepatocellular carcinoma had different clinicopathologic features and risk factors. We analyzed that treatment choice trends were different between the 2 groups. We also observed that the factors that affected survival were different between the 2 groups.
AU  - karaoğullarından, ümit
AU  - uskudar, oguz
AU  - Odabaş, Emre
AU  - Ak, Numan Emre
AU  - Kuran, Sedef
DO  - 10.5152/tjg.2023.21791
PY  - 2023
JO  - Turkish Journal of Gastroenterology
VL  - 34
IS  - 3
SN  - 1300-4948
SP  - 262
EP  - 269
DB  - TRDizin
UR  - http://search/yayin/detay/1169600
ER  -