Yıl: 2023 Cilt: 7 Sayı: 2 Sayfa Aralığı: 134 - 138 Metin Dili: Türkçe DOI: 10.37783/CRJ-0351 İndeks Tarihi: 11-05-2023

Trombofili ve Retina

Öz:
Retinal vasküler tıkanıklıklar görme kaybı yaratan en sık görülen retina hastalıklarındandır. Trombofili, genetik veya akkiz tromboz oluşturan faktörler sonucunda ortaya çıkan tromboz eğilimidir. Retina arter ve ven oklüzyonlarında bildirilen en sık trombofilik bozukluk Faktör V Leiden mutasyonu ve Antifosfolipid Antikor Sendromu olup, en az sıklıkla bildirilen trombofilik bozukluk Anti-trombin III, Protein S, Protein C eksiklikleridir. Bunlara ilaveten hiperhomosisteinemi ve Metilentetrahidrofolat redüktaz polimorfizmine de sık rastlanmaktadır. Herhangi bir sistemik hastalığı olmayan yaşlı hastalarda, genç hastalarda, bilateral retinal vasküler tıkanıklığının görüldüğü olgularda, önceki tromboemboli öyküsü tarifleyen olgularda veya ailede tromboz öyküsü varlığında trombofili ve koagulopati açısından detaylı araştırma yapılmalıdır.
Anahtar Kelime:

Thrombophilia and Retina

Öz:
Retinal vascular occlusions are one of the most common retinal diseases that cause vision loss. Thrombophilia is the tendency of the formation of thrombosis secondary to genetic or acquired factors. The most frequent thrombophilic disorders reported in retinal arterial and venous occlusions are Factor V Leiden mutation and Antiphospholipid Syndrome, whereas the least reported thrombophilic conditions are Anti-thrombin III, Protein S, and Protein C deficiencies. In addition, Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase polymorphism are frequently seen. When retinal vascular occlusions are seen in elderly patients without any systemic diseases, in young patients, in patients with previous thromboembolic events or family thrombosis history, thrombophilia screening tests should be performed in detail.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Bibliyografik
  • 1. Kolar P. Risk factors for central and branch retinal vein occlusion: a meta-analysis of published clinical data. J Ophthalmology 2014; 2014: 724780.
  • 2. Chak M, Wallace GR, Graham EM, Stanford MR. Thrombophilia: genetic polymorphisms and their association with retinal vascular occlusive disease. Br J Ophthalmol 2001; 85(7): 883-886.
  • 3. Jacobson DM, Vierkant RA, Belongia EA. Nonarteritic ishaemic neuropathy: A case control study of potential risk factors. Arch Ophthalmol 1997; 115(11): 1403-1407.
  • 4. Salomon O, Huna-Baron R, Kurtz S, Steinberg DM, Moisseiev J, Rosenberg N, et al. Analysis of prothrombotic and vascular risk factors in patients with nonarteritic anterior ischemic optic neuropathy. Ophthalmology 1999; 106(4): 739-742.
  • 5. Beyan C. Trombofilili hastada tanısal yaklaşım. Türk Hematoloji Derneği Temel Hemostaz Tromboz Kursu, sayfa 68-75.
  • 6. Marcinkowska A, Cisiecki S, Rozalski M. Platelet and thrombophilia- related risk factors of retinal vein occlusion. J Clin Med 2021;10(14):3080.
  • 7. Romiti GF, Corica B, Borgi M, Visioli G, Pacella E, Cangemi R, et al. Inherited and acquired thrombophilia in adults with retinal vascular occlusion: a systematic review and meta-analysis. J Thromb Haemost 2020; 18(12): 3249-3266.
  • 8. Doğan E, Altıparmak UE, Fen T, Üner G, Acar MA, Örnek F. Multipl kalıtsal trombofili ve tekrarlayan retinal ven tıkanıklığı. Retina Vitreus 2012; 20(4): 315-218.
  • 9. Dixon SG, Bruce CT, Glueck CJ, Sisk RA, Hutchins RK, Jetty V, et al. Retinal vascular occlusion: a window to diagnosis of familial and acquired thrombophilia and hypofibrinolysis, with important ramifications for pregnancy outcomes. Clinical Ophthalmology 2016; 10: 1479-1486.
  • 10. Fegan CD. Central retinal vein occlusion and thrombophilia. Eye 2002; 16(1): 98-106.
  • 11. Kirkegaard K, Heegaard S, Hvas AM. No evidence for thrombophilia in patient with retinal vein occlusion: a systematic GRADE-based review. Acta Ophthalmologica 2017; 95(1): 12-19.
  • 12. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369(6475): 64-67.
  • 13. Huisman MV, Rosendaal F. Thrombophilia. Curr Opin Haematol 1999; 6(5): 291-297.
  • 14. Rajagopal R, Apte RS. Seeing through thick and through thin: Retinal manifestations of thrombophilic and hyperviscosity syndromes. Survey of Ophthalmology 2016; 61(2): 236-247.
  • 15. Bertina RM, Rosendaal FR. Venous thrombosis-the interaction of genes and enviroment. N Engl J Med 1998; 338(25): 1840-1841.
  • 16. Martinelli I, Sacchi E, Landi G, Taioli E, Duca F, Mannucci PM. High risk of cerebral vein thrombosis in carriers of a prothrombin gene mutation and and in users of oral contraceptives. N Engl J Med 1998; 338(25): 1793-1797.
  • 17. Greiner K, Hafner G, Dick B, Peetz D, Prellwitz W, Pfeiffer N. Retinal vascular occlusions and deficiencies in the protein C pathway. Am J Ophthalmol 1999; 128(1): 69-74.
  • 18. Akay F, Altınışık M, Güven YZ. Santral retinal ven tıkanıklığı ile makula ödeminde genetik ve risk faktörleri. Güncel Retina 2019; 3(1): 5-8.
  • 19. Wenzler EM, Rademakers AJJM, Boers GHJ. Hyperhomocysteinemia in retinal artery and retinal vein occlusion. Am J Ophthalmol 1993; 115(2): 162-167.
  • 20. Moll S, Varga EA. Homocysteine and MTHFR mutations. Circulation 2015; 132(1): e6-e9.
  • 21. Karia N. Retinal vein occlusion: pathophysiology and treatment options. Clinical Ophthalmology 2010; 4: 809-816.
  • 22. Paccalin M, Manic H, Bouche G, Landron C, Mercie M, Boinot C, et al. Antiphospolipid syndrome in patients with retinal venous occlusion. Thromb Res 2006; 117(4): 365-369.
  • 23. Tourville E, Schachat AP. Vascular Occlusive Disease- Plasma proteins-possible risk factors for retinal vascular occlusive disease. Joussen AM, Gardner TW, Kirchhof B, Ryan SJ (ed) İçinde: Retinal Vascular Disease. Springer Berlin, Heidelberg. 2007; 424-442.
  • 24. Cassels-Brown A, Minford AMB, Chatfield SL, Bradbury JA. Ophthalmic manifestations of neonatal protein C deficiency. Br J Ophthalmol 1994; 78(6): 486-487.
  • 25. Yau JWY, Lee P, Wong TY, Best J, Jenkins A. Retinal vein occlusion: an approach to diagnosis, systemic risk factors and management. Intern Med Journal 2008; 38(12): 904-910.
APA DİNÇ U (2023). Trombofili ve Retina. , 134 - 138. 10.37783/CRJ-0351
Chicago DİNÇ Umut Aslı Trombofili ve Retina. (2023): 134 - 138. 10.37783/CRJ-0351
MLA DİNÇ Umut Aslı Trombofili ve Retina. , 2023, ss.134 - 138. 10.37783/CRJ-0351
AMA DİNÇ U Trombofili ve Retina. . 2023; 134 - 138. 10.37783/CRJ-0351
Vancouver DİNÇ U Trombofili ve Retina. . 2023; 134 - 138. 10.37783/CRJ-0351
IEEE DİNÇ U "Trombofili ve Retina." , ss.134 - 138, 2023. 10.37783/CRJ-0351
ISNAD DİNÇ, Umut Aslı. "Trombofili ve Retina". (2023), 134-138. https://doi.org/10.37783/CRJ-0351
APA DİNÇ U (2023). Trombofili ve Retina. Güncel Retina Dergisi, 7(2), 134 - 138. 10.37783/CRJ-0351
Chicago DİNÇ Umut Aslı Trombofili ve Retina. Güncel Retina Dergisi 7, no.2 (2023): 134 - 138. 10.37783/CRJ-0351
MLA DİNÇ Umut Aslı Trombofili ve Retina. Güncel Retina Dergisi, vol.7, no.2, 2023, ss.134 - 138. 10.37783/CRJ-0351
AMA DİNÇ U Trombofili ve Retina. Güncel Retina Dergisi. 2023; 7(2): 134 - 138. 10.37783/CRJ-0351
Vancouver DİNÇ U Trombofili ve Retina. Güncel Retina Dergisi. 2023; 7(2): 134 - 138. 10.37783/CRJ-0351
IEEE DİNÇ U "Trombofili ve Retina." Güncel Retina Dergisi, 7, ss.134 - 138, 2023. 10.37783/CRJ-0351
ISNAD DİNÇ, Umut Aslı. "Trombofili ve Retina". Güncel Retina Dergisi 7/2 (2023), 134-138. https://doi.org/10.37783/CRJ-0351